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[ CAS No. 1216121-34-4 ] {[proInfo.proName]}

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Chemical Structure| 1216121-34-4
Chemical Structure| 1216121-34-4
Structure of 1216121-34-4 * Storage: {[proInfo.prStorage]}
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Product Details of [ 1216121-34-4 ]

CAS No. :1216121-34-4 MDL No. :MFCD14543550
Formula : C8H4BrN3 Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 222.04 Pubchem ID :-
Synonyms :

Safety of [ 1216121-34-4 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501 UN#:N/A
Hazard Statements:H302-H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 1216121-34-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1216121-34-4 ]

[ 1216121-34-4 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 913835-67-3 ]
  • [ 1216121-34-4 ]
  • [ 1428267-39-3 ]
YieldReaction ConditionsOperation in experiment
39% With tetrakis(triphenylphosphine) palladium(0); sodium carbonate In ethanol; toluene at 80℃; for 2h; To a 50 mL round bottom flask was added boronic acid 1 (417 mg, 1.46 mmol), bromide 3 (270 mg, 1.21 mmol), Pd(Ph3P)4 (140 mg, 0.12 mmol), Na2C03 (lM, 7.3 mL), toluene (24.0 mL) and EtOH (12.0 mL). The resultant brown mixture turned black upon heating to 80°C. The reaction mixture was stirred at this temperature for 2 hours and cooled to room temperature. The organic layer was separated and the aqueous was extracted with EtOAc (2 x 20 mL). All the organics were combined, dried over anhydrous Na2S04, filtered. The solvent was removed by rotary evaporator to yield yellow residue, which was purified by column chromatography on silica gel (hexanes: ethyl acetate) to provide 247-139-002 (181 mg, 39%) as yellow solid. ¾ NMR (300 MHz, CDC13): 8.54 (s, 1H), 8.30 (s, 1H), 8.14 (s, 1H), 7.70-7.60 (m, 2H), 7.57 (dd, 1H), 7.40 (dd, 1H), 6.74 (s, 1H), 1.46 (s, 9H); R 0.40 (hexanes: EtOAc, 1 : 1) [UV].
39% With tetrakis(triphenylphosphine) palladium(0); sodium carbonate In ethanol; water; toluene at 80℃; for 2h; 6.46. tert-Butyl 6-cyano-2-(2-cyanoimidazo[1,2-a]pyridin-6-yl)-1H-indole-1-carboxylate (I-17) To a 50mL round bottom flask was added 1-(tert-butoxycarbonyl)-6-cyano-1H-indol-2-ylboronic acid (6) (417mg, 1.46 mmol), 6-bromoimidazo[1,2-a]pyridine-2-carbonitrile (11) (270 mg, 1.21 mmol), Pd(Ph3P)4 (140mg, 0.12 mmol), Na2CO3 (1M, 7.3 mL), toluene (24.0 mL) and EtOH (12.0 mL). The resultant brownmixture turned black upon heating to 80°C. The reaction mixture was stirred at this temperature for 2 hand cooled to room temperature. The organic layer was separated and the aqueous was extracted withEtOAc (2 x 20 mL). All the organics were combined, dried over anhydrous Na2SO4, filtered. The solventwas removed by rotary evaporator to yield yellow residue, which was purified by columnchromatography on silica gel (hexanes: ethyl acetate) to provide I-17 (181 mg, 39%) as yellow solid;
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