There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type | HazMat fee for 500 gram (Estimated) |
Excepted Quantity | USD 0.00 |
Limited Quantity | USD 15-60 |
Inaccessible (Haz class 6.1), Domestic | USD 80+ |
Inaccessible (Haz class 6.1), International | USD 150+ |
Accessible (Haz class 3, 4, 5 or 8), Domestic | USD 100+ |
Accessible (Haz class 3, 4, 5 or 8), International | USD 200+ |
Purity | Size | Price | VIP Price | USA Stock *0-1 Day | Global Stock *5-7 Days | Quantity | |||||
{[ item.p_purity ]} | {[ item.pr_size ]} |
{[ getRatePrice(item.pr_usd, 1,1) ]} {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]} |
{[ getRatePrice(item.pr_usd, 1,1) ]} | Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_usd,1,item.mem_rate) ]} | {[ item.pr_usastock ]} | Inquiry - | {[ item.pr_chinastock ]} | Inquiry - |
* Storage: {[proInfo.prStorage]}
CAS No. : | 1239-45-8 | MDL No. : | MFCD00011724 |
Formula : | C21H20BrN3 | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | ZMMJGEGLRURXTF-UHFFFAOYSA-N |
M.W : | 394.31 | Pubchem ID : | 14710 |
Synonyms : |
EtBr;Homidium bromide
|
Signal Word: | Danger | Class: | 6.1 |
Precautionary Statements: | P201-P202-P260-P264-P270-P271-P280-P284-P301+P312+P330-P304+P340+P310-P308+P313-P403+P233-P405-P501 | UN#: | 2811 |
Hazard Statements: | H302-H330-H341 | Packing Group: | Ⅰ |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With nitrobenzene Erhitzen des Reaktionsprodukts mit wss. H2SO4 und anschliessendes Behandeln mit wss. NH3 und NH4Br; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In water; acetonitrile |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In methanol; water; acetonitrile for 48h; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
1: 0.5% 2: 70% | With dmap; dicyclohexyl-carbodiimide In N,N-dimethyl-formamide at 0℃; for 24h; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In water; acetonitrile |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
30% | In water for 8h; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With hydrogenchloride; hypophosphorous acid; sodium nitrite 1) 0 deg C, 2) water, overnight; Yield given. Multistep reaction; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
24% | With hydrogenchloride; hypophosphorous acid; sodium nitrite In water at 0℃; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Yield given. Multistep reaction; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With hydrogenchloride; sodium azide; sodium nitrite 1) water, 0 deg C, 3 min 2) water, 0 deg C, overnight; Yield given. Multistep reaction; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
72% | Stage #1: ethidium Bromide With hydrogenchloride; sodium nitrite In water for 0.166667h; Stage #2: With sodium azide In water | |
With hydrogenchloride; sodium azide; sodium nitrite 1) water, 0 deg C, lO min 2) water, 1 h; Yield given. Multistep reaction; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With hydrogenchloride; sodium nitrite at 0℃; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With sodium tetrahydroborate In methanol at 0℃; for 24h; | ||
With sodium tetrahydroborate In methanol at 0℃; for 24h; | ||
With methanol; sodium tetrahydroborate at 0℃; for 20h; Inert atmosphere; Darkness; | Synthesis of Hydroethidium Hydroethidium (HE) was prepared as follows: 54 mg of NaBH4 was added into 100 mg of EtBr, which was previously dissolved in 2 ml absolute methanol at 0 °C under nitrogen atmosphere in dark condition. After 20 h stirring, methanol was evaporated under vacuum and 3 ml of 3 v/v% NaOH solution was added. The precipitate was extracted several times with ether and washed with water. The precipitate was dried over anhydrous sodium sulfate and then recrystallized in ether to yield a light brown powder (Scheme 1). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
59% | With sulfuric acid at 150℃; for 0.333333h; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In water Ambient temperature; | ||
In water |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In N,N-dimethyl-formamide at 70℃; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
14% | Stage #1: ethidium Bromide With sodium nitrite In water at 0℃; for 0.05h; Stage #2: With sodium azide In water |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
90% | In water at 130℃; for 1h; | |
