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CAS No. : | 123066-64-8 | MDL No. : | MFCD00220969 |
Formula : | C11H7F6N3 | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | XOXBUERZFCPKDR-UHFFFAOYSA-N |
M.W : | 295.18 | Pubchem ID : | 2740668 |
Synonyms : |
|
Chemical Name : | 4-(3,5-Bis(trifluoromethyl)-1H-pyrazol-1-yl)aniline |
Num. heavy atoms : | 20 |
Num. arom. heavy atoms : | 11 |
Fraction Csp3 : | 0.18 |
Num. rotatable bonds : | 3 |
Num. H-bond acceptors : | 7.0 |
Num. H-bond donors : | 1.0 |
Molar Refractivity : | 57.97 |
TPSA : | 43.84 Ų |
GI absorption : | High |
BBB permeant : | Yes |
P-gp substrate : | No |
CYP1A2 inhibitor : | Yes |
CYP2C19 inhibitor : | Yes |
CYP2C9 inhibitor : | No |
CYP2D6 inhibitor : | No |
CYP3A4 inhibitor : | No |
Log Kp (skin permeation) : | -5.94 cm/s |
Log Po/w (iLOGP) : | 2.15 |
Log Po/w (XLOGP3) : | 3.05 |
Log Po/w (WLOGP) : | 5.8 |
Log Po/w (MLOGP) : | 3.07 |
Log Po/w (SILICOS-IT) : | 2.8 |
Consensus Log Po/w : | 3.37 |
Lipinski : | 0.0 |
Ghose : | None |
Veber : | 0.0 |
Egan : | 0.0 |
Muegge : | 0.0 |
Bioavailability Score : | 0.55 |
Log S (ESOL) : | -3.8 |
Solubility : | 0.0467 mg/ml ; 0.000158 mol/l |
Class : | Soluble |
Log S (Ali) : | -3.64 |
Solubility : | 0.0681 mg/ml ; 0.000231 mol/l |
Class : | Soluble |
Log S (SILICOS-IT) : | -4.33 |
Solubility : | 0.0137 mg/ml ; 0.0000466 mol/l |
Class : | Moderately soluble |
PAINS : | 1.0 alert |
Brenk : | 1.0 alert |
Leadlikeness : | 0.0 |
Synthetic accessibility : | 2.12 |
Signal Word: | Warning | Class: | N/A |
Precautionary Statements: | P261-P280-P305+P351+P338 | UN#: | N/A |
Hazard Statements: | H302-H315-H319-H332-H335 | Packing Group: | N/A |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
94% | With palladium on activated charcoal; hydrogen In ethyl acetate at 20℃; for 2 h; | EtOAc (44 mL), Pd/C (1.3 g) and l-(4-nitrophenyl)-3,5- bis(trifluoromethyl)-lH-pyrazole (4.4 g, 13.5 mmol) are added under hydrogen atmosphere. After stirring at room temperature for 2 hours the resulting mixture is filtered under vacuo over a pad of celite, rinsed with EtOAc and evaporated to give compound 13 as a pale yellow solid (3.75 g, 12.7 mmol, 94percent). Analytical data:1H-NMR (300 MHz; CDC13): δ 7.22 (d, J 8.5 Hz, 2H), 7.00 (s, 1H), 6.72 (d, J 8.5 Hz, 2H). MS: M+l 296 |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
94% | With palladium on activated charcoal; hydrogen; In ethyl acetate; at 20℃; for 2h; | EtOAc (44 mL), Pd/C (1.3 g) and l-(4-nitrophenyl)-3,5- bis(trifluoromethyl)-lH-pyrazole (4.4 g, 13.5 mmol) are added under hydrogen atmosphere. After stirring at room temperature for 2 hours the resulting mixture is filtered under vacuo over a pad of celite, rinsed with EtOAc and evaporated to give compound 13 as a pale yellow solid (3.75 g, 12.7 mmol, 94%). Analytical data:1H-NMR (300 MHz; CDC13): delta 7.22 (d, J 8.5 Hz, 2H), 7.00 (s, 1H), 6.72 (d, J 8.5 Hz, 2H). MS: M+l 296 |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With triethylamine; In tetrahydrofuran; at 0 - 20℃; for 4h; | 4-chlorobenzoyl chloride (88 mg) and THF (2 ml) were added to a mixture of <strong>[123066-64-8]4-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]aniline</strong> (150 mg), triethylamine (57 mg) and THF (2 ml) under ice-cooling, followed by stirring at room temperature for 4 hours. Water was added to the reaction solution, the thus formed product was extracted with ethyl acetate and then the extract was washed with 1 N hydrochloric acid aqueous solution, saturated sodium bicarbonate aqueous solution and saturated brine in that order. The organic lager was dried over anhydrous magnesium sulfate and then concentrated under a reduced pressure. By recrystallizing the resulting residue from a mixed solvent of ethyl acetate and n-hexane, 4-chloro-4'-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]benzanilide (105 mg) was obtained as colorless powder crystals. