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[ CAS No. 1254473-68-1 ] {[proInfo.proName]}

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Product Details of [ 1254473-68-1 ]

CAS No. :1254473-68-1 MDL No. :MFCD22665798
Formula : C7H7Cl2NO Boiling Point : -
Linear Structure Formula :- InChI Key :KCPDCYCCMCEYQN-SCSAIBSYSA-N
M.W : 192.04 Pubchem ID :78357890
Synonyms :

Safety of [ 1254473-68-1 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 1254473-68-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1254473-68-1 ]

[ 1254473-68-1 ] Synthesis Path-Downstream   1~50

  • 1
  • [ 1370347-50-4 ]
  • (R)-1-(3,5-dichloropyridin-4-yl)ethan-1-ol [ No CAS ]
  • 2
  • [ CAS Unavailable ]
  • [ 1254473-68-1 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1: sodium hydroxide / water; ethanol / 2 h / 20 °C 2: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 0 - 20 °C 3: sodium hydroxide / water; ethanol / 20 °C
  • 3
  • C16H13Cl4NO3 [ No CAS ]
  • [ 1370347-50-4 ]
  • (R)-1-(3,5-dichloropyridin-4-yl)ethan-1-ol [ No CAS ]
  • 4
  • [ 1989596-75-9 ]
  • [ 1254473-68-1 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1: sodium hydroxide / water; ethanol / 2 h / 20 °C 2: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 0 - 20 °C 3: sodium hydroxide / water; ethanol / 20 °C
  • 7
  • [ 2457-47-8 ]
  • [ 1254473-68-1 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 5 steps 1: N-ethyl-N,N-diisopropylamine; n-butyllithium / tetrahydrofuran; hexane / -78 °C 2: dmap; dicyclohexyl-carbodiimide / toluene / 0 °C 3: sodium hydroxide / water; ethanol / 2 h / 20 °C 4: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 0 - 20 °C 5: sodium hydroxide / water; ethanol / 20 °C
Multi-step reaction with 5 steps 1: N-ethyl-N,N-diisopropylamine; n-butyllithium / tetrahydrofuran; hexane / -78 °C 2: dmap; dicyclohexyl-carbodiimide / toluene / 0 °C 3: sodium hydroxide / water; ethanol / 2 h / 20 °C 4: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 0 - 20 °C 5: sodium hydroxide / water; ethanol / 20 °C
Multi-step reaction with 3 steps 1: n-butyllithium; diisopropylamine / tetrahydrofuran / 3 h / -78 °C 2: pyridinium chlorochromate / dichloromethane / 10 h / 20 °C 3: (S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole; dimethylsulfide borane complex / dichloromethane / 12 h / -10 °C
  • 8
  • [ 1254473-68-1 ]
  • [ 124-63-0 ]
  • [ 1254473-70-5 ]
YieldReaction ConditionsOperation in experiment
91% With triethylamine In dichloromethane Cooling with ice; 4 (R) -1- (3,5-dichloropyridin-4-yl) ethyl methanesulfonate (V) A solution of (R) -1- (3,5-dichloropyridin-4-yl) ethanol (IV) (4.5 g, 23.43 mmol) and triethylamine (8.54 g, 84.35 mmol) in anhydrous dichloromethane 100 ml), and methanesulfonyl chloride (3.22 g, 28.12 mmol) was added dropwise under ice-cooling.The reaction solution was poured into saturated sodium bicarbonate solution, the organic layer was separated, and the organic layer was washed with methylene chloride, and the organic layer was combined and the organic layer was washed with saturated brine. The organic layer was washed three times with the organic layer and the organic layer After drying over anhydrous sodium sulfate, the dichloromethane was distilled off under reduced pressure and purified by silica gel column chromatography (petroleum ether: ethyl acetate = 20: 1) to give 5.78 g of pure white crystals in 91% yield.
