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Chemical Structure| 1221232-29-6 Chemical Structure| 1221232-29-6

Structure of 1221232-29-6

Chemical Structure| 1221232-29-6

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Product Details of [ 1221232-29-6 ]

CAS No. :1221232-29-6
Formula : C9H5BrClN
M.W : 242.50
SMILES Code : ClC1=CN=CC2=C1C=C(C=C2)Br
MDL No. :MFCD28661254

Safety of [ 1221232-29-6 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501

Application In Synthesis of [ 1221232-29-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1221232-29-6 ]

[ 1221232-29-6 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1221232-29-6 ]
  • [ 145214-05-7 ]
  • 2-(4-chloroisoquinolin-6-yl)oxazole [ No CAS ]
YieldReaction ConditionsOperation in experiment
63% With tetrakis(triphenylphosphine) palladium(0); In 1,4-dioxane; at 100℃; for 11h; Example 25 2-(4-(4-(1-methyl-1H-pyrazol-4-yl)phenyl)isoquinolin-6-yl)oxazole (119) 2-(4-chloroisoquinolin-6-yl)oxazole To 6-bromo-4-chloroisoquinoline (109 mg, 0.449 mmol) and Pd(PPh3)4 (26.0 mg, 0.022 mmol) in a microwave vial were added degassed 1,4-dioxane (1.80 mL) and <strong>[145214-05-7]2-(tributylstannyl)oxazole</strong> (206 μl, 0.674 mmol). The reaction mixture was heated in an oil bath at 100 C. for 11 h before being concentrated. The crude was purified via biotage column chromatography (dichloromethane/ethyl acetate 95/5 to 50/50) to give the title compound (65 mg, 63% yield).
 

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