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Chemical Structure| 123572-64-5 Chemical Structure| 123572-64-5

Structure of 123572-64-5

Chemical Structure| 123572-64-5

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Product Details of [ 123572-64-5 ]

CAS No. :123572-64-5
Formula : C7H3F4NO3
M.W : 225.10
SMILES Code : FC(F)(F)OC1=CC=C([N+]([O-])=O)C(F)=C1
MDL No. :MFCD13194450

Safety of [ 123572-64-5 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H317-H319
Precautionary Statements:P280-P305+P351+P338

Application In Synthesis of [ 123572-64-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 123572-64-5 ]

[ 123572-64-5 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 1077-01-6 ]
  • [ 123572-65-6 ]
  • [ 123572-64-5 ]
YieldReaction ConditionsOperation in experiment
With sulfuric acid; nitric acid; at 0 - 20℃; 11A) 4-Fluoro-1-nitro-2-trifluoromethoxy-benzene To 1-fluoro-3-trifluoromethoxybenzene (1 mL) was added concentrated sulfuric acid (1 mL) at 0 C. To the cold solution was added dropwise (0.7 mL) of a solution made from concentrated nitric acid (1 mL) and concentrated sulfuric acid (1 mL). The reaction was slowly allowed to warm to room temperature then poured onto ice and extracted with ether. The organic layer was separated and washed with sodium hydroxide 1N, then brined and dried over magnesium sulfate. The solvent was removed under reduce pressure at room temperature. A pale yellow oil (1 g) was recovered and used without further purification.
  • 2
  • [ 1077-01-6 ]
  • [ 123572-64-5 ]
YieldReaction ConditionsOperation in experiment
With sulfuric acid; potassium nitrate; at 0℃; for 1h; To a solution of <strong>[1077-01-6]1-fluoro-3-(trifluoromethoxy)benzene</strong> (2.Og, 11.lmmol) in H2504 (5.OmL) was added KNO3 (1.34g, 13.3mmol) at 0C. The reaction mixture was stirred at 0 O for 1 h. TLC showed the reaction to be complete. The reaction mixture was diluted with H20 (5OmL) and extracted with EtOAc (3x50m1). The organic layer was dried over Na2504 and concentrated under reduced pressure. The residue was triturated with 10% EtOAc in hexane to afford 2-fluoro-1-nitro-4- (trifluoromethoxy)benzene as a yellow liquid. Yield: 1.8g (crude). The crude data showed product and it was used in the next step without further purification.
 

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