90% | at 130℃; for 1.25h; Heating / reflux; | 3,8-Bis-pyrole-ethidium OAc (22). Ethidium bromide/4% water (264 mg, 670 umoles) was dissolved in glacial acetic acid (10 mL) (by sonication) and brought to 130 °C. Two portions of dimethoxytetrahydrofuran (2x110 UL, 1.65 mmoles total, 2.5 equiv) were added 15 min apart. The reaction was kept under reflux (at 130 °C) for an additional lh and cooled to RT. All volatiles were then removed under reduced pressure, and the solid was dissolved in methanol (-40 mL) and filtered over a plug of silica gel (~30 mL). The gel was washed with methanol (-60 mL), and the methanolic fractions combined and concentrated to 280 mg (90%) of a yellow solid under reduced pressure. The product can be further purified using a reversed phase C-18 semi-prep column with a 50-80% acetonitrile/ water (0. 1% TFA) gradient over 20 MIN. 1H NMR (400 MHz, D6- acetone, 20 °C) : No. 9.38 (d, J = 9. 0 HZ, 1H), 5 9.32 (d, J = 9.0 Hz, 1H), 5 8. 73 (d, J = 2.1 HZ, 1H), 5 8. 64 (dd J7 = 9. 0 Hz, JZ = 2.4 Hz, 1H), No. 8. 49 (dd J7 = 9.0 Hz, J2 = 2.1 Hz, 1H), 7.91-8. 01 (m, 5H), 5 7.72 (dd, JI= Jz = 2.1 Hz, 2H), 5 7.54 (d, 2. 4 HZ, 1H), 5 7. 24 (dd, J7 = Jz = 2.1 HZ, 2H), 5 6. 46 (dd, J = J2 = 2.1 HZ, 2H), No. 6. 34 (dd, Jy = J2 = 2. 1 HZ, 2H), 5 5. 24 (q, J = 7. 2 Hz, 2H), No. 1.58 (t, J = 7.2 Hz, 3H). FAB MS calculated for C29H24N3 : 414.1970, found 414.1951 [M] + W-VIS (50 mM sodium phosphate pH 7.5) : AMAX (NM) and No. (cm-1M-1) : 302 (4.6 x 104)-428 (5.2 x103). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
1: 18% 2: 4% | Multistep reaction; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
1: 50% 2: 10% 3: 4% | Stage #1: ethidium Bromide; benzyl chloroformate In phosphate buffer; water; acetone at 40℃; for 0.333333h; Stage #2: With AG1-X4(Cl-) ion exchange resin In phosphate buffer; acetone at 40℃; for 0.0833333h; | |
1: 10% 2: 50% 3: 4% | Stage #1: ethidium Bromide; benzyl chloroformate With sodium phosphate In water; acetone at 32 - 40℃; for 0.333333h; Stage #2: In water; acetone | 3-Cbz-ethidium. Cl (2), 8-cbz-ethidium. Cl (3), and 3, 8-BIS-CBZ ethidium-Cl (4). Ethidium bromide/8% water (4.13 g, 9.64 mmoles) was dissolved in 0.2 M sodium phosphate pH 6.6 (100 ML), acetone (80 mL) and warmed to 32 °C. To this, a solution of benzyl chloroformate (1.43 mL, 10 mmoles, 1 equiv) in acetone (20 mL) was slowly added and the reaction warmed to 40 °C for 20 min. AGI-X4 (CL-) ion exchange resin (20 g, 70 mmoles, 7 mequiv) was then added and stirred 5 min, 40 °C. The slurry was loaded onto a column containing another 20 g (7 mequiv) of AGI-X4 (CL-) ion exchange resin and the eluent collected. The resin was washed with 30 mL of 1: 1 watedacetone, and the eluents were combined and reduced to a solid under reduced pressure. The products were separated on silica gel using three consecutive columns (8-10 MEOH/ CH2CL2, 5 - 12% MeOH / CH2Cl2, and 10% MEOH/CH2C12). The pure fractions from each column were combined to yield : 0.48 g of the orange-red solid, 3-CBZ-ETHIDIUM-CL (2) (10%). Rf = 0.5 (20% MEOH/CHC13). 1H NMR (400 MHz, d6-DMSO, 25 °C) : No. 10.61 (s, 1H), 5 8.92 (d, J=9. 2Hz, 1H), 5 8.76 (d, J=9. 2Hz, 1H), 8.67 (s, 1H), No. 7.97 (d, J = 9.2 Hz, 1H), No. 7.72-7. 79 (m, 5H), 7. 58 (dd J1 = 9. 2 Hz, J2 = 2.2 HZ, 1H), 5 7. 36-7. 48 (m, 5H), 5 6.38 (d, LUT 2.2 Hz, 1H), 5 6. 22 (s, 2H), No. 5.24 (s, 2H), 5 4.54 (q, J = 7.0 Hz, 2H), 5 1.45 (t, J = 7.0 Hz, 3H). ESI MS calculated for C29H26N302 : 448.2, found 448.3 [M] +. W-vis (50 mM sodium phosphate pH 7.5) : No.MAX (nm) and No. (CM-1 M-1) : 212 (4.11 X 104), 284 (5.6 X 104), 454 (4.9 x 103). 2.3 g of the purple solid, 8-cbz-ethidium Cl (3) (50%). Rf = 0.38 (20% MeOH/CHCl3). 1H NMR (400 MHz, d6-DMSO, 25 °C) : No. 10.31 (s, 1H), 6 8. 83 (d, J = 9.6 HZ, 1H), No. 8. 78 (d, J = 9. 2 Hz, IH), 5 8.1 1 (dd JF = 9.6 Hz, J2 = 1.6 Hz, 1H), No. 7.71-7. 77 (m, 5H), 5 7.64 (d, J = 1.6 Hz, 1H), 7.44 (s, IH), No. 7.36-7. 42 (m, 6H), 6.66 (s, 2H), 5.08 (s, 2H), 5 4. 49 (q, J = 7.2 Hz, 2H), 5 1.42 (t, J = 7.2 Hz, 3H). ESI MS calculated for C29H26N302 : 448.2, found 448.3 [M] +. W-VIS (50 mM sodium phosphate pH 7.5) : Amax (nm) and S (CM- M- 1) : 214 (3. 4x104), 286 (4.4 X 104), 460 (4.5 X 103). 0.23 g of the yellow solid, 3, 8-BIS-CBZ-ETHIDIUM-CL (4) (4%). Rf = 0.67 (20% MeOH/CHCl3). 1H NMR (400 MHz, D6-DMSO, 25 °C) : 6 10.76 (s, 1H), 5 10.45 (s, 1H), No. 8.85 (d, J = 9. 2 Hz, 1 H), 5 9.03 (d, J = 9.2 Hz, 1H), 5 8. 78 (S, 1H), No. 8. 28 (dd J1 = 9.2 Hz, J2 = 2.0 Hz, 1H), No. 8.10 (d, J = 9.2 Hz, 1H), 6 7. 74-7.81 (m, 6H), No. 7.33-7. 49 (m, 10H), 5 5.26 (s, 2H), 5.10 (s, 2H), No. 4.62 (q, J= 7. 0 Hz, 2H), No. 1. 49 (t, J = 7.2 Hz, 3H). ESI MS calculated for C37H32N304 : 582, found 582 [M] +. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
98% | With sodium phosphate In water; acetone at 20℃; for 0.166667h; | |
