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Chemical Structure| 1242179-00-5 Chemical Structure| 1242179-00-5

Structure of 1242179-00-5

Chemical Structure| 1242179-00-5

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Product Details of [ 1242179-00-5 ]

CAS No. :1242179-00-5
Formula : C17H23NO3
M.W : 289.37
SMILES Code : O=C(C(C1)CN(C2=C(C)C=CC=C2C)C1=O)OC(C)(C)C

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Application In Synthesis of [ 1242179-00-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1242179-00-5 ]

[ 1242179-00-5 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1242179-00-5 ]
  • [ 101166-65-8 ]
  • [ 1280200-73-8 ]
YieldReaction ConditionsOperation in experiment
60% Example 37: Synthesis of (lS*,5S*)-3-(2,6-dimethylphenyl)-4-oxo-3- azabicyclo[3.2.0]heptane-l-carboxylic acid [3,5-bis(trifluoromethyl)phenyl]amide step f[0184] a) LHMDS (1.0 M in THF, 13.4 mL, 13.4 mmol) was added to the solution of 1- (2,6-dimethylphenyl)-5-oxo-pyrrolidine-3-carboxylic acid tert-butyl ester (3.53 g, 12.2 mmol) in THF (6 mL) in a reaction flask cooled to -50 °C under nitrogen atmosphere. The reaction mixture was allowed to warm up to 0 °C (precipitate forms), whereupon tert-butyl- (2-iodoethoxy)-dimethylsilane (3.84 g, 13.4 mmol) was added and the mixture was thoroughly shaken. The reaction mixture was allowed to warm up to room temperature and was kept stirring for 1 h. 20 mL of half-saturated aqueous ammonium chloride solution was added, followed by 100 mL of DCM. The organic layer was concentrated in vacuo on silica gel and purified by flash chromatography (Si02, 5-35percent EtOAc/hexanes) to give 3.28 g of the desired compound (60percent yield). LC-MS Rt (retention time): 3.41 min, MS: (ES) mlz 448 (M+H+).
 

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