Name: 125486-96-6|2-(Trimethylsilyl)ethanesulfonamide|98%
Brand: Ambeed
SKU: A534864
Rating: 96 (27 reviews)

1
[ 125486-96-6 ]
[ 142800-35-9 ]
[ 143544-41-6 ]

Yield	Reaction Conditions	Operation in experiment
82%	With iodonium(di-γ-collidine) perchlorate In dichloromethane
82%	With iodonium(di-γ-collidine) perchlorate In dichloromethane at 0℃; for 0.5h;

Reference： [1]Danishefsky, Samuel J.; Koseki, Koshi; Griffith, David A.; Gervay, Jacquelyn; Peterson, John M.; et al. [Journal of the American Chemical Society, 1992, vol. 114, # 21, p. 8331 - 8333]
[2]Danishefsky, Samuel J.; Gervay, Jacquelyn; Peterson, John M.; McDonald, Frank E.; Koseki, Koshi; Griffith, David A.; Oriyama, Takeshi; Marsden, Stephen P. [Journal of the American Chemical Society, 1995, vol. 117, # 7, p. 1940 - 1953]

2
[ 125486-96-6 ]
[ 115534-34-4 ]

Yield	Reaction Conditions	Operation in experiment
	With N,N-dichloro-p-toluenesulfonamide; thionyl chloride In benzene for 28h; Heating;
	With thionyl chloride In benzene for 48h; Heating;

Reference： [1]Garigipati; Tschaen; Weinreb [Journal of the American Chemical Society, 1990, vol. 112, # 9, p. 3475 - 3482]
[2]Sisko, Joseph; Weinreb, Steven M. [Journal of Organic Chemistry, 1990, vol. 55, # 1, p. 393 - 395]
[3]Schleusner, Marcel; Gais, Hans-Joachim; Koep, Stefan; Raabe, Gerhard [Journal of the American Chemical Society, 2002, vol. 124, # 26, p. 7789 - 7800]

3
[ 55628-54-1 ]
[ 125486-96-6 ]
[ 183989-07-3 ]

Yield	Reaction Conditions	Operation in experiment
78%	With iodonium(di-γ-collidine) perchlorate; 4 A molecular sieve In dichloromethane at 0℃;

Reference： [1]Griffith, David A.; Danishefsky, Samuel J. [Journal of the American Chemical Society, 1996, vol. 118, # 40, p. 9526 - 9538]

4
[ 14371-10-9 ]
[ 125486-96-6 ]
N-(trans-3-phenylprop-2-enylidene)-β-trimethylsilylethanesulfonamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
95%	With boron trifluoride diethyl etherate In toluene Heating;
69%	With boron trifluoride diethyl etherate In benzene Heating;

Reference： [1]Aggarwal; Ferrara; O'Brien; Thompson; Jones; Fieldhouse [Journal of the Chemical Society. Perkin Transactions 1 (2001), 2001, # 14, p. 1635 - 1643]
[2]Xu, Zhenrong; Lu, Xiyan [Journal of Organic Chemistry, 1998, vol. 63, # 15, p. 5031 - 5041]

5
[ 125486-96-6 ]
[ 100-52-7 ]
N-benzylidene-β-trimethylsilylethanesulfonamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
82%	With boron trifluoride diethyl etherate In benzene for 24h; Heating;
72%	With boron trifluoride diethyl etherate In toluene Heating;

Reference： [1]Xu, Zhenrong; Lu, Xiyan [Journal of Organic Chemistry, 1998, vol. 63, # 15, p. 5031 - 5041]
[2]Aggarwal; Ferrara; O'Brien; Thompson; Jones; Fieldhouse [Journal of the Chemical Society. Perkin Transactions 1 (2001), 2001, # 14, p. 1635 - 1643]

6
[ 3240-34-4 ]
[ 125486-96-6 ]
[ 236122-13-7 ]

Yield	Reaction Conditions	Operation in experiment
99%	With potassium hydroxide In methanol 1.) 0 deg C, 30 min, 2.) 20 deg C, 3 h;

Reference： [1]Dauban, Philippe; Dodd, Robert H. [Journal of Organic Chemistry, 1999, vol. 64, # 14, p. 5304 - 5307]

7
[ 125486-96-6 ]
[ 30383-01-8 ]
[ 895140-72-4 ]
[ 351209-70-6 ]

Yield	Reaction Conditions	Operation in experiment
75%	Stage #1: 2-(trimethylsilyl)ethanesulfonamide; (2R,3S,4R)-4-Benzyloxy-2-benzyloxymethyl-3-[(2S,3R,4S,5S,6R)-4,5-bis-benzyloxy-6-benzyloxymethyl-3-((2S,3S,4R,5R,6S)-3,4,5-tris-benzyloxy-6-methyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-2-yloxy]-3,4-dihydro-2H-pyran With iodonium(di-γ-collidine) perchlorate Stage #2: lithium thioethoxide In N,N-dimethyl-formamide at -40 - 0℃;

Reference： [1]Wang, Zhi-Guang; Zhang, Xufang; Visser, Michael; Live, David; Zatorski, Andrzej; Iserloh, Ulrich; Lloyd, Kenneth O.; Danishefsky, Samuel J. [Angewandte Chemie - International Edition, 2001, vol. 40, # 9, p. 1728 - 1732]

8
[ 100-42-5 ]
[ 125486-96-6 ]
[ 236122-14-8 ]

Yield	Reaction Conditions	Operation in experiment
97%	With tert-butylhypochlorite; sodium iodide In acetonitrile at 20℃; for 3h;
68%	With iodosylbenzene; 3 A molecular sieve In acetonitrile at 20℃; for 20h;

Reference： [1]Minakata, Satoshi; Morino, Yoshinobu; Oderaotoshi, Yoji; Komatsu, Mitsuo [Chemical Communications, 2006, # 31, p. 3337 - 3339]
[2]Dauban; Saniere; Tarrade; Dodd [Journal of the American Chemical Society, 2001, vol. 123, # 31, p. 7707 - 7708]

