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Chemical Structure| 1247133-54-5 Chemical Structure| 1247133-54-5

Structure of 1247133-54-5

Chemical Structure| 1247133-54-5

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Product Details of [ 1247133-54-5 ]

CAS No. :1247133-54-5
Formula : C8H17NO
M.W : 143.23
SMILES Code : COCCCC1NCCC1

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Application In Synthesis of [ 1247133-54-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1247133-54-5 ]

[ 1247133-54-5 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1247133-54-5 ]
  • [ 132898-96-5 ]
  • [ 1428534-96-6 ]
YieldReaction ConditionsOperation in experiment
618 mg With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; chloroform; at 20℃; for 1h;Inert atmosphere; General procedure: A stirred solution of N-Boc protected pyrrolidine (1.00 mmol) in dry DCM (2.2 mL) at 0 C under argon atmosphere was treated dropwise with TFA (10.00 mmol). Stirring was continued at 0 C for 30 min and at ambient temperature for 2 h. Subsequently, the solution was poured to ice-cooled 10% aq NaOH (15 mL) and extracted with DCM (3 × 15 mL). The combined organic phase was dried over MgSO4 and concentrated in vacuo to obtain a colorless oil as the corresponding unprotected pyrrolidine. After that a solution of the free pyrrolidine and DIPEA (2.00 mmol) in CHCl3 (1.1 mL) was added dropwise to a stirred solution of 5-chlorosulfonyl isatin (1.50 mmol) in CHCl3/THF (1:1, 19 mL) at room temperature. The resulting solution was stirred at room temperature for 1 h and the solvent was completely removed in vacuo. The crude product was purified by flash column chromatography to obtain the corresponding inhibitors.
 

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