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[ CAS No. 1219025-18-9 ] {[proInfo.proName]}

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Chemical Structure| 1219025-18-9
Chemical Structure| 1219025-18-9
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Product Details of [ 1219025-18-9 ]

CAS No. :1219025-18-9 MDL No. :
Formula : C45H58NP Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 643.92 Pubchem ID :-
Synonyms :

Safety of [ 1219025-18-9 ]

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Application In Synthesis of [ 1219025-18-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1219025-18-9 ]

[ 1219025-18-9 ] Synthesis Path-Downstream   1~24

  • 1
  • [ 1219025-37-2 ]
  • [ 1219025-18-9 ]
YieldReaction ConditionsOperation in experiment
91% Stage #1: C46H57O2P With sodium azide; sulfuric acid In chloroform at 40℃; for 5.5h; Reflux; Stage #2: With water; sodium hydroxide In chloroform at 0℃;
With sodium azide; sulfuric acid In chloroform Reflux;
  • 2
  • [ 1121-60-4 ]
  • [ 1219025-18-9 ]
  • [ 1298133-21-7 ]
YieldReaction ConditionsOperation in experiment
92% With sodium tris(acetoxy)borohydride In 1,2-dichloro-ethane at 20℃; Inert atmosphere;
92% With sodium tris(acetoxy)borohydride In 1,2-dichloro-ethane at 20℃; for 6h; Inert atmosphere; 1 Example 1: Synthesis of (R)-N-(pyridyl-2-methyl)-7-di-(3,5-di-tert-butylphenyl)phosphino-7-amino-1,1'-spiro-dihydro-indene (Ia) Example 1 Synthesis of (R)-N-(pyridyl-2-methyl)-7-di-(3,5-di-tert-butylphenyl)phosphino-7-amino-1,1'-spiro-dihydro-indene (Ia) Under nitrogen atmosphere, (R)-7-di-(3,5-di-tert-butylphenyl)phosphino-7'-amino-1,1'-spiro-dihydro-indene (966 mg, 1.5 mmol), sodium triacetoxyborohydride (509 mg, 2.4 mmol) and 6 ml 1,2-dichloroethane were weighed into a 50 ml dry two-neck bottle. After the solid was dissolved by stirring at room temperature, pyridylaldehyde was added (161 mg, 1.5 mmol). After the reaction was stirred for 6 h at room temperature, the starting material was almost consumed (monitored by TLC, petroleum ether : ethyl acetate = 7:1). The reaction was quenched by saturated aqueous solution of sodium bicarbonate, extracted by ethyl acetate, and dried by anhydrous magnesium sulfate. After desolventization, 1.01 g white solid was obtained by purification of the resulting solid through silica gel column chromatography (petroleum ether : ethyl acetate = 10:1, 2% triethylamine), with a yield of 92%. Mp 172-174 °c; [α]20,D +172 (c 0.5, CH2Cl2); 1H NMR (400 mhz, cdcl3) δ 8.30 (d, J= 4.8 Hz, 1H, Ar-H), 7.44-7.39 (m, 1H, Ar-H), 7.31 (d, J = 7.2 Hz, 1H, Ar-H), 7.26-7.19 (m, 3H, Ar-H), 7.12-7.06 (m, 2H, Ar-H), 7.02-6.99 (m, 1H, Ar-H), 6.88-6.84 (m, 3H, Ar-H), 6.77-6.75 (dd, J= 1.6, 7.6 Hz, 2H, Ar-H), 6.68 (d, J= 9.2 Hz, 1H, Ar-H), 6.10 (d, J = 8.0 Hz, 1H, Ar-H), 4.20 (t, J = 5.2 Hz, 1H), 3.97 (dd, J = 6, 16.4 Hz, 1H), 3.73 (dd, J = 4.4, 16.4 Hz, 1H), 3.13-2.76 (m, 4H), 2.49-2.40(m, 1H), 2.19-2.09 (m, 3H), 1.09 (s, 18H), 1.16 (s, 18H); 31P NMR (162 mhz, cdcl3) δ -18.17 (s); 13C NMR (100 mhz, cdcl3) δ 155.8, 152.5 (d, J = 24.3 Hz), 149.9 (d, J = 6.3 Hz), 148.9, 144.3, 144.2, 144.1, 138.2 (d, J= 11.7 Hz), 136.1, 135.2, 134.9, 133.8, 132.6 (d, J= 3.4 Hz), 128.4, 128.1, 128.0, 127.9, 126. 