9
[ 498-66-8 ]
[ 125486-96-6 ]
3-(2-trimethylsilanyl-ethanesulfonyl)-3-aza-tricyclo[3.2.1.0^2,4]octane [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
63%	With iodosylbenzene; 3 A molecular sieve In acetonitrile at 20℃; for 20h;

Reference： [1]Dauban; Saniere; Tarrade; Dodd [Journal of the American Chemical Society, 2001, vol. 123, # 31, p. 7707 - 7708]

10
[ 6622-76-0 ]
[ 125486-96-6 ]
[ 359715-85-8 ]

Yield	Reaction Conditions	Operation in experiment
48%	With iodosylbenzene; 3 A molecular sieve In acetonitrile at 20℃; for 20h;

Reference： [1]Dauban; Saniere; Tarrade; Dodd [Journal of the American Chemical Society, 2001, vol. 123, # 31, p. 7707 - 7708]

11
[ 125486-96-6 ]
[ 103-26-4 ]
[ 359715-80-3 ]

Yield	Reaction Conditions	Operation in experiment
53%	With iodosylbenzene; 3 A molecular sieve In acetonitrile at 20℃; for 20h;

Reference： [1]Dauban; Saniere; Tarrade; Dodd [Journal of the American Chemical Society, 2001, vol. 123, # 31, p. 7707 - 7708]

12
[ 125486-96-6 ]
[ 80-62-6 ]
N-(2-(trimethylsilyl)ethanesulfonyl)-2-(methoxycarbonyl)-2-methylaziridine [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
43%	With iodosylbenzene; 3 A molecular sieve In acetonitrile at 20℃; for 20h;

Reference： [1]Dauban; Saniere; Tarrade; Dodd [Journal of the American Chemical Society, 2001, vol. 123, # 31, p. 7707 - 7708]

13
[ 125486-96-6 ]
[ 110-83-8 ]
N-(2-(trimethylsilyl)ethanesulfonyl)-7-azabicyclo<4.1.0>heptane [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
46%	With iodosylbenzene; 3 A molecular sieve In acetonitrile at 20℃; for 20h;

Reference： [1]Dauban; Saniere; Tarrade; Dodd [Journal of the American Chemical Society, 2001, vol. 123, # 31, p. 7707 - 7708]

14
[ 498-60-2 ]
[ 125486-96-6 ]
N-1[(E)-(3-furyl)methylidene]-2-(trimethylsilyl)-1-ethanesulfonamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
69%	With boron trifluoride diethyl etherate In toluene for 3h; Heating;

Reference： [1]Aggarwal, Varinder K.; Vasse, Jean-Luc [Organic Letters, 2003, vol. 5, # 21, p. 3987 - 3990]

15
[ 5414-21-1 ]
[ 125486-96-6 ]
[ 652130-73-9 ]

Yield	Reaction Conditions	Operation in experiment
76%	With caesium carbonate In N,N-dimethyl-formamide at 20℃;

Reference： [1]Parker, Laurie L.; Gowans, Nicholas D.; Jones, Stephen W.; Robins, David J. [Tetrahedron, 2003, vol. 59, # 51, p. 10165 - 10171]

16
[ 6621-59-6 ]
[ 125486-96-6 ]
[ 652130-74-0 ]

Yield	Reaction Conditions	Operation in experiment
73%	With caesium carbonate In N,N-dimethyl-formamide at 20℃;

Reference： [1]Parker, Laurie L.; Gowans, Nicholas D.; Jones, Stephen W.; Robins, David J. [Tetrahedron, 2003, vol. 59, # 51, p. 10165 - 10171]

17
[ 106018-85-3 ]
[ 125486-96-6 ]

Yield	Reaction Conditions	Operation in experiment
88%	With ammonia In dichloromethane at 0℃; for 2h;
75%	With ammonium hydroxide In water; acetonitrile at 0 - 20℃;
31%	With ethanol; ammonia In dichloromethane at 0℃;

Reference： [1]Parker, Laurie L.; Gowans, Nicholas D.; Jones, Stephen W.; Robins, David J. [Tetrahedron, 2003, vol. 59, # 51, p. 10165 - 10171]
[2]Benohoud, Meryem; Leman, Loic; Cardoso, Silvia H.; Retailleau, Pascal; Dauban, Philippe; Thierry, Josiane; Dodd, Robert H. [Journal of Organic Chemistry, 2009, vol. 74, # 15, p. 5331 - 5336]
[3]Aggarwal; Ferrara; O'Brien; Thompson; Jones; Fieldhouse [Journal of the Chemical Society. Perkin Transactions 1 (2001), 2001, # 14, p. 1635 - 1643]

18
[ 500-22-1 ]
[ 125486-96-6 ]
[ 292638-85-8 ]
methyl 2-(pyridin-3-yl(2-(trimethylsilyl)ethylsulfonamido)methyl)acrylate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
79%	With titanium(IV) isopropylate; molecular sieve; 3-quinuclidinol In isopropyl alcohol at 70℃; for 6h;

Reference： [1]Declerck, Valerie; Ribiere, Patrice; Martinez, Jean; Lamaty, Fredereric [Journal of Organic Chemistry, 2004, vol. 69, # 24, p. 8372 - 8381]

19
[ 98-01-1 ]
[ 125486-96-6 ]
[ 292638-85-8 ]
methyl 2-(furan-2-yl(2-(trimethylsilyl)ethylsulfonamido)methyl)acrylate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
71%	With 1,4-diaza-bicyclo[2.2.2]octane In isopropyl alcohol at 70℃; for 6h;

Reference： [1]Declerck, Valerie; Ribiere, Patrice; Martinez, Jean; Lamaty, Fredereric [Journal of Organic Chemistry, 2004, vol. 69, # 24, p. 8372 - 8381]

20
[ 7797-83-3 ]
[ 125486-96-6 ]
[ 292638-85-8 ]
[ 816457-70-2 ]

Yield	Reaction Conditions	Operation in experiment
66%	With 1,4-diaza-bicyclo[2.2.2]octane In isopropyl alcohol at 70℃; for 72h;

Reference： [1]Declerck, Valerie; Ribiere, Patrice; Martinez, Jean; Lamaty, Fredereric [Journal of Organic Chemistry, 2004, vol. 69, # 24, p. 8372 - 8381]

