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Chemical Structure| 1229607-86-6 Chemical Structure| 1229607-86-6

Structure of 1229607-86-6

Chemical Structure| 1229607-86-6

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Product Details of [ 1229607-86-6 ]

CAS No. :1229607-86-6
Formula : C19H18ClN3O3
M.W : 371.82
SMILES Code : O=C(NC1=C2C=CC=CC2=C(C=C1)OC3=NC(Cl)=NC=C3)OC(C)(C)C
MDL No. :MFCD31556242

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Application In Synthesis of [ 1229607-86-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1229607-86-6 ]

[ 1229607-86-6 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1229607-86-6 ]
  • [ 42237-85-4 ]
  • [ 1562520-06-2 ]
YieldReaction ConditionsOperation in experiment
57% With toluene-4-sulfonic acid; In tetrahydrofuran; at 65℃; for 24h; Intermediate J8(P): 3-Bromo-5-((4-((4-((iert-butoxycarbonyl)amino)naphthalen-1-yl)oxy) pyrimidin-2-yl)amino)benzoic acid. Intermediate G2(P) To a degassed solution of Intermediate G2(P) (1.5 g, 4.0 mmol) in anhydrous THF (20 mL) was added <strong>[42237-85-4]3-amino-5-bromobenzoic acid</strong> (1.57 g, 7.26 mmol) and p-TSA monohydrate (153 mg, 0.807 mmol) and the reaction mixture heated to 65C for 24 hr. The resulting mixture was cooled to RT and was diluted with NH3 in MeOH (0.7 M, 60 mL) and then evaporated in vacuo. The same process was repeated more and the residue so obtained was then triturated with MeOH (60 mL). The solid thus obtained was collected by filtration and dried in vacuo to provide the title compound, Intermediate J8(P), as a pale brown solid (1.33 g, 57%); R' 4.21 min (Method 3); m/z 552/554 (M+H)+, (ES+).
 

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