With triethylamine In dichloromethane at 20℃; for 1h; 6 Synthesis Intermediate 6-1: 5-((R)-1-(3,5-Dichloropyridin-4-yl)ethoxy)-1-(tetrahydro-2H-pyran-2-yl)- 1H-indazole-3-carbaldehyde (S)-1-(3,5-Dichloropyridin-4-yl)ethan-1-ol (200.0mg, 1.05mmol) and triethylamine (317.6mg, 3.14mmol) were dissolved in 20ml DCM, 0 Methanesulfonyl chloride (131.9 mg, 1.15 mmol) was added dropwise to the reaction solution, and reacted at room temperature for 1 hour. The reaction solution was quenched by adding water, extracted with dichloromethane twice, and the organic phases were combined, washed with saturated brine, dried over anhydrous sodium sulfate, and concentrated. Dissolve 1-4 (270.0mg, 1.09mmol) and the concentrate in 20ml DMF, add cesium carbonate (684.2mg, 2.10mmol), and react at 60°C for 16 hours. Water was added to the reaction solution, extracted twice with ethyl acetate, the organic phases were combined, washed with saturated brine, dried over anhydrous sodium sulfate, concentrated, and purified by silica gel column to obtain 289.3 mg of Intermediate 6-1 with a yield of 65.5%.
With triethylamine In dichloromethane at 0℃; for 0.5h;
  • 9
  • [ 402561-66-4 ]
  • [ 1254473-68-1 ]
YieldReaction ConditionsOperation in experiment
98% With dimethylsulfide borane complex; (S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole In dichloromethane at -10℃; for 12h; 3 (R)-1-(3,5-dichloropyridin-4-yl)ethanol (IV) A solution of (S) -2-methyl-CBS-oxazaborolidine (1 M in toluene, 5.3 ml, 5.26 mmol) and borane dimethyl sulfide complex (BH3-dMS, 10M dimethyl sulfide solution, 13.2 ml, 131.5 mmol) was dissolved in anhydrous dichloromethane (DCM, 100 ml),stirred at10°C for 10 min, and 3,5-dichloro-4- Acetylpyridine (III) (5 g, 26.3 mmol) in DCM (30 ml) was added dropwise to 10oC for 12 h, slowly warmed to room temperature and slowly dripped into the methanol quenching reaction.Drop finished, 70oC reflow 3h.The crude product was purified by silica gel column chromatography (petroleum ether: ethyl acetate = 20: 1) to give 4.87 g of a colorless oil; 96% yield and 98.14% ee
  • 10
  • [ 1254473-68-1 ]
  • [ 2745123-43-5 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 4 steps 1.1: triethylamine / dichloromethane / 1 h / 20 °C 2.1: caesium carbonate / N,N-dimethyl-formamide / 16 h / 60 °C 3.1: potassium permanganate; water / acetonitrile / 16 h / 20 °C 4.1: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 3 h / 20 °C 4.2: 2 h / 50 °C
  • 11
  • [ 1254473-68-1 ]
  • [ 2081148-50-5 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: triethylamine / dichloromethane / 1 h / 20 °C 2: caesium carbonate / N,N-dimethyl-formamide / 16 h / 60 °C
  • 12
  • [ 1254473-68-1 ]
  • [ 2745125-11-3 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1: triethylamine / dichloromethane / 1 h / 20 °C 2: caesium carbonate / N,N-dimethyl-formamide / 16 h / 60 °C 3: potassium permanganate; water / acetonitrile / 16 h / 20 °C
  • 13
  • [ 1254473-68-1 ]
  • [ 2745121-90-6 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 4 steps 1.1: triethylamine / dichloromethane / 1 h / 20 °C 2.1: caesium carbonate / N,N-dimethyl-formamide / 16 h / 60 °C 3.1: potassium permanganate; water / acetonitrile / 16 h / 20 °C 4.1: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 3 h / 20 °C 4.2: 1 h / 50 °C
  • 14
  • [ 1254473-68-1 ]
  • [ 2745121-94-0 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 4 steps 1.1: triethylamine / dichloromethane / 1 h / 20 °C 2.1: caesium carbonate / N,N-dimethyl-formamide / 16 h / 60 °C 3.1: potassium permanganate; water / acetonitrile / 16 h / 20 °C 4.1: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 3 h / 20 °C 4.2: 1 h / 50 °C
  • 15
  • [ 1254473-68-1 ]
  • [ 2765240-96-6 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1: triethylamine / dichloromethane / 0.5 h / 0 °C 2: Cs2CO3 / acetonitrile / Heating 3: Cs2CO3; tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / toluene / 90 °C / Inert atmosphere
