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Chemical Structure| 1227511-52-5 Chemical Structure| 1227511-52-5

Structure of 1227511-52-5

Chemical Structure| 1227511-52-5

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Product Details of [ 1227511-52-5 ]

CAS No. :1227511-52-5
Formula : C7H6FNO3
M.W : 171.13
SMILES Code : O=C(O)C1=NC=C(OC)C=C1F
MDL No. :MFCD16611229

Safety of [ 1227511-52-5 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H332-H335
Precautionary Statements:P261-P280-P305+P351+P338

Application In Synthesis of [ 1227511-52-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1227511-52-5 ]

[ 1227511-52-5 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 745784-04-7 ]
  • [ 1227511-52-5 ]
  • 2
  • [ 745784-04-7 ]
  • [ 74-88-4 ]
  • [ 1227511-52-5 ]
  • 5-fluoro-3-methoxypyridine-2-carboxylic acid [ No CAS ]
YieldReaction ConditionsOperation in experiment
To a solution of methyl 3-fluoro-5-methoxypicolinate (1.18 g, 6.37 mmol) and methyl 5-fluoro-3-methoxypicolinate in MeOH (30 mL, Aldrich) and water (10 mL) at 0 C was added lithium hydroxide hydrate (0.53 g, 12.74 mmol, Aldrich). After addition, the mixture was then stirred at room temperature for lh. The mixture was concentrated and H20 (25 mL) was added. The resulting mixture was adjusted to pH=5-6 by HC1 (2N). The mixture was concentrated and dried. The residue was dissolved in MeOH (100 mL), adsorbed onto silica, and purified by silica gel flash chromatography using a gradient of 0%-40% MeOH in DCM to give 1.67 g (white solid) of products as a mixture of 3-fluoro-5-methoxypicolinic acid and 5-fluoro-3-methoxypicolinic acid. MS (ESI, positive ion) m/z: 172.1 (M+H) observed for both isomers
  • 3
  • [ 298709-29-2 ]
  • [ 124-41-4 ]
  • [ 1227511-52-5 ]
  • 5-fluoro-3-methoxypyridine-2-carboxylic acid [ No CAS ]
 

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