9, 125.7, 122.2, 121.5, 121.5, 120.7, 113.9, 108.6, 61.7 (d, J = 3.3 Hz), 48.5, 38.6 (d, J = 3.4 Hz), 36.1, 34.7 (d, J = 3.8 Hz), 31.4 (d, J = 2.4 Hz), 30.92, 31.36. HRMS (ESI) calcd for C51H63N2P[M + H]+: 735.4802; Found: 735.4804.
  • 3
  • [ 1122-72-1 ]
  • [ 1219025-18-9 ]
  • [ 1298133-26-2 ]
YieldReaction ConditionsOperation in experiment
95% With sodium tris(acetoxy)borohydride In 1,2-dichloro-ethane at 20℃; Inert atmosphere;
  • 4
  • [ 55589-47-4 ]
  • [ 1219025-18-9 ]
  • [ 1298133-36-4 ]
  • 5
  • [ 5470-96-2 ]
  • [ 1219025-18-9 ]
  • [ 1298133-32-0 ]
YieldReaction ConditionsOperation in experiment
98% With sodium tris(acetoxy)borohydride In 1,2-dichloro-ethane at 20℃; Inert atmosphere;
  • 6
  • [ 67141-22-4 ]
  • [ 1219025-18-9 ]
  • [ 1298133-38-6 ]
YieldReaction ConditionsOperation in experiment
95% With sodium tris(acetoxy)borohydride In 1,2-dichloro-ethane at 20℃; Inert atmosphere;
  • 7
  • [ 1219025-18-9 ]
  • [ 153646-82-3 ]
  • [ 1298133-30-8 ]
  • 8
  • [ 1219025-18-9 ]
  • [ 1220975-02-9 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: pyridine / toluene / 0 - 20 °C / Inert atmosphere 2: lithium aluminium tetrahydride / tetrahydrofuran / 0 °C / Reflux
  • 9
  • [ 1219025-18-9 ]
  • [ 1220975-03-0 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 4 steps 1: pyridine / toluene / 0 - 20 °C / Inert atmosphere 2: lithium aluminium tetrahydride / tetrahydrofuran / 0 °C / Reflux 3: pyridine / toluene / 0 - 20 °C / Inert atmosphere 4: lithium aluminium tetrahydride / tetrahydrofuran / 0 °C / Reflux
  • 10
  • [ 1219025-18-9 ]
  • [ CAS Unavailable ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1: pyridine / toluene / 0 - 20 °C / Inert atmosphere 2: lithium aluminium tetrahydride / tetrahydrofuran / 0 °C / Reflux 3: pyridine / toluene / 0 - 20 °C / Inert atmosphere
  • 11
  • [ 1219025-18-9 ]
  • [ 541-41-3 ]
  • [ CAS Unavailable ]
YieldReaction ConditionsOperation in experiment
With pyridine In toluene at 0 - 20℃; Inert atmosphere;
  • 12
  • [ 30893-63-1 ]
  • [ 1219025-18-9 ]
  • [ 1809609-61-7 ]
YieldReaction ConditionsOperation in experiment
With pyridine In dichloromethane at 0 - 20℃; Inert atmosphere;
  • 13
  • [ 1219025-18-9 ]
  • [ 819073-37-5 ]
  • [ 1809609-60-6 ]
YieldReaction ConditionsOperation in experiment
With pyridine In dichloromethane at 0 - 20℃; Inert atmosphere;
  • 14
  • [ 1219025-18-9 ]
  • [ 1809609-58-2 ]
  • [ 1809609-59-3 ]
YieldReaction ConditionsOperation in experiment
With pyridine In dichloromethane at 0 - 20℃; Inert atmosphere;
  • 15
  • [ 54256-37-0 ]
  • [ 1219025-18-9 ]
  • [ 1809609-67-3 ]
YieldReaction ConditionsOperation in experiment
