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Chemical Structure| 1205125-46-7 Chemical Structure| 1205125-46-7

Structure of 1205125-46-7

Chemical Structure| 1205125-46-7

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Product Details of [ 1205125-46-7 ]

CAS No. :1205125-46-7
Formula : C12H16N4
M.W : 216.28
SMILES Code : C12=NC=CN1C=C(NC3CCCCC3)C=N2
MDL No. :MFCD24618877

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Application In Synthesis of [ 1205125-46-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1205125-46-7 ]

[ 1205125-46-7 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 865156-68-9 ]
  • [ 108-91-8 ]
  • [ 1205125-46-7 ]
YieldReaction ConditionsOperation in experiment
With potassium carbonate; In acetonitrile; at 120℃; for 0.5h;sealed tube; Microwave irradiation; EXAMPLE 25c N-cyclohexylimidazo[1,2-a]pyrimidin-6-amine The product can be prepared in the following way: 3.2 g of <strong>[865156-68-9]6-bromoimidazo[1,2-a]pyrimidine</strong>, 5.5 ml of cyclohexylamine and 32 ml of acetonitrile are charged to a glass tube. The tube is sealed and heated at 120 C. for 30 minutes using microwave radiation. After returning to a temperature in the vicinity of 20 C., 100 ml of an aqueous potassium carbonate solution are added and the resulting aqueous phase is extracted with 3 times 150 ml of ethyl acetate and 1 times 150 ml of dichloromethane. The organic phases are combined, washed with 2 times 200 ml of an aqueous sodium chloride solution, dried over sodium sulphate, filtered and concentrated by evaporation under reduced pressure. The residue obtained is chromatographed on silica gel (eluent dichloromethane/methanol 95/5). 720 mg of N-cyclohexylimidazo[1,2-a]pyrimidin-6-amine are thus obtained in the form of a brown oil. MS: method A; [M+H]+ m/z=217; Tr=0.45 min.
 

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