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Chemical Structure| 1239460-78-6 Chemical Structure| 1239460-78-6

Structure of 1239460-78-6

Chemical Structure| 1239460-78-6

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Product Details of [ 1239460-78-6 ]

CAS No. :1239460-78-6
Formula : C10H12BrNO2
M.W : 258.11
SMILES Code : COC(/C=N/C1=CC=CC=C1Br)OC

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Application In Synthesis of [ 1239460-78-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1239460-78-6 ]

[ 1239460-78-6 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1239460-78-6 ]
  • [ 63927-22-0 ]
YieldReaction ConditionsOperation in experiment
With sulfuric acid; at 130 - 140℃; for 0.5h; The oil was dropped into 5OmL of concentrated H2SO4 and the mixture was heated to 130-140 0C for 30mins, then the reaction mixture was poured into 50OmL if ice-water and adjust to pH~8 with 5N sodium hydroxide solution. The aqueous solution was extracted with DCM (250mLX5) and washed with water (3 x 5OmL). The combined organic layer was washed with brine, dried over Na2SO4 and the solvent was evaporated under vacuum. The crude solid was purified with silica gel to give 8- bromoisoquinoline (2.2g, two steps 10.6%).
 

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