21
[ 125486-96-6 ]
[ 104-88-1 ]
[ 292638-85-8 ]
[ 816457-71-3 ]

Yield	Reaction Conditions	Operation in experiment
86%	With 1,4-diaza-bicyclo[2.2.2]octane In isopropyl alcohol at 70℃; for 14h;

Reference： [1]Declerck, Valerie; Ribiere, Patrice; Martinez, Jean; Lamaty, Fredereric [Journal of Organic Chemistry, 2004, vol. 69, # 24, p. 8372 - 8381]

22
[ 125486-96-6 ]
[ 555-16-8 ]
[ 292638-85-8 ]
[ 816457-74-6 ]

Yield	Reaction Conditions	Operation in experiment
60%	With 1,4-diaza-bicyclo[2.2.2]octane In isopropyl alcohol at 70℃; for 6h;

Reference： [1]Declerck, Valerie; Ribiere, Patrice; Martinez, Jean; Lamaty, Fredereric [Journal of Organic Chemistry, 2004, vol. 69, # 24, p. 8372 - 8381]

23
[ 18143-40-3 ]
[ 125486-96-6 ]

Yield	Reaction Conditions	Operation in experiment
67%	Stage #1: sodium β-trimethylsilylethanesulfonate With phosphorus pentachloride In dichloromethane at 20℃; for 0.5h; Stage #2: With ammonia In dichloromethane at -10℃; for 0.25h;

Reference： [1]Declerck, Valerie; Ribiere, Patrice; Martinez, Jean; Lamaty, Fredereric [Journal of Organic Chemistry, 2004, vol. 69, # 24, p. 8372 - 8381]

24
[ 125486-96-6 ]
[ 100-52-7 ]
[ 292638-85-8 ]
[ 816457-61-1 ]

Yield	Reaction Conditions	Operation in experiment
86%	With 1,4-diaza-bicyclo[2.2.2]octane In isopropyl alcohol at 70℃; for 10h;

Reference： [1]Declerck, Valerie; Ribiere, Patrice; Martinez, Jean; Lamaty, Fredereric [Journal of Organic Chemistry, 2004, vol. 69, # 24, p. 8372 - 8381]
[2]Ribière, Patrice; Declerck, Valérie; Nédellec, Yannig; Yadav-Bhatnagar, Neerja; Martinez, Jean; Lamaty, Frédéric [Tetrahedron, 2006, vol. 62, # 44, p. 10456 - 10466]
[3]Declerck, Valerie; Allouchi, Hassan; Martinez, Jean; Lamaty, Frederic [Journal of Organic Chemistry, 2007, vol. 72, # 4, p. 1518 - 1521]

25
[ 125486-96-6 ]
[ 66-99-9 ]
[ 292638-85-8 ]
[ 816457-67-7 ]

Yield	Reaction Conditions	Operation in experiment
60%	With 1,4-diaza-bicyclo[2.2.2]octane In isopropyl alcohol at 70℃; for 48h;

Reference： [1]Declerck, Valerie; Ribiere, Patrice; Martinez, Jean; Lamaty, Fredereric [Journal of Organic Chemistry, 2004, vol. 69, # 24, p. 8372 - 8381]
[2]Declerck, Valerie; Allouchi, Hassan; Martinez, Jean; Lamaty, Frederic [Journal of Organic Chemistry, 2007, vol. 72, # 4, p. 1518 - 1521]

26
[ 26260-02-6 ]
[ 125486-96-6 ]
[ 292638-85-8 ]
[ 816457-72-4 ]

Yield	Reaction Conditions	Operation in experiment
73%	With 1,4-diaza-bicyclo[2.2.2]octane In isopropyl alcohol at 70℃; for 10h;

Reference： [1]Declerck, Valerie; Ribiere, Patrice; Martinez, Jean; Lamaty, Fredereric [Journal of Organic Chemistry, 2004, vol. 69, # 24, p. 8372 - 8381]
[2]Declerck, Valerie; Allouchi, Hassan; Martinez, Jean; Lamaty, Frederic [Journal of Organic Chemistry, 2007, vol. 72, # 4, p. 1518 - 1521]

27
[ 5779-95-3 ]
[ 125486-96-6 ]
[ 292638-85-8 ]
[ 816457-69-9 ]

Yield	Reaction Conditions	Operation in experiment
70%	With 1,4-diaza-bicyclo[2.2.2]octane In isopropyl alcohol at 70℃; for 72h;

Reference： [1]Declerck, Valerie; Ribiere, Patrice; Martinez, Jean; Lamaty, Fredereric [Journal of Organic Chemistry, 2004, vol. 69, # 24, p. 8372 - 8381]

28
[ 7311-34-4 ]
[ 125486-96-6 ]
[ 292638-85-8 ]
[ 816457-62-2 ]

Yield	Reaction Conditions	Operation in experiment
67%	With 1,4-diaza-bicyclo[2.2.2]octane In isopropyl alcohol at 70℃; for 72h;

Reference： [1]Declerck, Valerie; Ribiere, Patrice; Martinez, Jean; Lamaty, Fredereric [Journal of Organic Chemistry, 2004, vol. 69, # 24, p. 8372 - 8381]
[2]Ribière, Patrice; Declerck, Valérie; Nédellec, Yannig; Yadav-Bhatnagar, Neerja; Martinez, Jean; Lamaty, Frédéric [Tetrahedron, 2006, vol. 62, # 44, p. 10456 - 10466]
[3]Declerck, Valerie; Allouchi, Hassan; Martinez, Jean; Lamaty, Frederic [Journal of Organic Chemistry, 2007, vol. 72, # 4, p. 1518 - 1521]

29
[ 125486-96-6 ]
[ 77123-57-0 ]
[ 292638-85-8 ]
[ 816457-73-5 ]

Yield	Reaction Conditions	Operation in experiment
61%	With 1,4-diaza-bicyclo[2.2.2]octane In isopropyl alcohol at 70℃; for 14h;