98% | With sodium phosphate In water; acetone at 20℃; for 0.166667h; | 3,8-BIS-PHENOXYCARBAMATE-ETHIDIUM H2PO4 (14). Ethidium bromide/8% water (1) (200 mg, 466 umoles), 500 mM sodium phosphate pH 6.6 (5 mL), and acetone (8 mL) were combined, and phenyl chloroformate (587 µL, 4.66 mmoles, 5 mequiv, pre-dissolved in 2.5 mL acetone) was added dropwise. After 10 min at RT the reaction was cooled to-80 °C and vacuum filtered. The precipitate was washed with 20% acetone/water (10 mL), 100% acetone (-80 °C, 10 mL), and dried under reduced pressure to yield 300 mg (98%) of a yellow SOLID. 1H NMR (400 MHz, d6-DMSO 20 °C) : 5 11.36 (s, 1H), 6 10.98 (s, IH), 5 9.17 (d, J = 9.2 Hz, 1H), No. 9.12 (d, J = 8.8 Hz, 1H), No. 8.87 (S, 1H), No. 8.36 (dd J = 9.2 Hz, JZ = 2.0 Hz, 1H), 5 8.22 (d, J = 9.2 Hz, 1H), No. 7.85 (d, J = 2.4 Hz, 1H), 6 7.77 (s, 5H), 5 7.38-7. 50 (m, 4H), No. 7.24-7. 43 (m, 4H), No. 7.15-7. 19 (m, 2H), 5 4.64 (9, J = 7.6 Hz, 2H), 1.48 (t, J = 7.2 Hz, 3H). ESI MS calculated for C36H30N3O4 : 554.2, found 554.3 [M] +. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In N,N-dimethyl-formamide at 75℃; for 24h; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
90% | In N,N-dimethyl-formamide at 75℃; for 24h; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 2 steps 1.1: 90 percent / dimethylformamide / 24 h / 75 °C 2.1: 1-hydroxybenzotriazole hydrate; N,N'-diisopropylethylamine; HBTU / 1-methyl-pyrrolidin-2-one / 0.5 h 2.2: NH4Cl / 1-methyl-pyrrolidin-2-one / 24 h |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 2 steps 1: 98 percent / aq. sodium phosphate / acetone; H2O / 0.17 h / 20 °C / pH 6.6 2: 99 percent / NH3 gas / methanol / 1 h / 80 °C |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 2 steps 1.1: 98 percent / aq. sodium phosphate / acetone; H2O / 0.17 h / 20 °C / pH 6.6 2.1: dimethylsulfoxide / 0.08 h / 90 °C 2.2: 100 percent / H2O; acetonitrile |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 2 steps 1.1: 98 percent / aq. sodium phosphate / acetone; H2O / 0.17 h / 20 °C / pH 6.6 2.1: 2,4,6-collidine / dimethylsulfoxide / 0.5 h / 85 °C 2.2: 91 percent / H2O; acetonitrile |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 2 steps 1.1: 98 percent / aq. sodium phosphate / acetone; H2O / 0.17 h / 20 °C / pH 6.6 2.1: 2,4,6-collidine / dimethylsulfoxide / 1 h / 90 °C 2.2: 31 percent / H2O; acetonitrile |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 2 steps 1.1: 98 percent / aq. sodium phosphate / acetone; H2O / 0.17 h / 20 °C / pH 6.6 2.1: Na2CO3 / dimethylsulfoxide / 0.75 h / 85 °C 2.2: 25 percent / H2O; acetonitrile |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 3 steps 1.1: H2O 2.1: NaNO2 / aq. HCl / 0.17 h 2.2: NaN3 / aq. HCl / 3 h / 0 °C 3.1: HCl / H2O / 2 h / 70 °C |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 2 steps 1.1: H2O 2.1: NaNO2 / aq. HCl / 0.17 h 2.2: NaN3 / aq. HCl / 3 h / 0 °C |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 2 steps 1: NaBH4 / methanol / 24 h / 0 °C 2: DCC / acetonitrile / 12 h / 0 °C |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 3 steps 1: NaBH4 / methanol / 24 h / 0 °C 2: DCC / acetonitrile / 12 h / 0 °C 3: I2, triethylamine / methanol / Heating |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 3 steps 1: 30 percent / H2O / 8 h 2: dimethylformamide 3: hydrazine / methanol / 8 h / Heating |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 2 steps 1: 30 percent / H2O / 8 h 2: dimethylformamide |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 4 steps
1: H2O / Ambient temperature
3: 1) Na |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 5 steps
1: H2O / Ambient temperature
3: 1) Na |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 2 steps 1: H2O / Ambient temperature |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 3 steps
1: H2O / Ambient temperature
3: 1) Na |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 2 steps 1: sodium borohydride / methanol / 24 h / 0 °C 2: DCC / acetonitrile / 20 h |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 3 steps 1: sodium borohydride / methanol / 24 h / 0 °C 2: DCC / acetonitrile / 20 h 3: 80 percent / I2, triethylamine / methanol / Heating |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 3 steps 1: NaNO2, HCl / 0 °C 2: 76 percent 3: 63 percent / Na2S / H2O; acetone |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 4 steps 1: NaNO2, HCl / 0 °C 2: 76 percent 3: 63 percent / Na2S / H2O; acetone 4: 74 percent |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 2 steps 1: NaNO2, HCl / 0 °C 2: 76 percent |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 2 steps 1: aq. HCl, 48percent hypophosphorous acid, sodium nitrite / H2O / 0 °C 2: 1) aq. HCl, sodium nitrite 2) sodium azide / 1) water, O deg C, 3 min. 2) water, overnight | ||
