Home Cart 0 Sign in  

[ CAS No. 1224944-43-7 ] {[proInfo.proName]}

,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
Chemical Structure| 1224944-43-7
Chemical Structure| 1224944-43-7
Structure of 1224944-43-7 * Storage: {[proInfo.prStorage]}
Cart0 Add to My Favorites Add to My Favorites Bulk Inquiry Inquiry Add To Cart

Quality Control of [ 1224944-43-7 ]

Related Doc. of [ 1224944-43-7 ]

Alternatived Products of [ 1224944-43-7 ]

Product Details of [ 1224944-43-7 ]

CAS No. :1224944-43-7 MDL No. :MFCD31699005
Formula : C6H4N3NaO Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 157.11 Pubchem ID :-
Synonyms :

Safety of [ 1224944-43-7 ]

Signal Word: Class:
Precautionary Statements: UN#:
Hazard Statements: Packing Group:

Application In Synthesis of [ 1224944-43-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 1224944-43-7 ]
  • Downstream synthetic route of [ 1224944-43-7 ]

[ 1224944-43-7 ] Synthesis Path-Upstream   1~3

  • 1
  • [ 1224944-43-7 ]
  • [ 29274-22-4 ]
YieldReaction ConditionsOperation in experiment
85% With acetic acid In water for 0.25 h; Inert atmosphere Sodium pyrazolo[l,5-α]pyrinidin-5-olate (13.47g) was dissolved in 500 mL of acetic acid and 100 mL of water, stirred 15 minutes then evaporated to dryness under vacuum. The residue was suspended in 300 mL of 9:1 dichloromethane methanol and vacuum filtered through silica gel to remove sodium acetate. The silica gel pad was washed with 700 mL of additional dichloromethane methanol solution. The combined dichloromethane methanol solution was concentrated to dryness. The solid product was suspended in 1 :1 hexane: dichloromethane and filtered to yield 9.9 g (85percent) pyrazolo[l,5- α]pyrimidin-5(4H)-one. LCMS (ESI) m+H = 136.0; 1H NMR (400 MHz, DMSO-^) δ: 12.1 (s broad exchangeable, 1 H), 8.47 (d, 1 H, J=7.9), 7.75 (d, 1 H, J=I.9), 5.94 (d, IH, J=7.5), 5.81 (d, 1 H, J=1.7).
85% With acetic acid In water for 0.25 h; Inert atmosphere Sodium pyrazolo[1,5-a]pyrimidin-5-olate (13.47 g) was dissolved in 500 mL of acetic acid and 100 mL of water, stirred 15 minutes then evaporated to dryness under vacuum. The residue was suspended in 300 mL of 9:1 dichloromethane:methanol and vacuum filtered through silica gel to remove sodium acetate. The silica gel pad was washed with 700 mL of additional dichloromethane:methanol solution. The combined dichloromethane:methanol solution was concentrated to dryness. The solid product was suspended in 1:1 hexane:dichloromethane and filtered to yield 9.9 g (85percent) pyrazolo[1,5-c]pyrimidin-5(4H)-one. LCMS (ESI) m+H=136.0; 1H NMR (400 MHz, DMSO-d6) δ: 12.1 (s broad exchangeable, 1H), 8.47 (d, 1H, J=7.9), 7.75 (d, 1H, J=1.9), 5.94 (d, 1H, J=7.5), 5.81 (d, 1H, J=1.7).
Reference: [1] Patent: WO2010/51549, 2010, A1, . Location in patent: Page/Page column 42; 75
[2] Patent: US2012/22043, 2012, A1, . Location in patent: Page/Page column 33
[3] Journal of Medicinal Chemistry, 2012, vol. 55, # 22, p. 10090 - 10107
  • 2
  • [ 1224944-43-7 ]
  • [ 1223405-08-0 ]
Reference: [1] Patent: US2017/281632, 2017, A1,
  • 3
  • [ 1224944-43-7 ]
  • [ 1224944-51-7 ]
Reference: [1] Patent: US2012/22043, 2012, A1,
Same Skeleton Products
Historical Records