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CAS No. : | 1254473-68-1 | MDL No. : | MFCD22665798 |
Formula : | C7H7Cl2NO | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | KCPDCYCCMCEYQN-SCSAIBSYSA-N |
M.W : | 192.04 | Pubchem ID : | 78357890 |
Synonyms : |
|
Signal Word: | Warning | Class: | N/A |
Precautionary Statements: | P261-P305+P351+P338 | UN#: | N/A |
Hazard Statements: | H315-H319-H335 | Packing Group: | N/A |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 3 steps 1: sodium hydroxide / water; ethanol / 2 h / 20 °C 2: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 0 - 20 °C 3: sodium hydroxide / water; ethanol / 20 °C |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 3 steps 1: sodium hydroxide / water; ethanol / 2 h / 20 °C 2: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 0 - 20 °C 3: sodium hydroxide / water; ethanol / 20 °C |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With sodium hydroxide In ethanol; water at 20℃; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 5 steps 1: N-ethyl-N,N-diisopropylamine; n-butyllithium / tetrahydrofuran; hexane / -78 °C 2: dmap; dicyclohexyl-carbodiimide / toluene / 0 °C 3: sodium hydroxide / water; ethanol / 2 h / 20 °C 4: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 0 - 20 °C 5: sodium hydroxide / water; ethanol / 20 °C | ||
Multi-step reaction with 5 steps 1: N-ethyl-N,N-diisopropylamine; n-butyllithium / tetrahydrofuran; hexane / -78 °C 2: dmap; dicyclohexyl-carbodiimide / toluene / 0 °C 3: sodium hydroxide / water; ethanol / 2 h / 20 °C 4: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 0 - 20 °C 5: sodium hydroxide / water; ethanol / 20 °C | ||
Multi-step reaction with 3 steps 1: n-butyllithium; diisopropylamine / tetrahydrofuran / 3 h / -78 °C 2: pyridinium chlorochromate / dichloromethane / 10 h / 20 °C 3: (S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole; dimethylsulfide borane complex / dichloromethane / 12 h / -10 °C |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
91% | With triethylamine In dichloromethane Cooling with ice; | 4 (R) -1- (3,5-dichloropyridin-4-yl) ethyl methanesulfonate (V) A solution of (R) -1- (3,5-dichloropyridin-4-yl) ethanol (IV) (4.5 g, 23.43 mmol) and triethylamine (8.54 g, 84.35 mmol) in anhydrous dichloromethane 100 ml), and methanesulfonyl chloride (3.22 g, 28.12 mmol) was added dropwise under ice-cooling.The reaction solution was poured into saturated sodium bicarbonate solution, the organic layer was separated, and the organic layer was washed with methylene chloride, and the organic layer was combined and the organic layer was washed with saturated brine. The organic layer was washed three times with the organic layer and the organic layer After drying over anhydrous sodium sulfate, the dichloromethane was distilled off under reduced pressure and purified by silica gel column chromatography (petroleum ether: ethyl acetate = 20: 1) to give 5.78 g of pure white crystals in 91% yield. |
With triethylamine In dichloromethane at 20℃; for 1h; | 6 Synthesis Intermediate 6-1: 5-((R)-1-(3,5-Dichloropyridin-4-yl)ethoxy)-1-(tetrahydro-2H-pyran-2-yl)- 1H-indazole-3-carbaldehyde (S)-1-(3,5-Dichloropyridin-4-yl)ethan-1-ol (200.0mg, 1.05mmol) and triethylamine (317.6mg, 3.14mmol) were dissolved in 20ml DCM, 0 Methanesulfonyl chloride (131.9 mg, 1.15 mmol) was added dropwise to the reaction solution, and reacted at room temperature for 1 hour. The reaction solution was quenched by adding water, extracted with dichloromethane twice, and the organic phases were combined, washed with saturated brine, dried over anhydrous sodium sulfate, and concentrated. Dissolve 1-4 (270.0mg, 1.09mmol) and the concentrate in 20ml DMF, add cesium carbonate (684.2mg, 2.10mmol), and react at 60°C for 16 hours. Water was added to the reaction solution, extracted twice with ethyl acetate, the organic phases were combined, washed with saturated brine, dried over anhydrous sodium sulfate, concentrated, and purified by silica gel column to obtain 289.3 mg of Intermediate 6-1 with a yield of 65.5%. | |