With pyridine In dichloromethane at 0 - 20℃; Inert atmosphere;
  • 16
  • [ 7031-28-9 ]
  • [ 1219025-18-9 ]
  • [ 1809609-70-8 ]
YieldReaction ConditionsOperation in experiment
With pyridine In dichloromethane at 0 - 20℃; Inert atmosphere;
  • 17
  • [ 69077-44-7 ]
  • [ 1219025-18-9 ]
  • [ 1809609-68-4 ]
YieldReaction ConditionsOperation in experiment
With pyridine In dichloromethane at 0 - 20℃; Inert atmosphere;
  • 18
  • [ 1219025-18-9 ]
  • [ 1809609-53-7 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: hydrogen; Pd/C / ethanol / 4 h / 20 °C 2: indium(III) chloride / 1,2-dichloro-ethane / 2 h / Inert atmosphere; Reflux
  • 19
  • [ 51673-84-8 ]
  • [ 1219025-18-9 ]
  • [ 1809609-71-9 ]
YieldReaction ConditionsOperation in experiment
97% With Pd/C; hydrogen In ethanol at 20℃; for 4h;
  • 20
  • [ 7031-27-8 ]
  • [ 1219025-18-9 ]
  • [ 1809609-55-9 ]
YieldReaction ConditionsOperation in experiment
With pyridine In dichloromethane at 0 - 20℃; Inert atmosphere;
  • 21
  • [ 1219025-18-9 ]
  • [ 2306482-16-4 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 4 steps 1.1: acetic acid / methanol; toluene / 5 h / 20 °C / Inert atmosphere 1.2: 12 h / 40 °C / Inert atmosphere 2.1: lithium hydroxide monohydrate / tetrahydrofuran; water / 12 h / 80 °C / Sealed tube 3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 12 h / 20 °C / Inert atmosphere 4.1: triethylamine; dmap; methanesulfonyl chloride / dichloromethane / 0 - 20 °C
  • 22
  • [ 1219025-18-9 ]
  • [ 2306482-26-6 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 4 steps 1.1: acetic acid / methanol; toluene / 5 h / 20 °C / Inert atmosphere 1.2: 12 h / 40 °C / Inert atmosphere 2.1: lithium hydroxide monohydrate / tetrahydrofuran; water / 12 h / 80 °C / Sealed tube 3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 12 h / 20 °C / Inert atmosphere 4.1: triethylamine; dmap; methanesulfonyl chloride / dichloromethane / 0 - 20 °C
  • 23
  • [ 1219025-18-9 ]
  • [ 2306482-35-7 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 4 steps 1.1: acetic acid / methanol; toluene / 5 h / 20 °C / Inert atmosphere 1.2: 12 h / 40 °C / Inert atmosphere 2.1: lithium hydroxide monohydrate / tetrahydrofuran; water / 12 h / 80 °C / Sealed tube 3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 12 h / 20 °C / Inert atmosphere 4.1: triethylamine; dmap; methanesulfonyl chloride / dichloromethane / 0 - 20 °C
  • 24
  • [ 1219025-18-9 ]
  • [ 2306482-45-9 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 4 steps 1.1: acetic acid / methanol; toluene / 5 h / 20 °C / Inert atmosphere 1.2: 12 h / 40 °C / Inert atmosphere 2.1: lithium hydroxide monohydrate / tetrahydrofuran; water / 12 h / 80 °C / Sealed tube 3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 12 h / 20 °C / Inert atmosphere 4.1: triethylamine; dmap; methanesulfonyl chloride / dichloromethane / 0 - 20 °C
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Reason: Optical isomers