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Chemical Structure| 1221171-93-2 Chemical Structure| 1221171-93-2

Structure of 1221171-93-2

Chemical Structure| 1221171-93-2

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Product Details of [ 1221171-93-2 ]

CAS No. :1221171-93-2
Formula : C6H4ClF3N2O
M.W : 212.56
SMILES Code : NC1=CC=C(Cl)N=C1OC(F)(F)F
MDL No. :MFCD22571786

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Application In Synthesis of [ 1221171-93-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1221171-93-2 ]

[ 1221171-93-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1221171-93-2 ]
  • [ 1221171-94-3 ]
YieldReaction ConditionsOperation in experiment
80% With ammonium formate;palladium 10% on activated carbon; In methanol; at 55℃; for 16.0h; 3-amino-2-trifluoromethoxy pyridine (40); At 25 0C, palladium (10% on charcoal, 730 mg) was added with stirring to a solution of 5-amino-2-chloro-6-trifluoromethoxypyridine (39, 1.6 g, 7.4 mmol) and ammonium formate (940 mg, 14.8 mmol, 2 eq) in methanol (12 mL). The reaction mixture was stirred for 16 h at 55 0C before being filtrated under suction and the solvent evaporated.The residue was partitioned between ethyl acetate (2chi 20 mL) and water (30 mL). The combined organic layers were dried over sodium sulfate before being evaporated to afford pure 3-amino-2-trifluoromethoxypyridine (40, 1.05 g, 5.9 mmol, 80%) as a yellow oil.1H NMR (CDCl3, 300 MHz): delta = 7.68 (dd, J = 4.6, 1.7 Hz, 1 H), 7.09 (dd, J = 7.8, 1.7 Hz 1 H), 7.02 (dd, J= 7.8, 4.6 Hz, 1 H), 3.90 (bs, 2 H). - 19F NMR (CDCl3, 282 MHz): delta = -56.2 - 13C NMR (CDCl3, 75 MHz): delta = 144.6, 138.2, 132.2, 124.1, 122.4, 120.3 (q, J= 262 Hz). - C6H5F3N2O (178): calcd. (%) C 40.46, H 2.83, N 15.73; found C 41.28,H 2.90, N 16.02.
 

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