With triethylamine In dichloromethane at 0℃; for 0.5h; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
98% | With dimethylsulfide borane complex; (S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole In dichloromethane at -10℃; for 12h; | 3 (R)-1-(3,5-dichloropyridin-4-yl)ethanol (IV) A solution of (S) -2-methyl-CBS-oxazaborolidine (1 M in toluene, 5.3 ml, 5.26 mmol) and borane dimethyl sulfide complex (BH3-dMS, 10M dimethyl sulfide solution, 13.2 ml, 131.5 mmol) was dissolved in anhydrous dichloromethane (DCM, 100 ml),stirred at10°C for 10 min, and 3,5-dichloro-4- Acetylpyridine (III) (5 g, 26.3 mmol) in DCM (30 ml) was added dropwise to 10oC for 12 h, slowly warmed to room temperature and slowly dripped into the methanol quenching reaction.Drop finished, 70oC reflow 3h.The crude product was purified by silica gel column chromatography (petroleum ether: ethyl acetate = 20: 1) to give 4.87 g of a colorless oil; 96% yield and 98.14% ee |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 4 steps 1.1: triethylamine / dichloromethane / 1 h / 20 °C 2.1: caesium carbonate / N,N-dimethyl-formamide / 16 h / 60 °C 3.1: potassium permanganate; water / acetonitrile / 16 h / 20 °C 4.1: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 3 h / 20 °C 4.2: 2 h / 50 °C |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 2 steps 1: triethylamine / dichloromethane / 1 h / 20 °C 2: caesium carbonate / N,N-dimethyl-formamide / 16 h / 60 °C |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 3 steps 1: triethylamine / dichloromethane / 1 h / 20 °C 2: caesium carbonate / N,N-dimethyl-formamide / 16 h / 60 °C 3: potassium permanganate; water / acetonitrile / 16 h / 20 °C |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 4 steps 1.1: triethylamine / dichloromethane / 1 h / 20 °C 2.1: caesium carbonate / N,N-dimethyl-formamide / 16 h / 60 °C 3.1: potassium permanganate; water / acetonitrile / 16 h / 20 °C 4.1: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 3 h / 20 °C 4.2: 1 h / 50 °C |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 4 steps 1.1: triethylamine / dichloromethane / 1 h / 20 °C 2.1: caesium carbonate / N,N-dimethyl-formamide / 16 h / 60 °C 3.1: potassium permanganate; water / acetonitrile / 16 h / 20 °C 4.1: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 3 h / 20 °C 4.2: 1 h / 50 °C |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 3 steps 1: triethylamine / dichloromethane / 0.5 h / 0 °C 2: Cs2CO3 / acetonitrile / Heating 3: Cs2CO3; tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / toluene / 90 °C / Inert atmosphere |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 3 steps 1: triethylamine / dichloromethane / 0.5 h / 0 °C 2: Cs2CO3 / acetonitrile / Heating 3: Cs2CO3; tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / toluene / 90 °C / Inert atmosphere |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 3 steps 1: triethylamine / dichloromethane / 0.5 h / 0 °C 2: Cs2CO3 / acetonitrile / Heating 3: Cs2CO3; tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / toluene / 90 °C / Inert atmosphere |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 3 steps 1: triethylamine / dichloromethane / 0.5 h / 0 °C 2: Cs2CO3 / acetonitrile / Heating 3: Cs2CO3; tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / toluene / 90 °C / Inert atmosphere |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 3 steps 1: triethylamine / dichloromethane / 0.5 h / 0 °C 2: Cs2CO3 / acetonitrile / Heating 3: Cs2CO3; tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / toluene / 90 °C / Inert atmosphere |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 3 steps 1: triethylamine / dichloromethane / 0.5 h / 0 °C 2: Cs2CO3 / acetonitrile / Heating 3: Cs2CO3; tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / toluene / 90 °C / Inert atmosphere |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 3 steps 1: triethylamine / dichloromethane / 0.5 h / 0 °C 2: Cs2CO3 / acetonitrile / Heating 3: Cs2CO3; tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / toluene / 90 °C / Inert atmosphere |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 3 