Reference： [1]Declerck, Valerie; Ribiere, Patrice; Martinez, Jean; Lamaty, Fredereric [Journal of Organic Chemistry, 2004, vol. 69, # 24, p. 8372 - 8381]

30
[ 125486-96-6 ]
[ 292638-85-8 ]
[ 6630-33-7 ]
[ 816457-66-6 ]

Yield	Reaction Conditions	Operation in experiment
86%	With 1,4-diaza-bicyclo[2.2.2]octane In isopropyl alcohol at 70℃; for 6h;

Reference： [1]Declerck, Valerie; Ribiere, Patrice; Martinez, Jean; Lamaty, Fredereric [Journal of Organic Chemistry, 2004, vol. 69, # 24, p. 8372 - 8381]

31
[ 125486-96-6 ]
[ 292638-85-8 ]
[ 620-23-5 ]
[ 816457-68-8 ]

Yield	Reaction Conditions	Operation in experiment
86%	With 1,4-diaza-bicyclo[2.2.2]octane In isopropyl alcohol at 70℃; for 38h;

Reference： [1]Declerck, Valerie; Ribiere, Patrice; Martinez, Jean; Lamaty, Fredereric [Journal of Organic Chemistry, 2004, vol. 69, # 24, p. 8372 - 8381]

32
[ 125486-96-6 ]
[ 292638-85-8 ]
[ 1571-08-0 ]
[ 816457-63-3 ]

Yield	Reaction Conditions	Operation in experiment
90%	With 1,4-diaza-bicyclo[2.2.2]octane In isopropyl alcohol at 70℃; for 6h;

Reference： [1]Declerck, Valerie; Ribiere, Patrice; Martinez, Jean; Lamaty, Fredereric [Journal of Organic Chemistry, 2004, vol. 69, # 24, p. 8372 - 8381]

33
[ 125486-96-6 ]
[ 292638-85-8 ]
[ 456-48-4 ]
[ 816457-65-5 ]

Yield	Reaction Conditions	Operation in experiment
79%	With 1,4-diaza-bicyclo[2.2.2]octane In isopropyl alcohol at 70℃; for 6h;

Reference： [1]Declerck, Valerie; Ribiere, Patrice; Martinez, Jean; Lamaty, Fredereric [Journal of Organic Chemistry, 2004, vol. 69, # 24, p. 8372 - 8381]
[2]Declerck, Valerie; Allouchi, Hassan; Martinez, Jean; Lamaty, Frederic [Journal of Organic Chemistry, 2007, vol. 72, # 4, p. 1518 - 1521]

34
[ 24424-99-5 ]
[ 125486-96-6 ]
[ 145387-82-2 ]

Yield	Reaction Conditions	Operation in experiment
90%	With dmap; triethylamine In dichloromethane at 20℃;

Reference： [1]Masllorens, Judit; Moreno-Mañas, Marcial; Roglans, Anna [Tetrahedron, 2005, vol. 61, # 42, p. 10105 - 10112]

35
[ 1193-82-4 ]
[ 125486-96-6 ]
[ 452898-05-4 ]

Yield	Reaction Conditions	Operation in experiment
83%	With [bis(acetoxy)iodo]benzene; silver nitrate; 4,4',4-tri-tert-butyl-2,2':6',2-terpyridine In acetonitrile at 20℃; for 168h;
70%	With iron(II) triflate; iodosylbenzene In acetonitrile at 20℃; Molecular sieve;
66%	With iodosylbenzene In acetonitrile at 20℃; for 18h;

Reference： [1]Gae, Young Cho; Bolm, Carsten [Organic Letters, 2005, vol. 7, # 22, p. 4983 - 4985]
[2]Mancheno, Olga Garcia; Dallimore, Jonathan; Plant, Andrew; Bolm, Carsten [Organic Letters, 2009, vol. 11, # 11, p. 2429 - 2432]
[3]Mancheno, Olga Garcia; Bolm, Carsten [Organic Letters, 2006, vol. 8, # 11, p. 2349 - 2352]

36
[ 125486-96-6 ]
[ 132911-87-6 ]
2-Trimethylsilanyl-ethanesulfonic acid [(2S,3S,4R,5S,6R)-5-((2S,3R,4S,5S,6R)-4-allyloxy-3,5-bis-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yloxy)-4-benzyloxy-6-benzyloxymethyl-2-iodo-tetrahydro-pyran-3-yl]-amide [ No CAS ]
2-Trimethylsilanyl-ethanesulfonic acid [(2R,3R,4R,5S,6R)-5-((2S,3R,4S,5S,6R)-4-allyloxy-3,5-bis-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yloxy)-4-benzyloxy-6-benzyloxymethyl-2-iodo-tetrahydro-pyran-3-yl]-amide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
1: 75% 2: 12%	Stage #1: 2-(trimethylsilyl)ethanesulfonamide; 4-=-(3-O-allyl-2,4,6-tri-O-benzyl-β-D-galactopyranosyl)-3,6-di-O-benzyl-D-arabino-hex-1-enitol In dichloromethane at 20℃; for 0.5h; Stage #2: With Ag(collidine)2ClO₄; iodine In dichloromethane at 0℃; for 1.5h;

Reference： [1]Wang, Zhi-Guang; Warren, J. David; Dudkin, Vadim Y.; Zhang, Xufang; Iserloh, Ulrich; Visser, Michael; Eckhardt, Matthias; Seeberger, Peter H.; Danishefsky, Samuel J. [Tetrahedron, 2006, vol. 62, # 20, p. 4954 - 4978]

37
[ 125486-96-6 ]
[ 292638-85-8 ]
[ 105-07-7 ]
[ 929012-64-6 ]

Yield	Reaction Conditions	Operation in experiment
80%	With 1,4-diaza-bicyclo[2.2.2]octane In isopropyl alcohol at 70℃; for 6h;

Reference： [1]Declerck, Valerie; Allouchi, Hassan; Martinez, Jean; Lamaty, Frederic [Journal of Organic Chemistry, 2007, vol. 72, # 4, p. 1518 - 1521]

38
[ 125486-96-6 ]
[ 105-45-3 ]
C₁₀H₂₁NO₄SSi [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
93%	With toluene-4-sulfonic acid In benzene Heating;

