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Chemical Structure| 1211514-97-4 Chemical Structure| 1211514-97-4

Structure of 1211514-97-4

Chemical Structure| 1211514-97-4

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Product Details of [ 1211514-97-4 ]

CAS No. :1211514-97-4
Formula : C7H4F3N3
M.W : 187.12
SMILES Code : N#CC1=C(N)N=CC(C(F)(F)F)=C1
MDL No. :MFCD18261102

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Application In Synthesis of [ 1211514-97-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1211514-97-4 ]

[ 1211514-97-4 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 557-21-1 ]
  • [ 79456-30-7 ]
  • [ 1211514-97-4 ]
YieldReaction ConditionsOperation in experiment
3.65 g With 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium(0); In N,N-dimethyl-formamide; at 120℃; for 0.5h; Production Example 17 (1) [0787] A mixture of 5.22 g of <strong>[79456-30-7]2-amino-3-bromo-5-trifluoromethylpyridine</strong>, 3.80 g of zinc cyanide, 600 mg of tris(dibenzylideneacetone)dipalladium(O), 720 g of 1,1'-bis (diphenylphosphino) ferrocene and 20 ml of DMF was stirred at 120C for 30 minutes. Ethyl acetate and water were added to the cooled reaction mixture, and the mixture was filtered. The aqueous layer of the filtrate was extracted with ethyl acetate, then combined with the organic layer of the filtrate and washed with water, and dried over anhydrous magnesium sulfate. The mixture was concentrated under reduced pressure, and then the resulting residue was applied to a silica gel column chromatography to obtain 3.65 g of 2-amino-3-cyano-5-trifluoromethylpyridinepyridine. 2-Amino-3-cyano-5-trifluoromethylpyridinepyridine 1H-NMR (CDCl3) delta: 8.50(1H, d), 7.93(1H, d), 5.60(2H, brs)
 

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