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Chemical Structure| 1204701-61-0 Chemical Structure| 1204701-61-0

Structure of 1204701-61-0

Chemical Structure| 1204701-61-0

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Product Details of [ 1204701-61-0 ]

CAS No. :1204701-61-0
Formula : C10H13ClN2
M.W : 196.68
SMILES Code : ClC1=NC=CC(CN2CCCC2)=C1

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Application In Synthesis of [ 1204701-61-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1204701-61-0 ]

[ 1204701-61-0 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 25475-67-6 ]
  • [ 1204701-61-0 ]
  • [ 1204701-69-8 ]
YieldReaction ConditionsOperation in experiment
With caesium carbonate;tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; In toluene; at 100℃; EXAMPLE 1;lsoquinolin-3-vH4-pyrrolidin-1-ylmethyl-pyridin-2-yl)-amine; 2-Chloro-4-pyrrolidin-1-ylmethyl-pyridine (1eq), isoquinoline-3-ylamine (1eq), 2.0 eq. of caesium carbonate, 10percent (mol) Xantphos and 10percent (mol) of Pd2(dba)3 were mixed in toluene (3 ml). The reaction mixture was degassed for three times and then warmed to 100°C overnight. The reaction mixture was cooled, concentrated and purified by column chromatography eluting 0 -10percent sat. NH3ZMeOH and DCM to afford the title compound.LCMS r.t. 2.93 305.3 (MH+, ES+)1H NMR (DMSO-d6): delta 11.17-10.94 (1 H, br s), 9.22 (1 H, s), 8.40 (1 H, d), 8.18-8.08 (2H, br m), 7.93 (1 H, br d), 7.75 (1 H, br t), 7.57-7.49 (2H, m), 7.35-7.29 (1 H, br m), 4.45 (2H, br d), 3.47-3.42 (2H, m), 3.15-3.03 (2H, m), 2.11-1.98 (2H, m), 1.97-1.85 (2H, m).
 

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