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Chemical Structure| 1235491-93-6 Chemical Structure| 1235491-93-6

Structure of 1235491-93-6

Chemical Structure| 1235491-93-6

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Product Details of [ 1235491-93-6 ]

CAS No. :1235491-93-6
Formula : C10H10ClN3O
M.W : 223.66
SMILES Code : NC1=CC=C(N2C=C(Cl)N=C2)C(OC)=C1

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Application In Synthesis of [ 1235491-93-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1235491-93-6 ]

[ 1235491-93-6 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 1235491-93-6 ]
  • [ 161622-05-5 ]
  • [ 1555543-66-2 ]
YieldReaction ConditionsOperation in experiment
80% General procedure: A mixture of phenyl acid (0.001mol), EDCl (0.003mol), HOBt (0.002mol), Triethylamine (0.006mol) and dichloromethane (5.0mL) was stirred vigorously for 10min at ambient temperature. Then amine (5) (0.0022mol) in dichloromethane was added slowly to the reaction mixture. The reaction mass was stirred at ambient temperature for 4h. The reaction completion was monitored by TLC. After completion, the reaction mass was diluted with dichloromethane, washed with 10% NaHCO3 (10mL), brine solution. The organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure. The crude product was purified on a Biotage parallel column purifier using ethyl acetate: petroleum ether (3:1) as eluant to methanol: methylene chloride (2-6%). The spectral data of compounds 6(a-o) are given below.
  • 2
  • [ 1235491-93-6 ]
  • [ 123843-65-2 ]
  • [ 1555543-76-4 ]
YieldReaction ConditionsOperation in experiment
62% General procedure: A mixture of phenyl acid (0.001mol), EDCl (0.003mol), HOBt (0.002mol), Triethylamine (0.006mol) and dichloromethane (5.0mL) was stirred vigorously for 10min at ambient temperature. Then amine (5) (0.0022mol) in dichloromethane was added slowly to the reaction mixture. The reaction mass was stirred at ambient temperature for 4h. The reaction completion was monitored by TLC. After completion, the reaction mass was diluted with dichloromethane, washed with 10% NaHCO3 (10mL), brine solution. The organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure. The crude product was purified on a Biotage parallel column purifier using ethyl acetate: petroleum ether (3:1) as eluant to methanol: methylene chloride (2-6%). The spectral data of compounds 6(a-o) are given below.
 

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