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Chemical Structure| 1251333-53-5 Chemical Structure| 1251333-53-5

Structure of 1251333-53-5

Chemical Structure| 1251333-53-5

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Product Details of [ 1251333-53-5 ]

CAS No. :1251333-53-5
Formula : C9H11FN2
M.W : 166.20
SMILES Code : NC1=CC=C(F)C=C1NC2CC2
MDL No. :MFCD16744205

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Application In Synthesis of [ 1251333-53-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1251333-53-5 ]

[ 1251333-53-5 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1251333-53-5 ]
  • [ 72411-89-3 ]
  • N-(2-(cyclopropylamino)-4-fluorophenyl)-4-methoxypyrimidine-5-carboxamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 20℃; for 4h;Inert atmosphere; To a stirred solution of N1-cyclopropyl-5-fluorobenzene-1,2-diamine Int-1 (300 mg, 1.81 mmol) in DMF (4 mL) under an inert atmosphere was added <strong>[72411-89-3]4-methoxypyrimidine-5-carboxylic acid</strong> (278 mg, 1.81 mmol), HATU (824 mg, 2.17 mmol) and ethyldiisopropylamine (1.26 mL, 7.23 mmol) drop wise at room temperature. The reaction mixture was stirred at room temperature for 4 h. After consumption of starting material (by TLC), the reaction mixture was quenched with water (20 mL) and extracted with Et2O (2*20 mL). The combined organic extracts were dried over anhydrous Na2SO4 and concentrated under reduced pressure to obtain N-(2-(cyclopropylamino)-4-fluorophenyl)-4-methoxypyrimidine-5-carboxamide (250 mg, crude) as brown solid which was used directly without further purification. LC-MS: m/z 302.9 [M+H]+ at 3.01 RT (97.99percent purity).
 

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