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Chemical Structure| 121639-09-6 Chemical Structure| 121639-09-6

Structure of 121639-09-6

Chemical Structure| 121639-09-6

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Product Details of [ 121639-09-6 ]

CAS No. :121639-09-6
Formula : C10H13NO3
M.W : 195.22
SMILES Code : CC(NC1=CC=CC(OC)=C1OC)=O
MDL No. :MFCD05864317

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Application In Synthesis of [ 121639-09-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 121639-09-6 ]

[ 121639-09-6 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 6299-67-8 ]
  • [ 75-36-5 ]
  • [ 121639-09-6 ]
YieldReaction ConditionsOperation in experiment
62% With pyridine; In dichloromethane; at 0 - 20℃;Inert atmosphere; General procedure: To a solution of 3,4-dimethoxyaniline (0.77 g, 5.0 mmol) in CH2Cl2 (8.0 mL) was added pyridine (4.0 mL, 50 mmol) and benzoyl chloride (0.70 g, 5.0 mmol) in CH2Cl2 (2.0 mL) at 0 C, and stirred at room temperature under argon. The reaction was monitored by TLC. The resulting mixture was quenched with 1M HCl, extracted with CH2Cl2 (3 x 20 mL). The combined organic layer was washed with brine, dried over MgSO4, and concentrated under vacuum. The crude compounds were purified with silica gel column chromatography (EtOAc : hexane = 1 : 2) and recrystallized from EtOAc/hexane to get the target anilide 1a (0.62 g, 48%).
 

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