Multi-step reaction with 2 steps 2: 1) aq. HCl, sodium nitrite 2) sodium azide / 1) water, O deg C, 3 min. 2) water, overnight |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 2 steps 1: 24 percent / aq. HCl, 48percent hypophosphorous acid, sodium nitrite / H2O / 0 °C 2: 1) aq. HCl, sodium nitrite 2) water, sodium azide / 1) 0 deg C, 5 min. 2) water, overnight |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 6 steps 1: 92 percent / N,N-diethylaniline / ethanol / 0.17 h / Heating 2: 93 percent / iron, hydrochlorid acid / Heating; 1) water, 1 h, 2) aqueous ethanol, 20 min 3: 77 percent / nitrobenzene / Heating 4: 66 percent / POCl3 / 0.75 h / Heating 5: N,N-dimethyl-acetamide / 0.5 h 6: 59 percent / diluted H2SO4 / 0.33 h / 150 °C |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 4 steps 1: 77 percent / nitrobenzene / Heating 2: 66 percent / POCl3 / 0.75 h / Heating 3: N,N-dimethyl-acetamide / 0.5 h 4: 59 percent / diluted H2SO4 / 0.33 h / 150 °C |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 5 steps 1: 93 percent / iron, hydrochlorid acid / Heating; 1) water, 1 h, 2) aqueous ethanol, 20 min 2: 77 percent / nitrobenzene / Heating 3: 66 percent / POCl3 / 0.75 h / Heating 4: N,N-dimethyl-acetamide / 0.5 h 5: 59 percent / diluted H2SO4 / 0.33 h / 150 °C |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 3 steps 1: 66 percent / POCl3 / 0.75 h / Heating 2: N,N-dimethyl-acetamide / 0.5 h 3: 59 percent / diluted H2SO4 / 0.33 h / 150 °C |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 2 steps 1: N,N-dimethyl-acetamide / 0.5 h 2: 59 percent / diluted H2SO4 / 0.33 h / 150 °C |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 7 steps 1: 93 percent / 100percent sulfuric acid, potassium nitrate / 1 h / 15 - 20 °C 2: 92 percent / N,N-diethylaniline / ethanol / 0.17 h / Heating 3: 93 percent / iron, hydrochlorid acid / Heating; 1) water, 1 h, 2) aqueous ethanol, 20 min 4: 77 percent / nitrobenzene / Heating 5: 66 percent / POCl3 / 0.75 h / Heating 6: N,N-dimethyl-acetamide / 0.5 h 7: 59 percent / diluted H2SO4 / 0.33 h / 150 °C |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With 2,4,6-trimethyl-pyridine; mercury dichloride In DMF (N,N-dimethyl-formamide); water at 0 - 20℃; for 12h; | 3, 8-BIS-GUANIDINO-ETHIDIUM-3HC1 (9). Ethidium bromide/8% water (1) (30 mg, 70 umoles) was dissolved in DMF (3 mL), brought to 0 °C, and N, N'-bis-Boc-S-methyl-isothiourea (180 mg, 620 mmoles, 4.4 mequiv), mercury dichloride (282 mg, 1.04 mmoles, 7.4 mequiv) and 2,4, 6-collidine (220 UL, 1.67 mmoles, 12 mequiv) were added. The reaction was slowly warmed to RT, stirred for an additional 12 h, then diluted into 150 mL CHC13 and washed with 0.1 M citric acid (3X50 mL), 50 g/L of EDTA (40 mL), brine (40 mL) dried over sodium sulfate and concentrated to a solid under reduced pressure. Silica gel (40 mL) was used to purify the BOC-protected product (1. 5-5% MeOH/CHC13) to yield 40 mg of a yellow solid. The product was then deprotected by adding TFA (4 mL, containing 2.5 % (v/v) of triisopropylsilane) and mixing for 1 hr at RT, it was then diluted into 150 mL water and washed with diethyl ether (3X40 mL) and CHC13 (3X40 mL). The aqueous phase was concentrated to a solid, then dissolved in water (5 mL) and treated with AGI- X4 (CL-) ion exchange resin (1.5 g, 5.2 mmoles, 74 mequiv) for 5 min at RT. It was then filtered over an activated Water's "Sep-pack"C-18 reversed phase column (activated with 10 mL acetonitrile, 10 mL water), the remainder of the product eluted from the column using 20% acetonitrile/water and lyophilized to 25 mg of a yellow solid (76%). 1H NMR (300 MHz, D20, 25 °C) : 6 8. 90 (d, J = 9.0 Hz, 1H), 6 8. 83 (d, J = 9.3 Hz, 1H), 5 8. 22 (d, J = 1.8 HZ, IH), 6 7. 96 (dd J7 = 8.7 HZ, J2 = 2.1 Hz, 1H), 5 7. 84 (dd, J = 9.0 HZ, J2 = 1.8 Hz, 1H), 6 7. 57- 7.65 (m, 3H), No. 7.42-7. 46 (m, 2H), No. 7.32 (d, J = 2.4 Hz, 1H), No. 4.73 (4, J = 7.2 Hz, 2H), No. 1.39 (t, J = 7.2 Hz, 3H). ESI MS calculated for C23H24N7 : 398.2, found 398.3 [M] +. W-VIS (50 mM sodium phosphate pH 7.5) : XMAX (nm) and S (CM 1M-L) : 213 (3.6 x 104), 278 (5.4 x 104) ~ 398 (5.0 X 103). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Stage #1: 2-carboxy-ethyl-1-carboxamicacid-cortisol-21-ester With 4-methyl-morpholine; isobutyl chloroformate In tetrahydrofuran at -20℃; for 2h; Stage #2: ethidium Bromide In tetrahydrofuran at 20℃; for 24h; | 5.1 Example 5.1 20 mg 2-carboxy-ethyl-1-carboxamicacid-cortisol-21-ester dissolved in 1 ml THF are treated for 2 h at -20° C. with 9 μl isobutylchloroformate in presence of 15 μl NMM. After 2 h 17.4 mg ethidiumbromide are added and stirred for 24 h at 20° C. the mixture is then evaporated at 60° C. in a N2-flow. The desired product is purified by TLC (n-BuOH:HOAc:H2O=3:1:1 mixture; Rf=0.75); UV: 240 (ε=15000), 298 (ε=27800), 324 (ε=12000). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Stage #1: C45H71FN2O9 With 4-methyl-morpholine; isobutyl chloroformate In tetrahydrofuran at -20℃; for 2h; Stage #2: ethidium Bromide With 4-methyl-morpholine In tetrahydrofuran; DMF (N,N-dimethyl-formamide) at 20℃; for 72h; | 5.9 Example 5.9 10 mg compound of Formula 16 dissolved in 1 ml THF are treated for 2 h at -20° C. with 3.3 μl isobuthylchloroformate in presence of 4.19 μl NMM. After2 h a solution of 5 mg ethidiumbromide in 1 ml DMF and 4.19 μl NMM is added and stirred for 72 h at 20° C. The mixture is then evaporated at 6° C. in a N2-flow, washed in 5 ml MeOH and again evaporated at 60° C. The product is purified by TLC (EtOAc:MeOH:Aceton=3:1:3 mixture; Rf=0.14); UV: 240 (ε=14750), 298 (ε=27100), 324 (ε=11950). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