  • 16
  • [ 1254473-68-1 ]
  • [ 2765241-03-8 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1: triethylamine / dichloromethane / 0.5 h / 0 °C 2: Cs2CO3 / acetonitrile / Heating 3: Cs2CO3; tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / toluene / 90 °C / Inert atmosphere
  • 17
  • [ 1254473-68-1 ]
  • [ 2765241-05-0 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1: triethylamine / dichloromethane / 0.5 h / 0 °C 2: Cs2CO3 / acetonitrile / Heating 3: Cs2CO3; tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / toluene / 90 °C / Inert atmosphere
  • 18
  • [ 1254473-68-1 ]
  • [ 2765241-07-2 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1: triethylamine / dichloromethane / 0.5 h / 0 °C 2: Cs2CO3 / acetonitrile / Heating 3: Cs2CO3; tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / toluene / 90 °C / Inert atmosphere
  • 19
  • [ 1254473-68-1 ]
  • [ 2765241-09-4 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1: triethylamine / dichloromethane / 0.5 h / 0 °C 2: Cs2CO3 / acetonitrile / Heating 3: Cs2CO3; tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / toluene / 90 °C / Inert atmosphere
  • 20
  • [ 1254473-68-1 ]
  • [ 2765241-11-8 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1: triethylamine / dichloromethane / 0.5 h / 0 °C 2: Cs2CO3 / acetonitrile / Heating 3: Cs2CO3; tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / toluene / 90 °C / Inert atmosphere
  • 21
  • [ 1254473-68-1 ]
  • [ 2765241-13-0 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1: triethylamine / dichloromethane / 0.5 h / 0 °C 2: Cs2CO3 / acetonitrile / Heating 3: Cs2CO3; tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / toluene / 90 °C / Inert atmosphere
  • 22
  • [ 1254473-68-1 ]
  • [ 2765241-15-2 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1: triethylamine / dichloromethane / 0.5 h / 0 °C 2: Cs2CO3 / acetonitrile / Heating 3: Cs2CO3; tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / toluene / 90 °C / Inert atmosphere
  • 23
  • [ 1254473-68-1 ]
  • [ 2765241-18-5 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1: triethylamine / dichloromethane / 0.5 h / 0 °C 2: Cs2CO3 / acetonitrile / Heating 3: Cs2CO3; tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / toluene / 90 °C / Inert atmosphere
  • 24
  • [ 1254473-68-1 ]
  • [ 2765241-19-6 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1: triethylamine / dichloromethane / 0.5 h / 0 °C 2: Cs2CO3 / acetonitrile / Heating 3: Cs2CO3; tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / toluene / 90 °C / Inert atmosphere
  • 25
  • [ 1254473-68-1 ]
  • [ 2765241-20-9 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1: triethylamine / dichloromethane / 0.5 h / 0 °C 2: Cs2CO3 / acetonitrile / Heating 3: Cs2CO3; tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / toluene / 90 °C / Inert atmosphere
  • 26
  • [ 1254473-68-1 ]
  • [ 2765241-22-1 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1: triethylamine / dichloromethane / 0.5 h / 0 °C 2: Cs2CO3 / acetonitrile / Heating 3: Cs2CO3; tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / toluene / 90 °C / Inert atmosphere
  • 27
  • [ 1254473-68-1 ]
  • [ 2765241-26-5 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1: triethylamine / dichloromethane / 0.5 h / 0 °C 2: Cs2CO3 / acetonitrile / Heating 3: Cs2CO3; tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / toluene / 90 °C / Inert atmosphere
  • 28
  • [ 1254473-68-1 ]
  • [ 2765241-24-3 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1: triethylamine / dichloromethane / 0.5 h / 0 °C 2: Cs2CO3 / acetonitrile / Heating 3: Cs2CO3; tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / toluene / 90 °C / Inert atmosphere
  • 29
  • [ 1254473-68-1 ]
  • [ 2765241-28-7 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1: triethylamine / dichloromethane / 0.5 h / 0 °C 2: Cs2CO3 / acetonitrile / Heating 3: Cs2CO3; tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / toluene / 90 °C / Inert atmosphere
