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Chemical Structure| 1207543-31-4 Chemical Structure| 1207543-31-4

Structure of 1207543-31-4

Chemical Structure| 1207543-31-4

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Product Details of [ 1207543-31-4 ]

CAS No. :1207543-31-4
Formula : C12H19IN4OSi
M.W : 390.30
SMILES Code : C[Si](C)(CCOCN1C=C(I)C2=C(N)N=CN=C21)C
MDL No. :MFCD29054535

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Application In Synthesis of [ 1207543-31-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1207543-31-4 ]

[ 1207543-31-4 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1207543-31-4 ]
  • [ 1308298-23-8 ]
  • 5-[2-(trifluoromethyl)pyrimidin-5-yl]-7-[2-(trimethylsilyl)ethoxy]methyl}-7H-pyrrolo[2,3-d]pyrimidin-4-amine [ No CAS ]
YieldReaction ConditionsOperation in experiment
84% With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate; In 1,4-dioxane; water; at 100℃; for 4.0h;Inert atmosphere; To a solution of 113 5-iodo-7-[2-(trimethylsilyl)ethoxy]methyl}-7H-pyrrolo[2,3-d]pyrimidin-4-amine (Preparation 33, 43 g, 110 mmol), 114 2-(trifluoromethyl)pyrimidin-5-yl boronic acid (36.2 g, 132 mmol) in 115 1,4-dioxane (220 mL) at rt was added 116 K2CO3 (30 g, 217 mmol) in 33 H2O (40 mL) and 117 PdCl2(dppf) (8.1 g, 11.1 mmol) under N2 and the reaction stirred at 100° C. for 4 hrs. The cooled reaction was filtered and the filtrate concentrated under reduced pressure. The crude product was purified by column chromatography on silica gel eluting with pet. ether:81 EtOAc (50:50) to afford the 91 title compound (38 g, 84percent) as a yellow solid. 1HNMR (400 MHz, DMSO-d6): 0.00 (s, 9H), 0.93 (t, 2H), 3.64 (t, 2H), 5.64 (s, 2H), 6.73 (br s, 2H), 7.88 (s, 1H), 8.31 (s, 1H), 9.13 (s, 2H). LCMS m/z=411.1[MH]+
 

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