Home Cart Sign in  
Chemical Structure| 123066-64-8 Chemical Structure| 123066-64-8
Chemical Structure| 123066-64-8

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

CRAC intermediate 2 is a chemical intermediate related to calcium release-activated calcium (CRAC) channels, playing a key role in calcium signaling in immune cells and regulating immune responses and T cell activation.

Synonyms: CRAC intermediate 2

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of CRAC intermediate 2

CAS No. :123066-64-8
Formula : C11H7F6N3
M.W : 295.18
SMILES Code : FC(C1=N[N](C(=C1)C(F)(F)F)C2=CC=C(C=C2)N)(F)F
Synonyms :
CRAC intermediate 2
MDL No. :MFCD00220969
InChI Key :XOXBUERZFCPKDR-UHFFFAOYSA-N
Pubchem ID :2740668

Safety of CRAC intermediate 2

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H332-H335
Precautionary Statements:P261-P280-P305+P351+P338

Application In Synthesis of CRAC intermediate 2

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 123066-64-8 ]

[ 123066-64-8 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 123066-64-8 ]
  • [ 2991-28-8 ]
  • N-[4-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]-2,5-difluorobenzamide [ No CAS ]
  • 2
  • [ 20485-41-0 ]
  • [ 123066-64-8 ]
  • 4-methyl-4'-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]thiazole-5-carboxyanilide [ No CAS ]
YieldReaction ConditionsOperation in experiment
With 1-ethyl-3-(3-dimethylamino-propyl)-carbodiimide hydrochloride; In 1,2-dichloro-ethane; at 20℃; A mixture of <strong>[20485-41-0]4-methylthiazole-5-carboxylic acid</strong> (108 mg), 4-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]aniline (223 mg), WSCD hydrochloride 152 mg) and DCE (5 ml) was stirred overnight at room temperature. Water (10 ml) was added to the reaction mixture, and the thus formed product was extracted with a mixed solvent of diethyl ether (5 ml) and ethyl acetate (10 ml). The extract was washed with 1 N hydrochloric acid, saturated sodium hydrogencarbonate aqueous solution and saturated brine in that order. The resulting organic layer was dried over anhydrous magnesium sulfate and then concentrated under a reduced pressure. The thus obtained residue was purified by silica gel column chromatography (eluent; n-hexane:ethyl acetate=3:1-2:1) and then recrystallized from a mixed solvent of ethyl acetate and n-hexane to give 4-methyl-4'-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]thiazole-5-carboxyanilide (143 mg) as colorless needles.
  • 3
  • [ 14190-59-1 ]
  • [ 123066-64-8 ]
  • 4'-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]thiazole-2-carboxanilide [ No CAS ]
 

Historical Records

Categories