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Chemical Structure| 1249451-71-5 Chemical Structure| 1249451-71-5

Structure of 1249451-71-5

Chemical Structure| 1249451-71-5

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Product Details of [ 1249451-71-5 ]

CAS No. :1249451-71-5
Formula : C9H19N3
M.W : 169.27
SMILES Code : N1(C2CNCCC2)CCNCC1

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Application In Synthesis of [ 1249451-71-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1249451-71-5 ]

[ 1249451-71-5 ] Synthesis Path-Downstream   1~1

  • 1
  • 1-(tert-butoxycarbonyl)-piperizine [ No CAS ]
  • Sodium triacetoxyborahydride [ No CAS ]
  • [ 50606-58-1 ]
  • [ 1249451-71-5 ]
YieldReaction ConditionsOperation in experiment
With triethylamine;palladium; In ethanol; 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran; 1-Benzyl-3-piperidone hydrochloride (700 mg, 2.7 mmol), triethylamine (270 mg, 2.7 mmol) and 1-(tert-butoxycarbonyl)-piperizine (500 mg, 2.7 mmol) in DCM, was stirred at rt for 1 h, then heated to 50 C. for 40 min. Sodium triacetoxyborahydride (1.12 g, 5.3 mmol) was added and the reaction mixture allowed to cool, with stirring, over 12 h then concentrated to dryness in vacuo. The residue was partioned between DCM/water, the organics dried (MgSO4) and concentrated to dryness in vacuo. The resulting residue in EtOH (10 ml) was hydrogenated with 10% w/w palladium on carbon (200 mg) under hydrogen at rt for 18 h. The reaction was filtered through celite and concentrated to dryness in vacuo to give 3-piperazine-1-yl-piperidine as a pale yellow gum (700 mg, 2.6 mmol, 97%). 8H (CDCl3, 300K) 3.43-3.37 (4H, m br), 3.21 (1H, d br, J=11.6 Hz), 3.01 (1H, d br, J=12.2 Hz), 2.59-2.47 (6H, m br), 2.45-2.38 (1H, m), 1.99-1.92 (1H, m br), 1.82-1.75 (1H, m), 1.58-1.48 (1H, m), 1.45 (9H, s), 1.42-1.33 (1H, m). m/z (ES+, 70V) 270.3 (MH+).
 

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