94% | With sodium borodeuteride In methanol for 0.333333h; Darkness; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
57% | Stage #1: 3,8-dinitro-5-ethyl-6-phenylphenanthridinium ethyl sulfate With sulfuric acid; iron In ethanol; water for 1.5h; Reflux; Stage #2: With ammonia In ethanol; water at 25℃; Further stages; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 6 steps 1.1: nitric acid / tetrachloromethane 2.1: hydrogen / ethanol / 60 °C / 22052.2 Torr 3.1: sulfuric acid; potassium nitrate 4.1: tin(IV) chloride / nitrobenzene 5.1: nitrobenzene / 17.5 h / 20 - 165 °C 6.1: sulfuric acid; iron / ethanol; water / 1.5 h / Reflux 6.2: 25 °C |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 5 steps 1.1: hydrogen / ethanol / 60 °C / 22052.2 Torr 2.1: sulfuric acid; potassium nitrate 3.1: tin(IV) chloride / nitrobenzene 4.1: nitrobenzene / 17.5 h / 20 - 165 °C 5.1: sulfuric acid; iron / ethanol; water / 1.5 h / Reflux 5.2: 25 °C |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 2 steps 1.1: nitrobenzene / 17.5 h / 20 - 165 °C 2.1: sulfuric acid; iron / ethanol; water / 1.5 h / Reflux 2.2: 25 °C |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 3 steps 1.1: tin(IV) chloride / nitrobenzene 2.1: nitrobenzene / 17.5 h / 20 - 165 °C 3.1: sulfuric acid; iron / ethanol; water / 1.5 h / Reflux 3.2: 25 °C |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 4 steps 1.1: sulfuric acid; potassium nitrate 2.1: tin(IV) chloride / nitrobenzene 3.1: nitrobenzene / 17.5 h / 20 - 165 °C 4.1: sulfuric acid; iron / ethanol; water / 1.5 h / Reflux 4.2: 25 °C |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With hydrogenchloride; sodium chloride Irradiation; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
34% | Stage #1: nitroveratryloxycarbonyl chloride; ethidium Bromide With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide for 16h; Darkness; Inert atmosphere; Stage #2: trifluoroacetic acid In water; acetonitrile |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In methanol at 20℃; for 0.333333h; | Synthetic of the solid CT complexes General procedure: The solid CT complexes of EtBr with QL, PA, TCNQ or DDQ were synthesized by mixing 1 mmol EtBr with 2 mmol of each acceptor in methanol (10 ml). The mixtures were stirred at room temperature for 20 min, which resulted in the precipitation of the solid CT complexes. The solid precipitates were filtered, washed several times with methanol, and then dried under vacuum over anhydrous calcium chloride. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In methanol at 20℃; for 0.333333h; | Synthetic of the solid CT complexes General procedure: The solid CT complexes of EtBr with QL, PA, TCNQ or DDQ were synthesized by mixing 1 mmol EtBr with 2 mmol of each acceptor in methanol (10 ml). The mixtures were stirred at room temperature for 20 min, which resulted in the precipitation of the solid CT complexes. The solid precipitates were filtered, washed several times with methanol, and then dried under vacuum over anhydrous calcium chloride. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In methanol at 20℃; for 0.333333h; | Synthetic of the solid CT complexes General procedure: The solid CT complexes of EtBr with QL, PA, TCNQ or DDQ were synthesized by mixing 1 mmol EtBr with 2 mmol of each acceptor in methanol (10 ml). The mixtures were stirred at room temperature for 20 min, which resulted in the precipitation of the solid CT complexes. The solid precipitates were filtered, washed several times with methanol, and then dried under vacuum over anhydrous calcium chloride. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In methanol at 20℃; for 0.333333h; | Synthetic of the solid CT complexes General procedure: The solid CT complexes of EtBr with QL, PA, TCNQ or DDQ were synthesized by mixing 1 mmol EtBr with 2 mmol of each acceptor in methanol (10 ml). The mixtures were stirred at room temperature for 20 min, which resulted in the precipitation of the solid CT complexes. The solid precipitates were filtered, washed several times with methanol, and then dried under vacuum over anhydrous calcium chloride. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Stage #1: ethidium Bromide With dmap; N-ethyl-N,N-diisopropylamine In dichloromethane; N,N-dimethyl-formamide at 0℃; for 0.5h; Inert atmosphere; Stage #2: phosgene In dichloromethane; N,N-dimethyl-formamide at 0℃; for 3h; Inert atmosphere; Stage #3: p-hydroxymethylphenylboronic acid In dichloromethane; N,N-dimethyl-formamide at 20℃; for 24h; Inert atmosphere; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