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With 1-ethyl-3-(3-dimethylamino-propyl)-carbodiimide hydrochloride; In tetrahydrofuran; at 20℃; | A mixture of 1-tert-butoxycarbonylpiperidine-4-carboxylic acid (198 mg), <strong>[123066-64-8]4-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]aniline</strong> (206 mg), WSCD hydrochloride (172 mg) and THF (3 ml) was stirred overnight at room temperature. After adding ethyl acetate, the reaction solution was washed with water, saturated sodium bicarbonate aqueous solution, 1 N hydrochloric acid and saturated brine in that order. The organic layer was dried over anhydrous sodium sulfate and then concentrated under a reduced pressure. The resulting residue was purified by silica gel column chromtaography (eluent; n-hexane:ethyl acetate=7:1-5:1) to give tert-butyl 4-[4-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]phenylaminocarbonyl]piperidine-1-carboxylate (279 mg) as a colorless amorphous solid. 4 N hydrochloric acid ethyl acetate solution (2.60 ml) was added to a mixture of this solid (263 mg) and ethyl acetate (2.6 ml), followed by stirring at room temperature for 2 hours and 45 minutes. The reaction solution was concentrated under a reduced pressure, diethyl ether was added to the thus obtained residue, and the mixture was concentrated under a reduced pressure. By recrystallizing the resulting residue from a mixed solvent of ethyl acetate and n-hexane, [4'-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]piperidine]-4-carboxyanilide hydrochloride (201 mg) was obtained as colorless powder crystals. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With 1-ethyl-3-(3-dimethylamino-propyl)-carbodiimide hydrochloride; In 1,2-dichloro-ethane; at 20℃; | A mixture of <strong>[20485-41-0]4-methylthiazole-5-carboxylic acid</strong> (108 mg), 4-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]aniline (223 mg), WSCD hydrochloride 152 mg) and DCE (5 ml) was stirred overnight at room temperature. Water (10 ml) was added to the reaction mixture, and the thus formed product was extracted with a mixed solvent of diethyl ether (5 ml) and ethyl acetate (10 ml). The extract was washed with 1 N hydrochloric acid, saturated sodium hydrogencarbonate aqueous solution and saturated brine in that order. The resulting organic layer was dried over anhydrous magnesium sulfate and then concentrated under a reduced pressure. The thus obtained residue was purified by silica gel column chromatography (eluent; n-hexane:ethyl acetate=3:1-2:1) and then recrystallized from a mixed solvent of ethyl acetate and n-hexane to give 4-methyl-4'-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]thiazole-5-carboxyanilide (143 mg) as colorless needles. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
A mixture of 1-trityl-1H-imidazole-4-carboxylic acid (300 mg), <strong>[123066-64-8]4-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]aniline</strong> (200 mg), WSCD hydrochloride (162 mg), DMF (0.5 ml) and THF (4 ml) was stirred overnight at room temperature. Water (10 ml) was added to the reaction solution, the thus formed product was extracted with ethyl acetate and then the extract was washed with saturated brine. The organic layer was dried over anhydrous magnesium sulfate and then concentrated under a reduced pressure. The resulting residue was purified by silica gel column chromatography (eluent; n-hexane:ethyl acetate=3:1). Then, concentrated hydrochloric acid (0.1 ml) and acetone (3 ml) were added, followed by stirring overnignt at room temperature. The reaction solution was concentrated under a reduced pressure, diethyl ether was added to the thus obtained residue, and when the mixture was concentrated under a reduced pressure. A mixed solvent of ethanol and diethyl ether was added to the thus obtained residue, time insoluble matter was removed by filtration and then the filtrate was concentrated under a reduced pressure. The resulting residue was purified by silica gel column chromatography (eluent; n-hexane:ethyl acetate=1:1-2:3) and then recrystallized from a mixed solvent of ethyl acetate and n-hexane, thereby obtaining [4'-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]-1H-imidazole]-4-carboxyanilide (35 mg) as colorless powder crystals. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