  • 30
  • [ 1254473-68-1 ]
  • [ 2765241-29-8 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1: triethylamine / dichloromethane / 0.5 h / 0 °C 2: Cs2CO3 / acetonitrile / Heating 3: Cs2CO3; tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / toluene / 90 °C / Inert atmosphere
  • 31
  • [ 1254473-68-1 ]
  • [ 2765241-30-1 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1: triethylamine / dichloromethane / 0.5 h / 0 °C 2: Cs2CO3 / acetonitrile / Heating 3: Cs2CO3; tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / toluene / 90 °C / Inert atmosphere
  • 32
  • [ 1254473-68-1 ]
  • [ 2765241-31-2 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1: triethylamine / dichloromethane / 0.5 h / 0 °C 2: Cs2CO3 / acetonitrile / Heating 3: Cs2CO3; tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / toluene / 90 °C / Inert atmosphere
  • 33
  • [ 1254473-68-1 ]
  • [ 2765241-32-3 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1: triethylamine / dichloromethane / 0.5 h / 0 °C 2: Cs2CO3 / acetonitrile / Heating 3: Cs2CO3; tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / toluene / 90 °C / Inert atmosphere
  • 34
  • [ 1254473-68-1 ]
  • [ 2765241-51-6 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1: triethylamine / dichloromethane / 0.5 h / 0 °C 2: Cs2CO3 / acetonitrile / Heating 3: Cs2CO3; tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / toluene / 90 °C / Inert atmosphere
  • 35
  • [ 1254473-68-1 ]
  • [ 2765240-63-7 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 4 steps 1: triethylamine / dichloromethane / 0.5 h / 0 °C 2: Cs2CO3 / acetonitrile / Heating 3: Cs2CO3; tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / toluene / 90 °C / Inert atmosphere 4: ammonia hydrochloride; iron(0) / water monomer; ethanol / 0.5 h / Heating
  • 36
  • [ 1254473-68-1 ]
  • [ 2765240-73-9 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 4 steps 1: triethylamine / dichloromethane / 0.5 h / 0 °C 2: Cs2CO3 / acetonitrile / Heating 3: Cs2CO3; tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / toluene / 90 °C / Inert atmosphere 4: ammonia hydrochloride; iron(0) / water monomer; ethanol / 0.5 h / Heating
  • 37
  • [ 1254473-68-1 ]
  • [ 2765240-75-1 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 4 steps 1: triethylamine / dichloromethane / 0.5 h / 0 °C 2: Cs2CO3 / acetonitrile / Heating 3: Cs2CO3; tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / toluene / 90 °C / Inert atmosphere 4: ammonia hydrochloride; iron(0) / water monomer; ethanol / 0.5 h / Heating
  • 38
  • [ 1254473-68-1 ]
  • [ 2765240-77-3 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 4 steps 1: triethylamine / dichloromethane / 0.5 h / 0 °C 2: Cs2CO3 / acetonitrile / Heating 3: Cs2CO3; tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / toluene / 90 °C / Inert atmosphere 4: ammonia hydrochloride; iron(0) / water monomer; ethanol / 0.5 h / Heating
  • 39
  • [ 1254473-68-1 ]
  • [ 2765240-79-5 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 4 steps 1: triethylamine / dichloromethane / 0.5 h / 0 °C 2: Cs2CO3 / acetonitrile / Heating 3: Cs2CO3; tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / toluene / 90 °C / Inert atmosphere 4: ammonia hydrochloride; iron(0) / water monomer; ethanol / 0.5 h / Heating
  • 40
  • [ 1254473-68-1 ]
  • [ 2765240-80-8 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 4 steps 1: triethylamine / dichloromethane / 0.5 h / 0 °C 2: Cs2CO3 / acetonitrile / Heating 3: Cs2CO3; tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / toluene / 90 °C / Inert atmosphere 4: ammonia hydrochloride; iron(0) / water monomer; ethanol / 0.5 h / Heating
  • 41
  • [ 1254473-68-1 ]