17% | Stage #1: ethidium Bromide With dmap; N-ethyl-N,N-diisopropylamine In dichloromethane; N,N-dimethyl-formamide at 0℃; for 0.5h; Inert atmosphere; Stage #2: With phosgene In dichloromethane; N,N-dimethyl-formamide at 0℃; for 3h; Inert atmosphere; Stage #3: C32H43BN2O7S In dichloromethane; N,N-dimethyl-formamide at 20℃; for 24h; Inert atmosphere; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In 1,2-dimethoxyethane |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In aq. buffer |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In water at 37℃; for 2h; | 2.5. Synthesis of ethidium-HETE EthBr solution (10 mg/ml in water) was diluted (1:20,000) withwater. Afterwards, 198 ml of this solution was mixed with 2 ml ofdifferent SM solutions, which resulted in SM concentrations of 10,40, 100 or 1000 mM. Mixtures were incubated for 2 h at 37 C undergentle shaking to produce ethidium-hydroxyethylthioethyl derivatives(Eth-HETE). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Stage #1: ethidium Bromide With trifluoroacetic acid In dichloromethane; acetonitrile at 0℃; for 0.166667h; Inert atmosphere; Stage #2: With sodium nitrite In dichloromethane; acetonitrile at 0℃; for 0.0833333h; Inert atmosphere; Stage #3: N,N-diethylaniline Further stages; | 1 Example 1: Anti-tumor drug compound 1 of synthesis: (1) EB (230 mg) dissolved in 50 ml volume ratio of 0.01: 1:4 trifluoroacetic acid/b nitrile in the mixed solvent of methylene chloride /, the mixture under protection of nitrogen gas, in the 0 °C stirring under the conditions of 10 minutes. (1) EB (230 mg) dissolved in 50 ml volume ratio of 0.01: 1:4 trifluoroacetic acid/b nitrile in the mixed solvent of methylene chloride /, the mixture under protection of nitrogen gas, in the 0 °C stirring under the conditions of 10 minutes. (3) amino sulfonic acid (200 mg) is added to the step (2) in the resulting reaction solution, keep the 0 °C stirring reaction under the conditions of 10 minutes. (4) the N, N - two ethyl aniline (200μL) dissolved in 2 ml volume ratio of 0.01: 1:4 trifluoroacetic acid/b nitrile in the mixed solvent of methylene chloride /, is added to the step (3) in the resulting reaction solution, keep the 0 °C stirring for 60 minutes. (5) after the reaction is finished, the step (4) and the resulting reaction solution with dichloromethane dilution, water washing three times, the organic phase collected, dichloromethane is used for drying overnight.(6) the obtained product column chromatography method for the purification, the eluent is the volume ratio of 1:9 methanol/methylene chloride mixed solvent.(7) electrospray ionization mass spectrometry for characterization of the molecular structure of the compound, and the obtained products in -20 °C stored light conditions. As shown in Figure 1, electrospray ionization mass spectrometry results demonstrate that compound 1 successful synthesis. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
(1) EB (230 mg) dissolved in 50 ml volume ratio of 0.01: 1:4 trifluoroacetic acid/b nitrile in the mixed solvent of methylene chloride /, the mixture under protection of nitrogen gas, in the 0 C stirring under the conditions of 5 minutes.(2) the sodium nitrite (150 mg) is added to the step (1) in the resulting mixture, to maintain 0 C stirring for 10 minutes.(3) amino sulfonic acid (200 mg) is added to the step (2) in the resulting reaction solution, keep the 0 C stirring for 5 minutes.(4) the N, double-N - (2 - chloro ethyl) aniline (200muL) dissolved in 2 ml volume ratio of 0.01: 1:4 trifluoroacetic acid/b nitrile in the mixed solvent of methylene chloride /, is added to the step (3) the resulting reaction solution, maintain 0 C stirring for 60 minutes.(5) after the reaction is finished, the step (4) and the resulting reaction solution with dichloromethane dilution, water washing three times, the organic phase collected, dichloromethane is used for drying overnight.(6) the obtained product column chromatography method for the purification, the eluent is the volume ratio of 1:9 methanol/methylene chloride mixed solvent.(7) electrospray ionization mass spectrometry for characterization of the molecular structure of the compound, and the obtained products in -20 C stored light conditions.The results of the electrospray mass spectrum as shown in Figure 2, that compound 2 successful synthesis. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In aq. buffer at 24.84℃; | ||