Reference： [1]Li, Baoqing; Franck, Richard W.; Capozzi, Giuseppe; Menichetti, Stefano; Nativi, Cristina [Organic Letters, 1999, vol. 1, # 1, p. 111 - 113]

39
C₁₂H₂₀O₃ [ No CAS ]
[ 125486-96-6 ]
C₁₇H₃₃NO₄SSiH₂O [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
85%	With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 48h;

Reference： [1]Caldwell, John J.; Craig, Donald [Angewandte Chemie - International Edition, 2007, vol. 46, # 15, p. 2631 - 2634]

40
[ 125486-96-6 ]
[ 212071-06-2 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1: potassium carbonate / dimethylformamide 2: 2nd generation Grubbs catalyst / CH₂Cl₂
	Multi-step reaction with 3 steps 1: 86 percent / 1,4-diazabicyclo[2.2.2]octane / propan-2-ol / 10 h / 70 °C 2: 98 percent / K₂CO₃ / dimethylformamide / 6 h / 20 °C 3: 98 percent / Cl₂(PCyhex₃)(N₁,N₃-dimesyl-imidazol-2-yl)benzylidene Ru(VI) / CH₂Cl₂ / 5 h / 100 °C / microwave irradiation
	Multi-step reaction with 2 steps 1: 82 percent / BF₃*OEt₂ / benzene / 24 h / Heating 2: 96 percent / PPh₃ / benzene / Ambient temperature

Reference： [1]Declerck, Valerie; Allouchi, Hassan; Martinez, Jean; Lamaty, Frederic [Journal of Organic Chemistry, 2007, vol. 72, # 4, p. 1518 - 1521]
[2]Declerck, Valerie; Ribiere, Patrice; Martinez, Jean; Lamaty, Fredereric [Journal of Organic Chemistry, 2004, vol. 69, # 24, p. 8372 - 8381]
[3]Xu, Zhenrong; Lu, Xiyan [Journal of Organic Chemistry, 1998, vol. 63, # 15, p. 5031 - 5041]

41
[ 125486-96-6 ]
[ 223581-87-1 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: CHCl₃ / Heating 2: (R)-Tol-BINAPCuClO₄2MeCN / tetrahydrofuran / 24 h / 0 - 20 °C
	Multi-step reaction with 2 steps 1: 93 percent / CHCl₃ / Heating 2: 78 percent / (R)Tol-BINAP; CuClO₄*(CH₃CN)2 / CH₂Cl₂

Reference： [1]Ferraris; Young; Cox; Dudding; Drury III; Ryzhkov; Taggi; Lectka [Journal of the American Chemical Society, 2002, vol. 124, # 1, p. 67 - 77]
[2]Ferraris, Dana; Young, Brandon; Dudding, Travis; Drury III, William J.; Lectka, Thomas [Tetrahedron, 1999, vol. 55, # 29, p. 8869 - 8882]

42
1-(p-methoxyphenyl)ethyl acetate [ No CAS ]
[ 125486-96-6 ]
[ 1025359-75-4 ]

Yield	Reaction Conditions	Operation in experiment
78%	With t-BuOOAc In 1,2-dichloro-ethane at 25℃; for 6h;

Reference： [1]Powell, David A.; Pelletier, Guillaume [Tetrahedron Letters, 2008, vol. 49, # 16, p. 2495 - 2498]

43
[ 129825-11-2 ]
[ 125486-96-6 ]
[ 1045771-63-8 ]

Yield	Reaction Conditions	Operation in experiment
84%	With caesium carbonate In 1,4-dioxane at 120℃; for 15h;

Reference： [1]Anjanappa, Prakash; Mullick, Dibakar; Selvakumar, Kumaravel; Sivakumar, Manickam [Tetrahedron Letters, 2008, vol. 49, # 31, p. 4585 - 4587]

44
[ 109-09-1 ]
[ 125486-96-6 ]
[ 1045771-58-1 ]

Yield	Reaction Conditions	Operation in experiment
67%	With caesium carbonate In 1,4-dioxane at 120℃; for 15h;

Reference： [1]Anjanappa, Prakash; Mullick, Dibakar; Selvakumar, Kumaravel; Sivakumar, Manickam [Tetrahedron Letters, 2008, vol. 49, # 31, p. 4585 - 4587]

45
[ 109-04-6 ]
[ 125486-96-6 ]
[ 1045771-58-1 ]

Yield	Reaction Conditions	Operation in experiment
85%	With caesium carbonate In 1,4-dioxane at 100℃; for 15h;

Reference： [1]Anjanappa, Prakash; Mullick, Dibakar; Selvakumar, Kumaravel; Sivakumar, Manickam [Tetrahedron Letters, 2008, vol. 49, # 31, p. 4585 - 4587]

46
[ 1722-12-9 ]
[ 125486-96-6 ]
[ 1045771-69-4 ]

Yield	Reaction Conditions	Operation in experiment
90%	With caesium carbonate In 1,4-dioxane at 120℃; for 15h;

Reference： [1]Anjanappa, Prakash; Mullick, Dibakar; Selvakumar, Kumaravel; Sivakumar, Manickam [Tetrahedron Letters, 2008, vol. 49, # 31, p. 4585 - 4587]

47
[ 18368-76-8 ]
[ 125486-96-6 ]
[ 1045771-67-2 ]

Reference： [1]Tetrahedron Letters,2008,vol. 49,p. 4585 - 4587

48
[ 33252-30-1 ]
[ 125486-96-6 ]
[ 1045771-68-3 ]

Yield	Reaction Conditions	Operation in experiment
80%	With caesium carbonate In 1,4-dioxane at 120℃; for 15h;

Reference： [1]Anjanappa, Prakash; Mullick, Dibakar; Selvakumar, Kumaravel; Sivakumar, Manickam [Tetrahedron Letters, 2008, vol. 49, # 31, p. 4585 - 4587]

49
[ 39856-50-3 ]
[ 125486-96-6 ]
[ 1045771-57-0 ]

Yield	Reaction Conditions	Operation in experiment
85%	With caesium carbonate In 1,4-dioxane at 100℃; for 15h;