  • [ 2765240-82-0 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 4 steps 1: triethylamine / dichloromethane / 0.5 h / 0 °C 2: Cs2CO3 / acetonitrile / Heating 3: Cs2CO3; tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / toluene / 90 °C / Inert atmosphere 4: ammonia hydrochloride; iron(0) / water monomer; ethanol / 0.5 h / Heating
  • 42
  • [ 1254473-68-1 ]
  • [ 2765240-84-2 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 4 steps 1: triethylamine / dichloromethane / 0.5 h / 0 °C 2: Cs2CO3 / acetonitrile / Heating 3: Cs2CO3; tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / toluene / 90 °C / Inert atmosphere 4: ammonia hydrochloride; iron(0) / water monomer; ethanol / 0.5 h / Heating
  • 43
  • [ 1254473-68-1 ]
  • [ 2765240-85-3 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 4 steps 1: triethylamine / dichloromethane / 0.5 h / 0 °C 2: Cs2CO3 / acetonitrile / Heating 3: Cs2CO3; tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / toluene / 90 °C / Inert atmosphere 4: ammonia hydrochloride; iron(0) / water monomer; ethanol / 0.5 h / Heating
  • 44
  • [ 1254473-68-1 ]
  • [ 2765240-86-4 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 4 steps 1: triethylamine / dichloromethane / 0.5 h / 0 °C 2: Cs2CO3 / acetonitrile / Heating 3: Cs2CO3; tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / toluene / 90 °C / Inert atmosphere 4: ammonia hydrochloride; iron(0) / water monomer; ethanol / 0.5 h / Heating
  • 45
  • [ 1254473-68-1 ]
  • [ 2765240-87-5 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 4 steps 1: triethylamine / dichloromethane / 0.5 h / 0 °C 2: Cs2CO3 / acetonitrile / Heating 3: Cs2CO3; tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / toluene / 90 °C / Inert atmosphere 4: ammonia hydrochloride; iron(0) / water monomer; ethanol / 0.5 h / Heating
  • 46
  • [ 1254473-68-1 ]
  • [ 2765240-88-6 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 4 steps 1: triethylamine / dichloromethane / 0.5 h / 0 °C 2: Cs2CO3 / acetonitrile / Heating 3: Cs2CO3; tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / toluene / 90 °C / Inert atmosphere 4: ammonia hydrochloride; iron(0) / water monomer; ethanol / 0.5 h / Heating
  • 47
  • [ 1254473-68-1 ]
  • [ 2765240-90-0 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 4 steps 1: triethylamine / dichloromethane / 0.5 h / 0 °C 2: Cs2CO3 / acetonitrile / Heating 3: Cs2CO3; tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / toluene / 90 °C / Inert atmosphere 4: ammonia hydrochloride; iron(0) / water monomer; ethanol / 0.5 h / Heating
  • 48
  • [ 1254473-68-1 ]
  • [ 2765240-89-7 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 4 steps 1: triethylamine / dichloromethane / 0.5 h / 0 °C 2: Cs2CO3 / acetonitrile / Heating 3: Cs2CO3; tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / toluene / 90 °C / Inert atmosphere 4: ammonia hydrochloride; iron(0) / water monomer; ethanol / 0.5 h / Heating
  • 49
  • [ 1254473-68-1 ]
  • [ 2765240-91-1 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 4 steps 1: triethylamine / dichloromethane / 0.5 h / 0 °C 2: Cs2CO3 / acetonitrile / Heating 3: Cs2CO3; tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / toluene / 90 °C / Inert atmosphere 4: ammonia hydrochloride; iron(0) / water monomer; ethanol / 0.5 h / Heating
  • 50
  • [ 1708974-11-1 ]
  • [ 1254473-68-1 ]
  • [ CAS Unavailable ]
YieldReaction ConditionsOperation in experiment
40 % With sodium hydride In tetrahydrofuran at 20℃;
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Technical Information

