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Chemical Structure| 1233184-54-7 Chemical Structure| 1233184-54-7

Structure of 1233184-54-7

Chemical Structure| 1233184-54-7

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Product Details of [ 1233184-54-7 ]

CAS No. :1233184-54-7
Formula : C7H6BrN3OS
M.W : 260.11
SMILES Code : O=S(C(N=C1)=NN2C1=CC=C2Br)C

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Application In Synthesis of [ 1233184-54-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1233184-54-7 ]

[ 1233184-54-7 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 52023-68-4 ]
  • [ 1233184-54-7 ]
  • [ 1232815-87-0 ]
YieldReaction ConditionsOperation in experiment
51% In 1-methyl-pyrrolidin-2-one; at 150℃; for 8h; Into a 3OmL vial, 7-Bromo-2-methanesulfmyl-pyrrolo[2,l-f][l,2,4]triazine (0.858 g, 0.00330 mol), [B] 6-Morpholin-4-yl-pyridin-3-ylamine (1.300 g, 0.007254 mol) and N- Methylpyrrolidinone (2.00 mL, 0.0207 mol) were added and heated at 150 0C for 8 hours. The solvent was removed under vacuum. The desired product was isolated via ISCO column chromatograpy with DCM and methanol as eluant (0 to 7% methanol). The collected fractions afforded (7-Bromo-pyrrolo[2,l-f][l,2,4]triazin-2-yl)-(6-morpholin-4- yl-pyridin-3- yl)-amine as a yellow solid(0.636g, 51%). NMR 1H (DSMOd6)- 9.47 (s,IH), 8.87 (s, IH), 8.74 (d, IH, J= 2.24 Hz), 8.00 (dd, IH, JJ= 2.20, 6.81 Hz), 6.93 (d, IH, J= 4.65 Hz), 6.82-6.90 (m,2H), 3.71 (t, 4H, J= 4.32 Hz), 3.36 (t, 4H, J= 4.57 Hz)
 

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