Reference： [1]Anjanappa, Prakash; Mullick, Dibakar; Selvakumar, Kumaravel; Sivakumar, Manickam [Tetrahedron Letters, 2008, vol. 49, # 31, p. 4585 - 4587]

50
[ 108-86-1 ]
[ 125486-96-6 ]
[ 1045771-47-8 ]

Yield	Reaction Conditions	Operation in experiment
85%	With caesium carbonate In 1,4-dioxane at 100℃; for 15h;

Reference： [1]Anjanappa, Prakash; Mullick, Dibakar; Selvakumar, Kumaravel; Sivakumar, Manickam [Tetrahedron Letters, 2008, vol. 49, # 31, p. 4585 - 4587]

51
[ 83-42-1 ]
[ 125486-96-6 ]
[ 1045771-66-1 ]

Reference： [1]Tetrahedron Letters,2008,vol. 49,p. 4585 - 4587

52
[ 1126-46-1 ]
[ 125486-96-6 ]
[ 1045771-60-5 ]

Yield	Reaction Conditions	Operation in experiment
90%	With caesium carbonate In 1,4-dioxane at 120℃; for 15h;

Reference： [1]Anjanappa, Prakash; Mullick, Dibakar; Selvakumar, Kumaravel; Sivakumar, Manickam [Tetrahedron Letters, 2008, vol. 49, # 31, p. 4585 - 4587]

53
[ 939-80-0 ]
[ 125486-96-6 ]
[ 1045771-61-6 ]

Reference： [1]Tetrahedron Letters,2008,vol. 49,p. 4585 - 4587

54
[ 5465-65-6 ]
[ 125486-96-6 ]
[ 1045771-62-7 ]

Yield	Reaction Conditions	Operation in experiment
89%	With caesium carbonate In 1,4-dioxane at 120℃; for 15h;

Reference： [1]Anjanappa, Prakash; Mullick, Dibakar; Selvakumar, Kumaravel; Sivakumar, Manickam [Tetrahedron Letters, 2008, vol. 49, # 31, p. 4585 - 4587]

55
[ 16588-02-6 ]
[ 125486-96-6 ]
[ 1045771-64-9 ]

Reference： [1]Tetrahedron Letters,2008,vol. 49,p. 4585 - 4587

56
[ 6952-59-6 ]
[ 125486-96-6 ]
[ 1045771-50-3 ]

Yield	Reaction Conditions	Operation in experiment
88%	With caesium carbonate In 1,4-dioxane at 100℃; for 15h;

Reference： [1]Anjanappa, Prakash; Mullick, Dibakar; Selvakumar, Kumaravel; Sivakumar, Manickam [Tetrahedron Letters, 2008, vol. 49, # 31, p. 4585 - 4587]

57
[ 24398-88-7 ]
[ 125486-96-6 ]
[ 1045771-48-9 ]

Yield	Reaction Conditions	Operation in experiment
95%	With caesium carbonate In 1,4-dioxane at 100℃; for 15h;

Reference： [1]Anjanappa, Prakash; Mullick, Dibakar; Selvakumar, Kumaravel; Sivakumar, Manickam [Tetrahedron Letters, 2008, vol. 49, # 31, p. 4585 - 4587]

58
[ 5798-75-4 ]
[ 125486-96-6 ]
[ 1045771-43-4 ]

Yield	Reaction Conditions	Operation in experiment
98%	With caesium carbonate In 1,4-dioxane at 100℃; for 15h;

Reference： [1]Anjanappa, Prakash; Mullick, Dibakar; Selvakumar, Kumaravel; Sivakumar, Manickam [Tetrahedron Letters, 2008, vol. 49, # 31, p. 4585 - 4587]

59
[ 90-11-9 ]
[ 125486-96-6 ]
[ 1045771-56-9 ]

Yield	Reaction Conditions	Operation in experiment
82%	With caesium carbonate In 1,4-dioxane at 100℃; for 15h;

Reference： [1]Anjanappa, Prakash; Mullick, Dibakar; Selvakumar, Kumaravel; Sivakumar, Manickam [Tetrahedron Letters, 2008, vol. 49, # 31, p. 4585 - 4587]

60
[ 623-00-7 ]
[ 125486-96-6 ]
[ 1045771-46-7 ]

Yield	Reaction Conditions	Operation in experiment
91%	With caesium carbonate In 1,4-dioxane at 100℃; for 15h;

Reference： [1]Anjanappa, Prakash; Mullick, Dibakar; Selvakumar, Kumaravel; Sivakumar, Manickam [Tetrahedron Letters, 2008, vol. 49, # 31, p. 4585 - 4587]

61
[ 577-19-5 ]
[ 125486-96-6 ]
[ 1045771-53-6 ]

Yield	Reaction Conditions	Operation in experiment
85%	With caesium carbonate In 1,4-dioxane at 100℃; for 15h;

Reference： [1]Anjanappa, Prakash; Mullick, Dibakar; Selvakumar, Kumaravel; Sivakumar, Manickam [Tetrahedron Letters, 2008, vol. 49, # 31, p. 4585 - 4587]

62
[ 402-43-7 ]
[ 125486-96-6 ]
[ 1045771-55-8 ]

Yield	Reaction Conditions	Operation in experiment
97%	With caesium carbonate In 1,4-dioxane at 100℃; for 15h;

Reference： [1]Anjanappa, Prakash; Mullick, Dibakar; Selvakumar, Kumaravel; Sivakumar, Manickam [Tetrahedron Letters, 2008, vol. 49, # 31, p. 4585 - 4587]

63
[ 69038-74-0 ]
[ 125486-96-6 ]
[ 1045771-49-0 ]

Reference： [1]Tetrahedron Letters,2008,vol. 49,p. 4585 - 4587

64
[ 67832-11-5 ]
[ 125486-96-6 ]
[ 1045771-54-7 ]

Yield	Reaction Conditions	Operation in experiment
91%	With caesium carbonate In 1,4-dioxane at 100℃; for 15h;