• Acid-Catalyzed α -Halogenation of Ketones • Add Hydrogen Cyanide to Aldehydes and Ketones to Produce Alcohols • Addition of a Hydrogen Halide to an Internal Alkyne • Alcohol Syntheses from Aldehydes, Ketones and Organometallics • Alcohols are Weakly Basic • Alcohols as Acids • Alcohols Convert Acyl Chlorides into Esters • Alcohols from Haloalkanes by Acetate Substitution-Hydrolysis • Alcohols React with PX3 • Alcoholysis of Anhydrides • Aldehydes and Ketones Form Hemiacetals Reversibly • Aldol Addition • Alkene Hydration • Alkene Hydration • Alkyl Halide Occurrence • Alkylation of an Alkynyl Anion • An Alkane are Prepared from an Haloalkane • Appel Reaction • Base-Catalyzed Hydration of α,β -Unsaturated Aldehydes and Ketones • Buchwald-Hartwig C-N Bond and C-O Bond Formation Reactions • Carboxylic Acids React with Alcohols to Form Esters • Chichibabin Reaction • Chloroalkane Synthesis with SOCI2 • Chromium Reagents for Alcohol Oxidation • Chugaev Reaction • Claisen Condensations Produce β-Dicarbonyl Compounds • Claisen Condensations Produce β-Dicarbonyl Compounds • Convert Esters into Aldehydes Using a Milder Reducing Agent • Convert Haloalkanes into Alcohols by SN2 • Corey-Kim Oxidation • Decarboxylation of 3-Ketoacids Yields Ketones • Decomposition of Lithium Aluminum Hydride by Protic Solvents • Dess-Martin Oxidation • Esters Are Reduced by LiAlH4 to Give Alcohols • Esters Hydrolyze to Carboxylic Acids and Alcohols • Ether Synthesis by Oxymercuration-Demercuration • Ethers Synthesis from Alcohols with Strong Acids • Friedel-Crafts Alkylation of Benzene with Haloalkanes • Friedel-Crafts Alkylations Using Alcohols • Geminal Diols and Acetals Can Be Hydrolyzed to Carbonyl Compounds • General Reactivity • Grignard Reaction • Grignard Reagents Transform Esters into Alcohols • Grignard Reagents Transform Esters into Alcohols • Haloalcohol Formation from an Alkene Through Electrophilic Addition • Halogen and Alcohols Add to Alkenes by Electrophilic Attack • Halogen and Alcohols Add to Alkenes by Electrophilic Attack • Halogenation of Alkenes • Hantzsch Pyridine Synthesis • Hemiaminal Formation from Amines and Aldehydes or Ketones • Hemiaminal Formation from Amines and Aldehydes or Ketones • HIO4 Oxidatively Degrades Vicinal Diols to Give Carbonyl Derivatives • Hiyama Cross-Coupling Reaction • Hydration of the Carbonyl Group • Hydride Reductions • Hydride Reductions of Aldehydes and Ketones to Alcohols • Hydride Reductions of Aldehydes and Ketones to Alcohols • Hydroboration-Oxidation • Hydroboration-Oxidation • Hydrolysis of Haloalkanes • Jones Oxidation • Ketones Undergo Mixed Claisen Reactions to Form β-Dicarbonyl Compounds • Kinetics of Alkyl Halides • Kumada Cross-Coupling Reaction • Martin's Sulfurane Dehydrating Reagent • Methylation of Ammonia • Mitsunobu Reaction • Moffatt Oxidation • Osmium Tetroxide Reacts with Alkenes to Give Vicinal Diols • Osmium TetroxideReacts with Alkenes to Give Vicinal Diols • Oxidation of Alcohols by DMSO • Oxymercuration-Demercuration • Preparation of Alcohols • Preparation of Alkenes by Dehydration of Alcohols • Preparation of Alkenes by Dehydration of Alcohols • Preparation of Alkoxides with Alkyllithium • Preparation of Amines • Primary Ether Cleavage with Strong Nucleophilic Acids • Pyridines React with Grignard or Organolithium Reagents • Reactions of Alcohols • Reactions of Alkyl Halides with Reducing Metals • Reactions of Amines • Reactions with Organometallic Reagents • Reduction of an Ester to an Alcohol • Reduction of Carboxylic Acids by LiAlH4 • Reduction of Carboxylic Acids by Lithium Aluminum Hydride • Reduction of Carboxylic Acids by Lithium Aluminum Hydride • Ring Opening of an Oxacyclopropane by Lithium Aluminum Hydride • Ritter Reaction • Sharpless Olefin Synthesis • Stille Coupling • Substitution and Elimination Reactions of Alkyl Halides • Suzuki Coupling • Swern Oxidation • Synthesis of Alcohols from Tertiary Ethers • Synthesis of an Alkyl Sulfonate • The Nucleophilic Opening of Oxacyclopropanes • Thiazolium Salt Catalysis in Aldehyde Coupling • Thiazolium Salts Catalyze Aldehyde Coupling • Thiazolium Salts Catalyze Aldehyde Coupling • Transesterification • Use 1,3-dithiane to Prepare of α-Hydroxyketones • Vicinal Anti Dihydroxylation of Alkenes • Williamson Ether Syntheses
Historical Records

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Related Parent Nucleus of
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