19.6% | In dichloromethane; | Example 8 Synthesis of Morpholine-4-carboxylic Acid {4-[3.5-bis(trifluoromethyl)pyrazol-1-yl]phenyl}amide (Method F) To a solution of 1-(4'-aminophenyl)-3,5-bis(trifluoromethyl)pyrazole (0.300 g, 1.02 mmol) in of methylene chloride (5 mL) was added diisopropylethyl amine (0.18 mL, 1.0 mmol) followed by 4-morpholine carbonylchloride (0.11 mL, 1.0 mmol). The mixture was stirred at rt for 6 days, and diluted with ethyl acetate. It was then washed twice with water, dried over sodium sulfate and evaporated. Chromatography of the residue over silica gel (50% EtOAc/hexanes) gave the above-named compound (0.080 g, 19.6%) as a white solid: mp 185-186 C. NMR (CDCl3) delta 7.56 (2H, d), 7.44 (2H, d), 7.07 (1H, s), 6.51 (1H, s), 3.79 (4H, m), 3.54 (4H, m). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In N,N-dimethyl-formamide; | Example 10 Synthesis of {4-[3,5-bis(Trifluoromethyl)pyrazol-1-yl]phenyl}ethylamine (Method H) A mixture of 1-(4'-aminophenyl)-3,5-bis(trifluoromethyl)pyrazole (0.15 g, 0.58 mmol), ethyl iodide (0.10 mL, 1.26 mmol), and Hunig's base (0.20 mL, 1.14 mmol) in N,N-dimethylformamide (10 mL) was heated to 50 C. under argon with stirring. After 24 hours the mixture was diluted with water, and extracted with ethyl acetate. The organic phase was washed with water (4*25 mL), brine, dried (magnesium sulfate) and concentrated. The residue was purified by flash chromatography (ethyl acetate/hexanes) followed by recrystallization from ethanol/water to give the above-named compound (0.045 g) as yellow crystals. mp 54 C. NMR (CDCl3, 400 MHz): delta 7.26 (d, 2H), 7.02 (s, 1H), 6.64 (d, 2H), 3.93 (br s, 1H), 3.22 (q, 2H), 1.31 (t, 3H). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
78% | With sodium cyanoborohydride; acetic acid; In methanol; dichloromethane; acetone; | Example 11 Synthesis of N-{4-[3,5-bis(Trifluoromethyl)pyrazol-1-yl]phenyl}pyridin-4-ylmethylamine (Method I) A mixture of 1-(4'-aminophenyl)-3,5-bis(trifluoromethyl)pyrazole (0.059 g, 0.2 mmol) and pyridine-4-carboxaldehyde (20 muL, 0.2 mmol) in methanol (0.8 mL) and acetic acid (0.2 mL) was stirred at room temperature for 15 minutes Sodium cyanoborohydride (0.032 g, 0.5 mmol) was added, and the reaction mixture stirred overnight. The reaction mixture was diluted with CH2Cl2 (50 mL), washed with brine (2*20 mL), dried over anhydrous Na2SO4 and evaporated. The residue was purified by flash column chromatography over silica gel (2% acetone in CH2Cl2) to give the above-named compound (0.060 g, 78%): mp 92-94 C. NMR (DMSO-d6) delta 4.40 (2H, d), 6.65 (2H, d), 6.97 (1H, t), 7.23 (2H, d), 7.35 (2H, d), 6.65 (2H, d), 7.7 (1H, s), 8.51 (2H, d). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With 2-(Dimethylamino)pyridine; 1,2-dichloro-ethane; In dichloromethane; | Example 1 Synthesis of N-{4-[3,5-bis(Trifluoromethyl)pyrazol-1-yl]phenyl}cyclohexanecarboxamide (Method A). A mixture of cyclohexanecarboxylic acid (0.10 g, 0.8 mmol) and EDC (0.077 g, 0.4 mmol) in CH2Cl2 (1.5 mL) was stirred for 15 minutes. <strong>[123066-64-8]1(4'-Aminophenyl)-3,5-bis(trifluoromethyl)pyrazole</strong> (0.059 g, 0.2 mmol) was added followed by dimethylaminopyridine (0.01 g, 0.1 mmol). After 3 hours the mixture was diluted with CH2Cl2 (50 mL), washed with 10% NaHCO3 (2*50 mL), brine (3*25mL), and dried over anhydrous Na2SO4. Evaporation of the solvent gave the above-named compound as a solid that crystallized from benzene (0.075 g, 92%): mp 178-180 C.; 1H NMR (CDCl3) delta 1.35 (3H, m), 1.66 (2H, m), 1.75 (1H, m), 1.85 (2H, m), 2.0 (2H, m), 2.3 (1H, m), 7.08 (1H, s), 7.45 (1H, d, J=8.5 Hz), 7.75 (2H, d, J=8.5 Hz). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In dichloromethane; toluene; | Example 6 Synthesis of N-{4-[(3,5-bis(Trifluoromethyl)pyrazol-1-yl]phenyl}-N'-cyclohexylurea (Method E) To morpholinomethyl polystyrene (Novabiochem, substitution=3.55 mmol/g, 1.02 g, 3.62 mmol) in methylene chloride (18.5 mL) under argon was added 1-(4'-aminophenyl)-3,5-bis(trifluoromethyl)pyrazole (0.555 g, 1.88 mmol). The mixture was cooled to 0 C. and phosgene (1.93M in toluene, Fluka, 1.95 mL, 3.76 mmol) was added. After thirty minutes the reaction mixture was filtered, washed with methylene chloride (2*30 mL) and concentrated to give 1-(4'-isocyanatophenyl)-3,5-bis(trifluoromethyl)pyrazole. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In tetrahydrofuran; | Example 5 Synthesis of Benzo[d]isoxazol-3-yl-{4-[3,5-bis(trifluoromethyl)pyrazol-1-yl]phenyl}amine (Method D) To a stirred solution of 1-(4'-aminophenyl)-3,5-bis(trifluoromethyl)pyrazole (0.20 g, 0.68 mmol) and 3-chlorobenzisoxazole (0.10 g, 0.65 mmol) in tetrahydrofuran (2.5 mL) under argon was added sodium bis-trimethylsilyl amide (1.0 M in tetrahydrofuran, 0.68 mL, 0.68 mmol). After seven days, the mixture was diluted with water, and extracted with ethyl acetate. The organic layer was washed with brine, dried (magnesium sulfate) and concentrated. The residue was purified by flash chromatography (elution with ethyl acetate/hexanes) to give the above-named compound (0.050 g). m.p. 209-210 C. NMR (CDCl3, 400 MHz): delta 7.77 (d, 1H), 7.64 (m, 3H), 7.53 (d, 2H), 7.37 (m, 1H), 7.09 (s, 1H), 6.68 (s, 1H). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With triethylamine; In dichloromethane; | Example 2 Synthesis of N-{4-[3,5-bis(Trifluoromethyl)pyrazol-1-yl]phenyl}-2-methylbenzamide (Method B). A mixture of 1-(4'-aminophenyl)-3,5-bis(trifluoromethyl)pyrazole (0.10 g, 0.34 mmol), o-toluoyl chloride (0.062 mL, 0.43 mmol), and triethylamine (0.06 mL, 0.43 mmol) in methylene chloride (7 mL) was stirred under argon for three days. The reaction mixture was diluted with methylene chloride, washed with 1N hydrochloric acid (2*50 mL), brine (2*40 mL), dried (magnesium sulfate) and concentrated to give an off-white solid. Recrystallization from methylene chloride/hexanes gave the above-named compound (0.065 g). m.p. 175 C. NMR (CDCl3, 400 MHz): delta 7.83 (d, 2H), 7.64 (br s, 1H), 7.53 (m, 3H), 7.43 (m, 1H), 7.31 (m, 2H), 7.10 (s, 1H), 2.56 (s, 3H). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With benzaldehyde; toluene-4-sulfonic acid; In toluene; | Example 12 Synthesis of {4-[3,5-bis(Trifluoromethyl)pyrazol-1-yl]phenyl}-(1-phenylethyl)amine (Method J) A mixture of 1-(4'-aminophenyl)-3,5-bis(trifluoromethyl)pyrazole (1.5 g), benzaldehyde (0.53 g) and tosic acid (0.03 g) in toluene (20 mL) was heated under a Dean Stark apparatus at 140 C. for 3 hours. The mixture was filtered and evaporated to dryness to give N-(benzylidene)-1-(4'-aminophenyl)-3,5-bis(trifluoromethyl)pyrazole as a solid (1.4 g) which was used without further purification. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In 1,4-dioxane; ethanol; dichloromethane; | Example 4 Synthesis of 1-{4-[N-(4-Cyanopyridin-2-yl)amino]phenyl}-3,5-bis(trifluoromethyl)pyrazole (Method D) A mixture of 1-(4'-aminophenyl)-3,5-bis(trifluoromethyl)pyrazole (0.36 g) and 2-chloro-4-cyanopyridine (0.14 g) in dioxane (1 mL) was heated at 125 C. in a sealed tube for 5 days. The mixture was diluted with ethyl acetate and washed with water. The organic phase was dried, filtered and evaporated. Chromatography of the residue over silica gel (methylene chloride to 2% ethanol/methylene chloride gradient gave the above-named compound (0.22 g) mp 152-153 C. NMR (CDCl3) 8.45 (1H, m), 7.86 (3H, m), 7.48 (2H, d), 7.20 (1H, br s), 7.07 (1H, s), 6.91 (1H, m). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Example 1 Oxalyl chloride (8.7 ml) was added to a mixture of <strong>[22047-86-5]4,6-dimethylnicotinic acid</strong> (15.1 g) and dichloromethane (150 ml) under ice cooling, followed by stirring at 15 to 20C for one hour. A mixture of 4-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]aniline (23.59 g) and dichloromethane (300 ml) was added to the resulting reaction solution, followed by stirring at room temperature for 18 hours. An aqueous 20% potassium carbonate solution (about 200 ml) was added to the reaction solution, from which the organic layer was separated. Subsequently, the aqueous layer was extracted with dichloromethane (about 50 ml). The organic layer and the extract solution were combined together and subsequently concentrated under reduced pressure. The resulting residue was recrystallized from a mixed solvent (270 ml) of ethanol and water (2:1, respectively), to obtain 4,6-dimethyl-4'-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]nicotinanilide (26.70 g) as bluish white solid. FAB-MS(Pos.): m/z 429[(M+H)+]; NMR(DMSO-d6) delta: 2.41 (3H, s), 2.49(3H, s), 7.24(1H, s), 7.60(2h, d, J=8.8Hz), 7.79 (1H, s), 7.95 (2H, d, J=8.8Hz), 8.58 (1H, s), 10.72 (1H, s). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
59.7% | With dmap; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20℃; | To a solution of <strong>[123066-64-8]4-[3,5-bis(trifluoromethyl)pyrazolyl]phenylamine</strong> (89 mg, 0.3 mmol) in 5 ml DCM was added 2,6-difluorobenzoyl chloride (75 ??, 0.6 mmol) followed by addition of DIE A (174 ??) and DMAP (2 mg). The resulting solution was stirred overnight at room temperature. The reaction mixture was worked up with aq. NaHCOs/DCM. DCM phase was washed with brine, concentrated to dryness. The residue was dissolved in 3 mL THF/MeOH/H20 (5 :4: 1) and stirred with IN NaOH (600 ??) at room temperature for lh before worked up with EA/ aq. NaHCOs. Silica gel flash chromatography furnished (2,6-difiuorophenyl)-N-{4-[3,5- bis(trifluoromethyl)pyrazolyl]phenyl}carboxyamide 50 (78 mg, yield: 59.7%>, purity >95%>) as a white solid. MS (ESI) [M+H]+ 436.0. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
85% | To a solution of 4-(3,5-bis(trifluoromethyl)-lH-pyrazol-l-yl)aniline (4.16 g, 14.10 mmol) in water (62.7 mL) HC1 37% (5 mL) is added and the resulting mixture is cooled down at 0C. Then, a solution of NaN02 (0.97 g, 14.10 mmol) in water (6 mL) is added and after 10 minutes a solution of NaN3 (1.09 g, 16.9 mmol) in water (6 mL) is slowly added. The reaction is stirred at room temperature for additional 1 hour, diluted with EtOAc and washed with water (x 2). The organic layer is dried over sodium sulfate and the volatile is removed under vacuum. The crude material is purified by column chromatography using petroleum ether/ethyl acetate 95:5 as eluent, yielding compound 14 as a pale red oil (3.84 g, 11.96 mmol, 85%). Analytical data: 1H-NMR (300 MHz, CDC13): delta 7.47 (d, J 8.5 Hz, 2H), 7.14 (d, J 8.5 Hz, 2H), 7.0 (s, 1H). MS: M+l 322 |
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P301 + P330 + P331 | IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. |
P302 + P334 | IF ON SKIN: Immerse in cool water/wrap in wet bandages. |
P302 + P350 | IF ON SKIN: Gently wash with plenty of soap and water. |
P303 + P361 + P353 | IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
P304 + P312 | IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. |
P304 + P340 | IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. |
P304 + P341 | IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P305 + P351 + P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
P306 + P360 | IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. |
P307 + P311 | IF exposed: call a POISON CENTER or doctor/physician. |
P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
Sorry,this product has been discontinued.
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