Alternatived Products of [ 123572-64-5 ]
Product Details of [ 123572-64-5 ]
| CAS No. : | 123572-64-5 |
MDL No. : | MFCD13194450 |
| Formula : |
C7H3F4NO3
|
Boiling Point : |
- |
| Linear Structure Formula : | - |
InChI Key : | - |
| M.W : |
225.10
|
Pubchem ID : | - |
| Synonyms : |
|
Safety of [ 123572-64-5 ]
| Signal Word: | Warning |
Class: | N/A |
| Precautionary Statements: | P280-P305+P351+P338 |
UN#: | N/A |
| Hazard Statements: | H317-H319 |
Packing Group: | N/A |
| GHS Pictogram: |
|
Application In Synthesis of [ 123572-64-5 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 123572-64-5 ]
- 1
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[ 822-36-6 ]
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[ 123572-65-6 ]
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[ 123572-64-5 ]
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4-Methyl-1-(4-nitro-3-trifluoromethoxy-phenyl)-1H-imidazole
[ No CAS ]
-
[ 1159795-41-1 ]
| Yield | Reaction Conditions | Operation in experiment |
|
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 16h; |
104.A.2 13A)
13A) 4-Methyl-1-(4-nitro-3-trifluoromethoxy-phenyl)-1H-imidazole The crude product from step 1, Method A, (1 g, 4.4 mmol) was dissolved in DMF (8 mL). To this was added 4-methyl imidazole (0.36 g, 0.44 mmol) followed by potassium carbonate (1.2 g, 0.88 mmol). The reaction was let stir at room temperature for 16 hrs then poured into water and extracted with ethyl acetate. The organic layer was separated and washed with water then brined, dried over magnesium sulfate and filtered. The solvent was removed under reduced pressure and the cruder purified by flash chromatography on silica gel in ethyl acetate. A yellow solid (0.3 g) was recovered as intermediate 12A, Method A. MS (ES) m/z 288.0 [M+1]+ |
- 2
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[ 1077-01-6 ]
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[ 123572-65-6 ]
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[ 123572-64-5 ]
| Yield | Reaction Conditions | Operation in experiment |
|
With sulfuric acid; nitric acid; at 0 - 20℃; |
11A) 4-Fluoro-1-nitro-2-trifluoromethoxy-benzene To 1-fluoro-3-trifluoromethoxybenzene (1 mL) was added concentrated sulfuric acid (1 mL) at 0 C. To the cold solution was added dropwise (0.7 mL) of a solution made from concentrated nitric acid (1 mL) and concentrated sulfuric acid (1 mL). The reaction was slowly allowed to warm to room temperature then poured onto ice and extracted with ether. The organic layer was separated and washed with sodium hydroxide 1N, then brined and dried over magnesium sulfate. The solvent was removed under reduce pressure at room temperature. A pale yellow oil (1 g) was recovered and used without further purification. |
- 3
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[ 1077-01-6 ]
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[ 123572-64-5 ]
| Yield | Reaction Conditions | Operation in experiment |
|
With sulfuric acid; potassium nitrate; at 0℃; for 1h; |
To a solution of <strong>[1077-01-6]1-fluoro-3-(trifluoromethoxy)benzene</strong> (2.Og, 11.lmmol) in H2504 (5.OmL) was added KNO3 (1.34g, 13.3mmol) at 0C. The reaction mixture was stirred at 0 O for 1 h. TLC showed the reaction to be complete. The reaction mixture was diluted with H20 (5OmL) and extracted with EtOAc (3x50m1). The organic layer was dried over Na2504 and concentrated under reduced pressure. The residue was triturated with 10% EtOAc in hexane to afford 2-fluoro-1-nitro-4- (trifluoromethoxy)benzene as a yellow liquid. Yield: 1.8g (crude). The crude data showed product and it was used in the next step without further purification. |
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