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Chemical Structure| 1206207-42-2 Chemical Structure| 1206207-42-2

Structure of 1206207-42-2

Chemical Structure| 1206207-42-2

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Product Details of [ 1206207-42-2 ]

CAS No. :1206207-42-2
Formula : C5H5N3S2
M.W : 171.24
SMILES Code : CSC1=NN2C(S1)=NC=C2

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Application In Synthesis of [ 1206207-42-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1206207-42-2 ]

[ 1206207-42-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 107-20-0 ]
  • [ 5319-77-7 ]
  • [ 1206207-42-2 ]
YieldReaction ConditionsOperation in experiment
2-Amino-5-methylthio-1 ,3,4-thiadiazole (10.00 g; 67.92 mmol; 1.00 eq.) was reluxed in 1- butanol (100.00 ml) until complete dissolution of starting material. Then, chloroacetaldehyde (21.91 ml; 169.81 mmol; 2.50 eq.) was slowly added and the reaction was refluxed for 2 h. Diisopropyethylamine (11.63 ml) was slowly added over 2h using a syringe pump. After 18h, the reaction was allowed to cool to room temperature. Then, water was added and the aqueous phase was extracted 4 times with EtOAc. The combined organics were washed with brine, dried over MgSO4 to give 17 g of a viscous brown oil. The crude was purified by flash chromatography (preabsorption using MeOH an silica) using 95/5 dichloromethane/methanol. The combined fractions gave 3.05 g of the desired product as a pale orange solid.
 

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