In aq. buffer at 37℃; for 1h; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In aq. buffer |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In water-d2 | General procedure: For the stock standard solution of ethidium bromide(2.5 10-3 mol/L), 0.045 g of ET was dissolved in water, transferred into a 1000-mL standard flask and diluted to the mark with water, and mixed well. For the stock calixarenesolutions (0.5 mol/L), 0.42, 0.62, and 0.75 g of calix[n]arene(n: 4, 6 or 8) were weighted and dissolved in double-distilled water, respectively. A 1.0-mL portion of ET (1 mM) diluted appropriately with double-distilled water was transferred accurately into a 1-cm quartz cell containing different concentrationsof calixarene hosts (100-1000 μM) while the concentration of ET was fixed constant at 100 μM. The resultant mixture was subsequently incubated at 25, 35, and 45 °C for 15 min. Absorption spectra of ET in the presence and absence of calix[n]arenes were recorded in the range 200-600 nm in a UV-Vis spectrophotometer. The solutions were scanned (1200 nm/min) with 400 W of PMT voltage in a spectrofluorometer with the wavelength range 550-750 nm. The widths of slit for both the excitation and emission were adjusted at 10 nm. The fluorescence intensity at 618 nm was determined under the excitation at the wavelength of 525 nm. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In water-d2 | General procedure: For the stock standard solution of ethidium bromide(2.5 10-3 mol/L), 0.045 g of ET was dissolved in water, transferred into a 1000-mL standard flask and diluted to the mark with water, and mixed well. For the stock calixarenesolutions (0.5 mol/L), 0.42, 0.62, and 0.75 g of calix[n]arene(n: 4, 6 or 8) were weighted and dissolved in double-distilled water, respectively. A 1.0-mL portion of ET (1 mM) diluted appropriately with double-distilled water was transferred accurately into a 1-cm quartz cell containing different concentrationsof calixarene hosts (100-1000 μM) while the concentration of ET was fixed constant at 100 μM. The resultant mixture was subsequently incubated at 25, 35, and 45 °C for 15 min. Absorption spectra of ET in the presence and absence of calix[n]arenes were recorded in the range 200-600 nm in a UV-Vis spectrophotometer. The solutions were scanned (1200 nm/min) with 400 W of PMT voltage in a spectrofluorometer with the wavelength range 550-750 nm. The widths of slit for both the excitation and emission were adjusted at 10 nm. The fluorescence intensity at 618 nm was determined under the excitation at the wavelength of 525 nm. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
120 mg | With fuming sulphuric acid at 0 - 20℃; | 12 Example 12: Preparation of Sulfonated EtBr To 30% fuming sulthric acid (5 mL) at 0° C. wasethidium bromide (0.5 g, 1.26 mmol)(Aldrich cat: E8751- 25G) portionwise over a period of 15 minutes. The mixturewas stirred at 0° C. for 1 hr and then at room temperature overnight. The mixture was poured into Et20 (200 mL)was cooled at -70° C. The precipitate was collectedsuction filtration and then purified by column chromatography on silica gel to give Compound No. 1 as dark red solid(120 mg). MS calcd for C21H2QN3O3S [M=H] 394. found394. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In aq. phosphate buffer; dimethyl sulfoxide |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
85% | In acetonitrile at 85℃; for 24h; Inert atmosphere; |
Tags: 1239-45-8 synthesis path| 1239-45-8 SDS| 1239-45-8 COA| 1239-45-8 purity| 1239-45-8 application| 1239-45-8 NMR| 1239-45-8 COA| 1239-45-8 structure
Precautionary Statements-General | |
Code | Phrase |
P101 | If medical advice is needed,have product container or label at hand. |
P102 | Keep out of reach of children. |
P103 | Read label before use |
Prevention | |
Code | Phrase |
P201 | Obtain special instructions before use. |
P202 | Do not handle until all safety precautions have been read and understood. |
P210 | Keep away from heat/sparks/open flames/hot surfaces. - No smoking. |
P211 | Do not spray on an open flame or other ignition source. |
P220 | Keep/Store away from clothing/combustible materials. |
P221 | Take any precaution to avoid mixing with combustibles |
P222 | Do not allow contact with air. |
P223 | Keep away from any possible contact with water, because of violent reaction and possible flash fire. |
P230 | Keep wetted |
P231 | Handle under inert gas. |
P232 | Protect from moisture. |
P233 | Keep container tightly closed. |
P234 | Keep only in original container. |
P235 | Keep cool |
P240 | Ground/bond container and receiving equipment. |