Reference： [1]Anjanappa, Prakash; Mullick, Dibakar; Selvakumar, Kumaravel; Sivakumar, Manickam [Tetrahedron Letters, 2008, vol. 49, # 31, p. 4585 - 4587]

65
[ 139102-34-4 ]
[ 125486-96-6 ]
[ 1045771-51-4 ]

Reference： [1]Tetrahedron Letters,2008,vol. 49,p. 4585 - 4587

66
[ 125486-96-6 ]
[ 104-88-1 ]
[ 1045771-44-5 ]

Yield	Reaction Conditions	Operation in experiment
88%	With caesium carbonate In 1,4-dioxane at 120℃; for 15h;

Reference： [1]Anjanappa, Prakash; Mullick, Dibakar; Selvakumar, Kumaravel; Sivakumar, Manickam [Tetrahedron Letters, 2008, vol. 49, # 31, p. 4585 - 4587]

67
[ 125486-96-6 ]
[ 99-91-2 ]
[ 1045771-59-2 ]

Yield	Reaction Conditions	Operation in experiment
92%	With caesium carbonate In 1,4-dioxane at 120℃; for 15h;

Reference： [1]Anjanappa, Prakash; Mullick, Dibakar; Selvakumar, Kumaravel; Sivakumar, Manickam [Tetrahedron Letters, 2008, vol. 49, # 31, p. 4585 - 4587]

68
[ 125486-96-6 ]
[ 105942-08-3 ]
[ 1045771-52-5 ]

Yield	Reaction Conditions	Operation in experiment
95%	With caesium carbonate In 1,4-dioxane at 100℃; for 15h;

Reference： [1]Anjanappa, Prakash; Mullick, Dibakar; Selvakumar, Kumaravel; Sivakumar, Manickam [Tetrahedron Letters, 2008, vol. 49, # 31, p. 4585 - 4587]

69
[ 125486-96-6 ]
[ 1122-91-4 ]
[ 1045771-44-5 ]

Yield	Reaction Conditions	Operation in experiment
90%	With caesium carbonate In 1,4-dioxane at 100℃; for 15h;

Reference： [1]Anjanappa, Prakash; Mullick, Dibakar; Selvakumar, Kumaravel; Sivakumar, Manickam [Tetrahedron Letters, 2008, vol. 49, # 31, p. 4585 - 4587]

70
[ 125486-96-6 ]
[ 6630-33-7 ]
[ 1045771-45-6 ]

Yield	Reaction Conditions	Operation in experiment
80%	With caesium carbonate In 1,4-dioxane at 100℃; for 15h;

Reference： [1]Anjanappa, Prakash; Mullick, Dibakar; Selvakumar, Kumaravel; Sivakumar, Manickam [Tetrahedron Letters, 2008, vol. 49, # 31, p. 4585 - 4587]

71
[ 125486-96-6 ]
[ 10298-80-3 ]
[ 1045771-65-0 ]

Yield	Reaction Conditions	Operation in experiment
74%	With caesium carbonate In 1,4-dioxane at 120℃; for 15h;

Reference： [1]Anjanappa, Prakash; Mullick, Dibakar; Selvakumar, Kumaravel; Sivakumar, Manickam [Tetrahedron Letters, 2008, vol. 49, # 31, p. 4585 - 4587]

72
[ 1041262-63-8 ]
[ 125486-96-6 ]
C₂₂H₂₈N₂O₆SSi [ No CAS ]
[ 1041262-65-0 ]

Yield	Reaction Conditions	Operation in experiment
	Stage #1: ethyl (5S)-5-(1,3-dioxoisoindolin-2-yl)-1-(phenylthio)cyclohex-3-enecarboxylate With sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid In toluene at 0℃; for 2h; Stage #2: With 1,8-diazabicyclo[5.4.0]undec-7-ene In toluene at 60℃; for 5h; Stage #3: 2-(trimethylsilyl)ethanesulfonamide With tetrakis(actonitrile)copper(I) hexafluorophosphate; iodosylbenzene; 3 A molecular sieve In acetonitrile at 20℃; Further stages. Title compound not separated from byproducts.;
	Stage #1: ethyl (5S)-5-(1,3-dioxoisoindolin-2-yl)-1-(phenylthio)cyclohex-3-enecarboxylate With sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid In toluene at 0℃; for 2h; Inert atmosphere; Stage #2: With 1,8-diazabicyclo[5.4.0]undec-7-ene In toluene at 60℃; for 5h; Inert atmosphere; Stage #3: 2-(trimethylsilyl)ethanesulfonamide With tetrakis(actonitrile)copper(I) hexafluorophosphate; iodosylbenzene In acetonitrile at 20℃; Inert atmosphere; Molecular sieve;

Reference： [1]Trost, Barry M.; Zhang, Ting [Angewandte Chemie - International Edition, 2008, vol. 47, # 20, p. 3759 - 3761]
[2]Location in patent: experimental part Trost, Barry M.; Zhang, Ting [Chemistry - A European Journal, 2011, vol. 17, # 13, p. 3630 - 3643]

73
[ 1041262-63-8 ]
[ 125486-96-6 ]
[ 1041262-65-0 ]

Yield	Reaction Conditions	Operation in experiment
86%	Stage #1: ethyl (5S)-5-(1,3-dioxoisoindolin-2-yl)-1-(phenylthio)cyclohex-3-enecarboxylate With sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid In toluene at 0℃; for 2h; Inert atmosphere; Stage #2: With 1,8-diazabicyclo[5.4.0]undec-7-ene In toluene at 60℃; for 5h; Inert atmosphere; Stage #3: 2-(trimethylsilyl)ethanesulfonamide With bis{rhodium[3,3'-(1,3-phenylene)bis(2,2-dimethylpropanoic acid)]; bis(tertbutylcarbonyloxy)iodobenzene; magnesium oxide In chlorobenzene at 0 - 20℃; Inert atmosphere;
206 mg	Stage #1: ethyl (5S)-5-(1,3-dioxoisoindolin-2-yl)-1-(phenylthio)cyclohex-3-enecarboxylate With sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid In toluene at 0℃; for 2h; Stage #2: With 1,8-diazabicyclo[5.4.0]undec-7-ene In toluene at 60℃; for 5h; Stage #3: 2-(trimethylsilyl)ethanesulfonamide With magnesium oxide In chlorobenzene at 0 - 20℃; Further stages.;

