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Chemical Structure| 1204742-71-1 Chemical Structure| 1204742-71-1

Structure of 1204742-71-1

Chemical Structure| 1204742-71-1

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Product Details of [ 1204742-71-1 ]

CAS No. :1204742-71-1
Formula : C8H10BClN2O4S
M.W : 276.51
SMILES Code : ClC(N=C1)=C(NS(=O)(C2CC2)=O)C=C1B(O)O

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Application In Synthesis of [ 1204742-71-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1204742-71-1 ]

[ 1204742-71-1 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1112982-76-9 ]
  • [ 1204742-71-1 ]
  • [ 1204742-28-8 ]
YieldReaction ConditionsOperation in experiment
With potassium carbonate;tetrakis(triphenylphosphine) palladium(0); In 1,4-dioxane; water; at 120℃; for 0.333333h;Microwave irradiation; Example 49; Preparation of 7V-(5-(6-Chloro-5-(cyclopropanesulfonamido)pyridin-3- yl)thiazolo[5,4-Z>]pyridin-2-yl)acetamide (49); Example 49[0434] 2-Chloro-5-(4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2-yl)pyridin-3-amine (49A, 100 mg, 0.39 mmol), cyclopropanesulfonyl chloride (221 mg, 1.6 mmol) were mixed in 2 mL pyridine. The mixture was heated at 70 0C overnight. The crude was purified by preparative HPLC (0.05% TFA in mobile phase) to give 6-chloro-5- (cyclopropanesulfonamido)pyridin-3-ylboronic acid (49B, 87 mg), which was mixed with Example 1 (86 mg, 0.32 mmol), Pd(PPh3)4 (91.1 mg, 0.079 mmol), K2CO3 (sat., 1 mL) in 2 mL of 1,4-dioxane. The reaction mixture was heated in a microwave at 120 0C for 20 minutes. The reaction mixture was purified using preparative HPLC to give the titled compound as a yellowish solid (5 mg). 1H NMR (400 MHz, OMSO-Cl6) delta ppm 8.39 (d, J=8.0 Hz, IH), 8.35 (d, J=8.0 Hz, IH), 8.22 (d, J=8.0 Hz, IH), 8.04 (d, J=8.0 Hz, IH), 2.79 (m, IH) 2.25 (s, 3H), 1.02 (m, 2H), 0.94 (m, 2H); [M+H] calc'd for Ci6H14ClN5O3S2,424; found, 424.
 

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