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CAS No. : | 123374-28-7 | MDL No. : | MFCD01570118 |
Formula : | C9H14N2O2 | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | - |
M.W : | 182.22 | Pubchem ID : | - |
Synonyms : |
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Signal Word: | Class: | ||
Precautionary Statements: | UN#: | ||
Hazard Statements: | Packing Group: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
85% | With potassium carbonate In DMF (N,N-dimethyl-formamide) at 100℃; | Reference Example 31 Reference Example 31 A mixture of ethyl3-propyl-lH-pyrazole-4-carboxylate (25.88 g),2-chloro-5- (trifluoromethyl) pyridine(25. 14 g), potassium carbonate (34.11 g) and N, N-dimethylformamide (300 ml) was stirred overnight at100 C. The reaction mixture was poured into dilute hydrochloric acid, and extracted with ethyl acetate. The ethyl acetate layer was washed with saturated aqueous sodium chloride solution, dried(MgS04) and concentrated. The residue was subjected to silica gel column chromatography, and ethyl3-propyl-l- [5- (trifluoromethyl)-2-pyridyl]-lH-pyrazole-4-carboxylate (38.45 g, yield85%) was obtained as colorless crystals from a fraction eluted with ethyl acetate-hexane (1: 4, volume ratio). The crystals were recrystallized from isopropyl ether-hexane. melting point:102-103 C. 1H-NMR (CDC13) USD : 1.03 (3H, t, J=7.2 Hz), 1.38 (3H, t, J=7.0 Hz), 1.66-1. 88 (2H, m), 2.86-3. 00 (2H, m), 4.33 (2H, q, J=7.0 Hz), 7.99-8. 16 (2H, m), 8.65-8. 72 (1H, m), 8.99 (1H, s). |