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Chemical Structure| 1231892-74-2 Chemical Structure| 1231892-74-2

Structure of 1231892-74-2

Chemical Structure| 1231892-74-2

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Product Details of [ 1231892-74-2 ]

CAS No. :1231892-74-2
Formula : C15H20BNO3
M.W : 273.14
SMILES Code : O=C1NCCC2=C1C=C(B3OC(C)(C)C(C)(C)O3)C=C2
MDL No. :MFCD18383610
InChI Key :MGSHRQWUXRGGQS-UHFFFAOYSA-N
Pubchem ID :67261183

Safety of [ 1231892-74-2 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 1231892-74-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1231892-74-2 ]

[ 1231892-74-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 22245-95-0 ]
  • [ 73183-34-3 ]
  • [ 1231892-74-2 ]
YieldReaction ConditionsOperation in experiment
With tris-(dibenzylideneacetone)dipalladium(0); potassium acetate; XPhos; In 1,4-dioxane; at 80℃; for 18h;Inert atmosphere; Preparation 116: 7-(4,4,5,5-Tetramethyl-1 ,3,2-dioxaborolan-2-yl)-1 ,2,3,4-tetrahydro- isoquinolin-1-one (1708) A stirred mixture of 7-chloro-1 ,2,3,4-tetrahydroisoquinolin-1-one (500 mg, 2.75 mmol) bis(pinacolato)diboron (839 mg, 3.30 mmol), 2-dicyclohexylphosphino-2',4',6'- triisopropylbiphenyl (135 mg, 0.28 mmol) and AcOK (811 mg, 8.26 mmol) in anhydrous 1 ,4- dioxane (18 mL) was degassed with nitrogen for 10 minutes. Tris(dibenzylidene- acetone)dipalladium (0) (63 mg, 0.07 mmol) was then added and degassing continued for another 10 minutes. The mixture was heated at 80C under nitrogen for a total of 18 hours. After cooling to room temperature the mixture was diluted with water and extracted with EtOAc (x3). The combined organic layers were washed with brine, dried over MgSO, filtered and concentrated under vacuum to yield crude 7-(4,4,5,5-tetramethyl-1 ,3,2-dioxaborolan-2-yl)- 1 ,2,3,4-tetrahydroisoquinolin-1-one (0.8 g, 107 %) which was used as is. MS: [M+H]+ = 274.
 

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