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[ CAS No. 1214741-21-5 ] {[proInfo.proName]}

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Chemical Structure| 1214741-21-5
Chemical Structure| 1214741-21-5
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Product Details of [ 1214741-21-5 ]

CAS No. :1214741-21-5 MDL No. :MFCD20040525
Formula : C12H19NO3 Boiling Point : -
Linear Structure Formula :- InChI Key :DAGVYBNUTMALEB-MAZPRZIYSA-N
M.W : 225.28 Pubchem ID :77174618
Synonyms :

Calculated chemistry of [ 1214741-21-5 ]

Physicochemical Properties

Num. heavy atoms : 16
Num. arom. heavy atoms : 0
Fraction Csp3 : 0.75
Num. rotatable bonds : 2
Num. H-bond acceptors : 3.0
Num. H-bond donors : 1.0
Molar Refractivity : 64.13
TPSA : 49.77 Ų

Pharmacokinetics

GI absorption : High
BBB permeant : Yes
P-gp substrate : No
CYP1A2 inhibitor : No
CYP2C19 inhibitor : No
CYP2C9 inhibitor : No
CYP2D6 inhibitor : No
CYP3A4 inhibitor : No
Log Kp (skin permeation) : -6.77 cm/s

Lipophilicity

Log Po/w (iLOGP) : 1.76
Log Po/w (XLOGP3) : 1.28
Log Po/w (WLOGP) : 0.87
Log Po/w (MLOGP) : 1.33
Log Po/w (SILICOS-IT) : 1.16
Consensus Log Po/w : 1.28

Druglikeness

Lipinski : 0.0
Ghose : None
Veber : 0.0
Egan : 0.0
Muegge : 0.0
Bioavailability Score : 0.55

Water Solubility

Log S (ESOL) : -1.91
Solubility : 2.76 mg/ml ; 0.0123 mol/l
Class : Very soluble
Log S (Ali) : -1.92
Solubility : 2.68 mg/ml ; 0.0119 mol/l
Class : Very soluble
Log S (SILICOS-IT) : -1.12
Solubility : 17.0 mg/ml ; 0.0753 mol/l
Class : Soluble

Medicinal Chemistry

PAINS : 0.0 alert
Brenk : 1.0 alert
Leadlikeness : 1.0
Synthetic accessibility : 3.89

Safety of [ 1214741-21-5 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P280 UN#:N/A
Hazard Statements:H302-H317 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 1214741-21-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 1214741-21-5 ]
  • Downstream synthetic route of [ 1214741-21-5 ]

[ 1214741-21-5 ] Synthesis Path-Upstream   1~5

  • 1
  • [ 1214741-20-4 ]
  • [ 1214741-21-5 ]
YieldReaction ConditionsOperation in experiment
83%
Stage #1: With lithium tri(t-butoxy)aluminum hydride In tetrahydrofuran at -20 - 0℃; for 14 h; Inert atmosphere
Stage #2: With Glauber's salt In tetrahydrofuran at 0 - 20℃; for 2 h; Inert atmosphere
To a 500 mL three-necked flask (1) equipped with an agitator, thermometer, and a nitrogen inlet were added XVI (30.0 g, 132 mmol) and THF (300 mL). After cooling mixture to −20° C., lithium tri(t-butoxy)aluminum hydride (1 M THF; 162 mL) was added over 2 h while maintaining the temperature around −20° C. Temperature was then raised to 0° C. over 12 h. The reaction is quenched with the addition of EtOAc (12.0 mL) over 30 min, followed by agitation for 30 min at 0° C., and then slow addition of glacial AcOH (12.0 mL) over 30 min. To another 1-L three-necked flask (2) equipped with an agitator, thermometer, and a nitrogen inlet were added finely ground sodium sulfate decahydrate (30 g, 93 mol) and THF (150 mL) at 0° C. The reaction mixture in flask (1) was slowly transferred to flask (2) containing the sodium sulfate decahydrate solution while maintaining the temperature at 0° C. The temperature of flask (2) was raised over a 1 h period and agitated for 1 h at 20° C. The contents of flask (2) were filtered, the wet cake was washed three times with THF (180 mL, 120 mL, and then 120 mL), and the filtrates were combined and concentrated in vacuum to 60 mL. To a 1000 mL three-necked flask (3) equipped with an agitator, thermometer, and a nitrogen inlet was added water (300 mL). The mixture from flask (2) was cooled to 5° C. and then added to the water with high agitation over a 2 h period, whereupon the product precipitated. The slurry was concentrated in vacuum to 450 mL and the solid was isolated via filtration. The wet cake was dried at 50° C. for 12 h to afford 25.1 g of the compound of formula H as a white/off white solid in 83percent yield. Mp 88° C. 1H-NMR 500 MHz (DMSO-d6) δ 6.92 (d, J=3.9 Hz, 1H), 6.03 (dd, J=15.8, 11.1 Hz, 1H), 5.36 (d, J=3.9 Hz, 1H), 5.24 (d, J=17.6 Hz, 1H), 5.11 (d, J=11.1 Hz, 1H), 4.75 (s, 1H), 2.72 (ddd, J=16.8, 10.2, 8.7 Hz, 1H), 2.28 (ddd, J=16.7, 10.5, 3.7 Hz, 1H), 2.45 (ddd, J=12.8, 10.4, 8.9 Hz, 1H), 1.82 (ddd, J=12.9, 10.5, 3.7 Hz, 1H), 0.85 (s, 9H). 13C-NMR (125 MHz DMSO-d6) δ 180.7, 142.1, 113.3, 96.2, 93.9, 73.6, 34.5, 33.2, 26.8, 25.9 ppm. LC/MS calculated mass for C12H20NO3 [M+H]+(m/z) 226.14377. found 226.14398.
Reference: [1] Patent: US2014/31549, 2014, A1, . Location in patent: Paragraph 0150
  • 2
  • [ 98-79-3 ]
  • [ 1214741-21-5 ]
Reference: [1] Patent: US2014/31549, 2014, A1,
  • 3
  • [ 630-19-3 ]
  • [ 1214741-21-5 ]
Reference: [1] Patent: US2014/31549, 2014, A1,
  • 4
  • [ 171284-84-7 ]
  • [ 1214741-21-5 ]
Reference: [1] Patent: US2014/31549, 2014, A1,
  • 5
  • [ 1214741-19-1 ]
  • [ 1214741-21-5 ]
Reference: [1] Patent: US2014/31549, 2014, A1,
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