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[ CAS No. 123374-28-7 ] {[proInfo.proName]}

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Chemical Structure| 123374-28-7
Chemical Structure| 123374-28-7
Structure of 123374-28-7 * Storage: {[proInfo.prStorage]}
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Product Details of [ 123374-28-7 ]

CAS No. :123374-28-7 MDL No. :MFCD01570118
Formula : C9H14N2O2 Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 182.22 Pubchem ID :-
Synonyms :

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Application In Synthesis of [ 123374-28-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 123374-28-7 ]

[ 123374-28-7 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 123374-28-7 ]
  • [ 52334-81-3 ]
  • ethyl 3-propyl-1-[5-(trifluoromethyl)-2-pyridyl]-1H-pyrazole-4-carboxylate [ No CAS ]
YieldReaction ConditionsOperation in experiment
85% With potassium carbonate In DMF (N,N-dimethyl-formamide) at 100℃; Reference Example 31 Reference Example 31 A mixture of ethyl3-propyl-lH-pyrazole-4-carboxylate (25.88 g),2-chloro-5- (trifluoromethyl) pyridine(25. 14 g), potassium carbonate (34.11 g) and N, N-dimethylformamide (300 ml) was stirred overnight at100 C. The reaction mixture was poured into dilute hydrochloric acid, and extracted with ethyl acetate. The ethyl acetate layer was washed with saturated aqueous sodium chloride solution, dried(MgS04) and concentrated. The residue was subjected to silica gel column chromatography, and ethyl3-propyl-l- [5- (trifluoromethyl)-2-pyridyl]-lH-pyrazole-4-carboxylate (38.45 g, yield85%) was obtained as colorless crystals from a fraction eluted with ethyl acetate-hexane (1: 4, volume ratio). The crystals were recrystallized from isopropyl ether-hexane. melting point:102-103 C. 1H-NMR (CDC13) USD : 1.03 (3H, t, J=7.2 Hz), 1.38 (3H, t, J=7.0 Hz), 1.66-1. 88 (2H, m), 2.86-3. 00 (2H, m), 4.33 (2H, q, J=7.0 Hz), 7.99-8. 16 (2H, m), 8.65-8. 72 (1H, m), 8.99 (1H, s).
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