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[ CAS No. 1229584-17-1 ] {[proInfo.proName]}

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Chemical Structure| 1229584-17-1
Chemical Structure| 1229584-17-1
Structure of 1229584-17-1 * Storage: {[proInfo.prStorage]}
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Product Details of [ 1229584-17-1 ]

CAS No. :1229584-17-1 MDL No. :MFCD18383629
Formula : C15H19BN2O2 Boiling Point : -
Linear Structure Formula :- InChI Key :ABLIMXXAJWRGPB-UHFFFAOYSA-N
M.W : 270.14 Pubchem ID :59619662
Synonyms :

Safety of [ 1229584-17-1 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P280-P305+P351+P338 UN#:N/A
Hazard Statements:H302 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 1229584-17-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1229584-17-1 ]

[ 1229584-17-1 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 73183-34-3 ]
  • [ 176961-53-8 ]
  • [ 1229584-17-1 ]
YieldReaction ConditionsOperation in experiment
36% With potassium acetate In dimethyl sulfoxide at 80℃; 167 2-(4-Bromo-phenyl)-lH-imidazole (300 mg, 1.3 mmol), bis(pinacolato)diboron (376 mg, 1.48 mmol), KOAc (400 mg, 4.03 mmol) and PdCl2(dppf) CH2Cl2 (50 mg, 0.067 mmol) were combined in DMSO (8 ml) and stirred t 800C overnight. EtOAc was added, washed with water, dried, evaporated and purified by silica gel chromatography eluting with 0-5% MeOH:DCM to give 116 mg (36%) of the title compound. 1H NMR (CDCl3, 300 MHz): δ 7.86 (s, 4H), 7.18 (s, 2H), 1.36 (s, 12H).
36% With potassium acetate In dimethyl sulfoxide at 80℃; 167 Preparation of 2-[4-(4,4,5,5-tetramethyl-[l,3,2]dioxaborolan-2-yl)-phenyl]-lH-imidazole (Intermediate CG)[0394] 2-(4-Bromo-phenyl)-lH-imidazole (300 mg, 1.3 mmol), bis(pinacolato)diboron (376 mg, 1.48 mmol), KOAc (400 mg, 4.03 mmol) and PdCl2(dppf) CH2Cl2 (50 mg, 0.067 mmol) were combined in DMSO (8 ml) and stirred t 80°C overnight. EtOAc was added, washed with water, dried, evaporated and purified by silica gel chromatography eluting with 0-5 % MeOH:DCM to give 116 mg (36%) of the title compound. 1H NMR (CDC13, 300 MHz): δ 7.86 (s, 4H), 7.18 (s, 2H), 1.36 (s, 12H).
36% With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium acetate In dimethyl sulfoxide at 80℃; 167 Preparation of Intermediate A: 2-[4-(4,4,5,5-tetramethyl-[l,3,2]dioxaborolan-2-yl)- phenyl]-lH-imidazole In reference to Scheme 29, 2-(4-Bromo-phenyl)-lH-imidazole (300 mg, 1.3 mmol), bis(pinacolato)diboron (376 mg, 1.48 mmol), KOAc (400 mg, 4.03 mmol) and PdCl2(dppf) CH2Cl2 (50 mg, 0.067 mmol) were combined in DMSO (8 ml) and stirred t 80°C overnight. EtOAc was added, washed with water, dried, evaporated and purified by silica gel chromatography eluting with 0-5% MeOH:DCM to give 116 mg (36%) of the title compound. XH NMR (CDC13, 300 MHz): δ 7.86 (s, 4H), 7.18 (s, 2H), 1.36 (s, 12H).
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