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Chemical Structure| 1212413-55-2 Chemical Structure| 1212413-55-2

Structure of 1212413-55-2

Chemical Structure| 1212413-55-2

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Product Details of [ 1212413-55-2 ]

CAS No. :1212413-55-2
Formula : C12H23NO4
M.W : 245.32
SMILES Code : O=C(N1C[C@H](OCCOC)CC1)OC(C)(C)C
MDL No. :MFCD08669815

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Application In Synthesis of [ 1212413-55-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1212413-55-2 ]

[ 1212413-55-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 109431-87-0 ]
  • [ 6482-24-2 ]
  • [ 1212413-55-2 ]
YieldReaction ConditionsOperation in experiment
51% To a stirred solution of NaH (3.8 g, 95 mmol, 60% in mineral oil w/w) in THF (20 ml) under N2atmosphere at 0 C, was added tert-butyl (R)-3-hydroxypyrrolidine-l- carboxylate (step 1, 4.5 g, 24 mmol) in THF (40 ml). After 30 minutes l-bromo-2- methoxyethane (3.4 ml, 36 mmol) was added, the reaction mixture was slowly allowed to attain to room temperature and stirred for overnight. After completion of the reaction (monitored by TLC), the reaction mixture was quenched by addition of saturated NH4C1 solution at 0 C. The solution was extracted with EtOAc (2x100 mL), the combined organic phases were washed with brine, dried over Na2S04and concentrated under reduced pressure to give the crude product. Purification by flash chromatography with EtOAc-hexane (2: 8) as an eluent to afford the desired product (3.0 g, yield: 51%) as an oil. 1H MR (300 MHz, CDC13): δ 4.10-4.05 (m, 1H), 3.60-3.52 (m, 4H), 3.45-3.36 (m, 4H), 3.38 (s, 3H), 2.02-1.93 (m, 2H), 1.45 (s, 9H).
 

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