steps 1: triethylamine / dichloromethane / 0.5 h / 0 °C 2: Cs2CO3 / acetonitrile / Heating 3: Cs2CO3; tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / toluene / 90 °C / Inert atmosphere |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 3 steps 1: triethylamine / dichloromethane / 0.5 h / 0 °C 2: Cs2CO3 / acetonitrile / Heating 3: Cs2CO3; tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / toluene / 90 °C / Inert atmosphere |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 3 steps 1: triethylamine / dichloromethane / 0.5 h / 0 °C 2: Cs2CO3 / acetonitrile / Heating 3: Cs2CO3; tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / toluene / 90 °C / Inert atmosphere |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 3 steps 1: triethylamine / dichloromethane / 0.5 h / 0 °C 2: Cs2CO3 / acetonitrile / Heating 3: Cs2CO3; tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / toluene / 90 °C / Inert atmosphere |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 3 steps 1: triethylamine / dichloromethane / 0.5 h / 0 °C 2: Cs2CO3 / acetonitrile / Heating 3: Cs2CO3; tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / toluene / 90 °C / Inert atmosphere |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 3 steps 1: triethylamine / dichloromethane / 0.5 h / 0 °C 2: Cs2CO3 / acetonitrile / Heating 3: Cs2CO3; tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / toluene / 90 °C / Inert atmosphere |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 3 steps 1: triethylamine / dichloromethane / 0.5 h / 0 °C 2: Cs2CO3 / acetonitrile / Heating 3: Cs2CO3; tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / toluene / 90 °C / Inert atmosphere |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 3 steps 1: triethylamine / dichloromethane / 0.5 h / 0 °C 2: Cs2CO3 / acetonitrile / Heating 3: Cs2CO3; tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / toluene / 90 °C / Inert atmosphere |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 3 steps 1: triethylamine / dichloromethane / 0.5 h / 0 °C 2: Cs2CO3 / acetonitrile / Heating 3: Cs2CO3; tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / toluene / 90 °C / Inert atmosphere |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 3 steps 1: triethylamine / dichloromethane / 0.5 h / 0 °C 2: Cs2CO3 / acetonitrile / Heating 3: Cs2CO3; tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / toluene / 90 °C / Inert atmosphere |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 3 steps 1: triethylamine / dichloromethane / 0.5 h / 0 °C 2: Cs2CO3 / acetonitrile / Heating 3: Cs2CO3; tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / toluene / 90 °C / Inert atmosphere |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 3 steps 1: triethylamine / dichloromethane / 0.5 h / 0 °C 2: Cs2CO3 / acetonitrile / Heating 3: Cs2CO3; tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / toluene / 90 °C / Inert atmosphere |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 3 steps 1: triethylamine / dichloromethane / 0.5 h / 0 °C 2: Cs2CO3 / acetonitrile / Heating 3: Cs2CO3; tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / toluene / 90 °C / Inert atmosphere |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 4 steps 1: triethylamine / dichloromethane / 0.5 h / 0 °C 2: Cs2CO3 / acetonitrile / Heating 3: Cs2CO3; tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / toluene / 90 °C / Inert atmosphere 4: ammonia hydrochloride; iron(0) / water monomer; ethanol / 0.5 h / Heating |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 4 steps 1: triethylamine / dichloromethane / 0.5 h / 0 °C 2: Cs2CO3 / acetonitrile / Heating 3: Cs2CO3; tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / toluene / 90 °C / Inert atmosphere 4: ammonia hydrochloride; iron(0) / water monomer; ethanol / 0.5 h / Heating |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 4 steps 1: triethylamine / dichloromethane / 0.5 h / 0 °C 2: Cs2CO3 / acetonitrile / Heating 3: Cs2CO3; tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / toluene / 90 °C / Inert atmosphere 4: ammonia hydrochloride; iron(0) / water