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Chemical Structure| 1220517-81-6 Chemical Structure| 1220517-81-6

Structure of 1220517-81-6

Chemical Structure| 1220517-81-6

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Product Details of [ 1220517-81-6 ]

CAS No. :1220517-81-6
Formula : C8H9ClN4S
M.W : 228.70
SMILES Code : CSC1=NC(Cl)=C2C(N(CC)N=C2)=N1
MDL No. :MFCD19105129

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* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1220517-81-6 ]

[ 1220517-81-6 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 85426-79-5 ]
  • [ 75-03-6 ]
  • [ 1220517-81-6 ]
YieldReaction ConditionsOperation in experiment
77% With sodium hydride; In acetonitrile; mineral oil; at 5 - 50℃; for 3h; To a solution of (27i') (1.0 g, 5.0 mmol) in acetonitrile (10 mL) cooled at 5C on an ice bath, were added NaH (144 mg, 6.0 mmol) and iodoethane (0.60 mL, 7.5 mmol). After 3 hours stirring at 50C, acetonitrile was evaporated to dryness under vacuum and the residue was partitioned between water (50 mL) and dichloromethane (2 x 50 mL). The combined organic layers were dried and evaporated to dryness under vacuum. The residue was purified by silica gel column chromatography.Yield: 11%.Melting point: 92-93.5C.H NMR (DMSO -d6) d 1.43 (t, J=7.2 Hz, 3H, NCH2C/ ,), 2.62 (s, 3H, S CH3), 4.42 (q, J=7.2 Hz, 2H, NCH2CH3), 8.34 (s, 1H, CH).13C NMR (DMSO -d6) d 13.9 (SCH3), 14.4 (NCH2CH3), 42.2 (NCH2CH3), 110.1 (C-3a), 132.3 (C-3), 153.0 (C-4/C-7a), 168.7 (C-6).
 

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