P241 | Use explosion-proof electrical/ventilating/lighting/equipment. |
P242 | Use only non-sparking tools. |
P243 | Take precautionary measures against static discharge. |
P244 | Keep reduction valves free from grease and oil. |
P250 | Do not subject to grinding/shock/friction. |
P251 | Pressurized container: Do not pierce or burn, even after use. |
P260 | Do not breathe dust/fume/gas/mist/vapours/spray. |
P261 | Avoid breathing dust/fume/gas/mist/vapours/spray. |
P262 | Do not get in eyes, on skin, or on clothing. |
P263 | Avoid contact during pregnancy/while nursing. |
P264 | Wash hands thoroughly after handling. |
P265 | Wash skin thouroughly after handling. |
P270 | Do not eat, drink or smoke when using this product. |
P271 | Use only outdoors or in a well-ventilated area. |
P272 | Contaminated work clothing should not be allowed out of the workplace. |
P273 | Avoid release to the environment. |
P280 | Wear protective gloves/protective clothing/eye protection/face protection. |
P281 | Use personal protective equipment as required. |
P282 | Wear cold insulating gloves/face shield/eye protection. |
P283 | Wear fire/flame resistant/retardant clothing. |
P284 | Wear respiratory protection. |
P285 | In case of inadequate ventilation wear respiratory protection. |
P231 + P232 | Handle under inert gas. Protect from moisture. |
P235 + P410 | Keep cool. Protect from sunlight. |
Response | |
Code | Phrase |
P301 | IF SWALLOWED: |
P304 | IF INHALED: |
P305 | IF IN EYES: |
P306 | IF ON CLOTHING: |
P307 | IF exposed: |
P308 | IF exposed or concerned: |
P309 | IF exposed or if you feel unwell: |
P310 | Immediately call a POISON CENTER or doctor/physician. |
P311 | Call a POISON CENTER or doctor/physician. |
P312 | Call a POISON CENTER or doctor/physician if you feel unwell. |
P313 | Get medical advice/attention. |
P314 | Get medical advice/attention if you feel unwell. |
P315 | Get immediate medical advice/attention. |
P320 | |
P302 + P352 | IF ON SKIN: wash with plenty of soap and water. |
P321 | |
P322 | |
P330 | Rinse mouth. |
P331 | Do NOT induce vomiting. |
P332 | IF SKIN irritation occurs: |
P333 | If skin irritation or rash occurs: |
P334 | Immerse in cool water/wrap n wet bandages. |
P335 | Brush off loose particles from skin. |
P336 | Thaw frosted parts with lukewarm water. Do not rub affected area. |
P337 | If eye irritation persists: |
P338 | Remove contact lenses, if present and easy to do. Continue rinsing. |
P340 | Remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P341 | If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P342 | If experiencing respiratory symptoms: |
P350 | Gently wash with plenty of soap and water. |
P351 | Rinse cautiously with water for several minutes. |
P352 | Wash with plenty of soap and water. |
P353 | Rinse skin with water/shower. |
P360 | Rinse immediately contaminated clothing and skin with plenty of water before removing clothes. |
P361 | Remove/Take off immediately all contaminated clothing. |
P362 | Take off contaminated clothing and wash before reuse. |
P363 | Wash contaminated clothing before reuse. |
P370 | In case of fire: |
P371 | In case of major fire and large quantities: |
P372 | Explosion risk in case of fire. |
P373 | DO NOT fight fire when fire reaches explosives. |
P374 | Fight fire with normal precautions from a reasonable distance. |
P376 | Stop leak if safe to do so. Oxidising gases (section 2.4) 1 |
P377 | Leaking gas fire: Do not extinguish, unless leak can be stopped safely. |
P378 | |
P380 | Evacuate area. |
P381 | Eliminate all ignition sources if safe to do so. |
P390 | Absorb spillage to prevent material damage. |
P391 | Collect spillage. Hazardous to the aquatic environment |
P301 + P310 | IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
P301 + P312 | IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. |
P301 + P330 + P331 | IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. |
P302 + P334 | IF ON SKIN: Immerse in cool water/wrap in wet bandages. |
P302 + P350 | IF ON SKIN: Gently wash with plenty of soap and water. |
P303 + P361 + P353 | IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
P304 + P312 | IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. |
P304 + P340 | IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. |
P304 + P341 | IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P305 + P351 + P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
P306 + P360 | IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. |
P307 + P311 | IF exposed: call a POISON CENTER or doctor/physician. |
P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
Sorry,this product has been discontinued.
Home
* Country/Region
* Quantity Required :
* Cat. No.:
* CAS No :
* Product Name :
* Additional Information :