monomer; ethanol / 0.5 h / Heating |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 4 steps 1: triethylamine / dichloromethane / 0.5 h / 0 °C 2: Cs2CO3 / acetonitrile / Heating 3: Cs2CO3; tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / toluene / 90 °C / Inert atmosphere 4: ammonia hydrochloride; iron(0) / water monomer; ethanol / 0.5 h / Heating |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 4 steps 1: triethylamine / dichloromethane / 0.5 h / 0 °C 2: Cs2CO3 / acetonitrile / Heating 3: Cs2CO3; tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / toluene / 90 °C / Inert atmosphere 4: ammonia hydrochloride; iron(0) / water monomer; ethanol / 0.5 h / Heating |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 4 steps 1: triethylamine / dichloromethane / 0.5 h / 0 °C 2: Cs2CO3 / acetonitrile / Heating 3: Cs2CO3; tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / toluene / 90 °C / Inert atmosphere 4: ammonia hydrochloride; iron(0) / water monomer; ethanol / 0.5 h / Heating |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 4 steps 1: triethylamine / dichloromethane / 0.5 h / 0 °C 2: Cs2CO3 / acetonitrile / Heating 3: Cs2CO3; tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / toluene / 90 °C / Inert atmosphere 4: ammonia hydrochloride; iron(0) / water monomer; ethanol / 0.5 h / Heating |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 4 steps 1: triethylamine / dichloromethane / 0.5 h / 0 °C 2: Cs2CO3 / acetonitrile / Heating 3: Cs2CO3; tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / toluene / 90 °C / Inert atmosphere 4: ammonia hydrochloride; iron(0) / water monomer; ethanol / 0.5 h / Heating |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 4 steps 1: triethylamine / dichloromethane / 0.5 h / 0 °C 2: Cs2CO3 / acetonitrile / Heating 3: Cs2CO3; tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / toluene / 90 °C / Inert atmosphere 4: ammonia hydrochloride; iron(0) / water monomer; ethanol / 0.5 h / Heating |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 4 steps 1: triethylamine / dichloromethane / 0.5 h / 0 °C 2: Cs2CO3 / acetonitrile / Heating 3: Cs2CO3; tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / toluene / 90 °C / Inert atmosphere 4: ammonia hydrochloride; iron(0) / water monomer; ethanol / 0.5 h / Heating |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 4 steps 1: triethylamine / dichloromethane / 0.5 h / 0 °C 2: Cs2CO3 / acetonitrile / Heating 3: Cs2CO3; tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / toluene / 90 °C / Inert atmosphere 4: ammonia hydrochloride; iron(0) / water monomer; ethanol / 0.5 h / Heating |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 4 steps 1: triethylamine / dichloromethane / 0.5 h / 0 °C 2: Cs2CO3 / acetonitrile / Heating 3: Cs2CO3; tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / toluene / 90 °C / Inert atmosphere 4: ammonia hydrochloride; iron(0) / water monomer; ethanol / 0.5 h / Heating |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 4 steps 1: triethylamine / dichloromethane / 0.5 h / 0 °C 2: Cs2CO3 / acetonitrile / Heating 3: Cs2CO3; tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / toluene / 90 °C / Inert atmosphere 4: ammonia hydrochloride; iron(0) / water monomer; ethanol / 0.5 h / Heating |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 4 steps 1: triethylamine / dichloromethane / 0.5 h / 0 °C 2: Cs2CO3 / acetonitrile / Heating 3: Cs2CO3; tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / toluene / 90 °C / Inert atmosphere 4: ammonia hydrochloride; iron(0) / water monomer; ethanol / 0.5 h / Heating |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 4 steps 1: triethylamine / dichloromethane / 0.5 h / 0 °C 2: Cs2CO3 / acetonitrile / Heating 3: Cs2CO3; tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / toluene / 90 °C / Inert atmosphere 4: ammonia hydrochloride; iron(0) / water monomer; ethanol / 0.5 h / Heating |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
40 % | With sodium hydride In tetrahydrofuran at 20℃; |
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