Reference： [1]Trost, Barry M.; Zhang, Ting [Chemistry - A European Journal, 2011, vol. 17, # 13, p. 3630 - 3643]
[2]Trost, Barry M.; Zhang, Ting [Angewandte Chemie - International Edition, 2008, vol. 47, # 20, p. 3759 - 3761]

74
[ 125486-96-6 ]
[ 100-51-6 ]
[ 106018-87-5 ]

Yield	Reaction Conditions	Operation in experiment
95%	With Ru/Fe₃O₄; potassium carbonate at 150℃; for 12h; Inert atmosphere;
94%	With air; copper diacetate; potassium carbonate at 150℃; for 12h;
94%	With copper diacetate; potassium carbonate at 150℃; for 12h;

87%

With [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂; potassium carbonate; triphenylphosphine In 5,5-dimethyl-1,3-cyclohexadiene at 150℃; for 24h; Inert atmosphere;

Reference： [1]Shi, Feng; Tse, Man Kin; Zhou, Shaolin; Pohl, Marga-Martina; Radnik, Joerg; et al. [Journal of the American Chemical Society, 2009, vol. 131, p. 1775 - 1779]
[2]Shi, Feng; Tse, Man Kin; Cui, Xinjiang; Goerdes, Dirk; Michalik, Dirk; Thurow, Kerstin; Deng, Youquan; Beller, Matthias [Angewandte Chemie - International Edition, 2009, vol. 48, # 32, p. 5912 - 5915]
[3]Location in patent: scheme or table Cui, Xinjiang; Shi, Feng; Tse, Man Kin; Goerdes, Dirk; Thurow, Kerstin; Beller, Matthias; Deng, Youquan [Advanced Synthesis and Catalysis, 2009, vol. 351, # 17, p. 2949 - 2958]
[4]Location in patent: experimental part Lamb, Gareth W.; Watson, Andrew J.A.; Jolley, Katherine E.; Maxwell, Aoife C.; Williams, Jonathan M.J. [Tetrahedron Letters, 2009, vol. 50, # 26, p. 3374 - 3377]

75
[ 125486-96-6 ]
[ 124754-47-8 ]
(4S)-4-[(1-[2-(trimethylsilyl)ethanesulfonyl]-2-aziridinyl)methyl]-1,3-oxazolidin-2-one [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
45%	With tetrakis(actonitrile)copper(I) hexafluorophosphate; iodosylbenzene In acetonitrile at 20℃; Molecular sieve; optical yield given as %de;

Reference： [1]Location in patent: experimental part Benohoud, Meryem; Leman, Loic; Cardoso, Silvia H.; Retailleau, Pascal; Dauban, Philippe; Thierry, Josiane; Dodd, Robert H. [Journal of Organic Chemistry, 2009, vol. 74, # 15, p. 5331 - 5336]

76
[ 500-22-1 ]
[ 125486-96-6 ]
[ 1232688-60-6 ]

Yield	Reaction Conditions	Operation in experiment
	With boron trifluoride diethyl etherate In toluene for 20h; Inert atmosphere; Reflux; Dean-Stark trap;	8.L.1 Step 1 Step 1 2-Trimethylsilyl-ethanesulfonic acid pyridin-3-ylmethyleneamide To a solution of 3-formylpyridine (0.228 mL, 2.42 mmol) and 2-(trimethylsilyl)ethanesulfonamide (0.438 g, 2.42 mmol) in toluene (30 mL) was added boron trifluoride etherate (0.02 mL, 0.15 mmol) under Ar. The mixture was heated at reflux for 20 hours using a Dean-Stark trap. After cooling, 10% aqueous sodium bicarbonate was added, and the mixture was extracted with ethyl acetate. The combined organic extracts were washed with brine, dried (Na2SO4), filtered and concentrated to dryness to under reduced pressure obtain crude 2-trimethylsilyl-ethanesulfonic acid pyridin-3-ylmethyleneamide (669 mg), which was used directly in the next step.

Reference： [1]Current Patent Assignee: ROCHE HOLDING AG - US2010/160388, 2010, A1 Location in patent: Page/Page column 62

77
[ 66236-13-3 ]
[ 125486-96-6 ]
[ 1251853-89-0 ]

Yield	Reaction Conditions	Operation in experiment
80%	With manganese(IV) oxide; 2,6-di-tert-butyl-4-methylpyridine; copper(II) 2-ethylhexanoate In α,α,α-trifluorotoluene at 20 - 110℃; for 24.3333h; Inert atmosphere; Molecular sieve;

Reference： [1]Sequeira, Fatima C.; Turnpenny, Benjamin W.; Chemler, Sherry R. [Angewandte Chemie - International Edition, 2010, vol. 49, # 36, p. 6365 - 6368]

78
[ 125486-96-6 ]
[ 642-31-9 ]
N-(9-anthrylmethylidene)-2-trimethylsilylethanesulfonamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
68%	With boron trifluoride diethyl etherate In toluene at 110℃; for 5h; Inert atmosphere; Dean-Stark separator;

Reference： [1]Location in patent: experimental part Dokli, Irena; Matanovic, Ivana; Hamersak, Zdenko [Chemistry - A European Journal, 2010, vol. 16, # 38, p. 11744 - 11752]

79
[ 100-13-0 ]
[ 125486-96-6 ]
[ 1276115-46-8 ]

Yield	Reaction Conditions	Operation in experiment
82%	Stage #1: 2-(trimethylsilyl)ethanesulfonamide With water; pivaloyl chloride; sodium hydroxide at 20℃; for 1h; Stage #2: 4-nitrostyrene With iodine at 20℃; for 1h;

Reference： [1]Minakata, Satoshi; Hayakawa, Junpei [Chemical Communications, 2011, vol. 47, # 6, p. 1905 - 1907]

80
[ 7642-09-3 ]
[ 125486-96-6 ]
(3R,4R)-3-iodo-4-(2-(trimethylsilyl)ethylsulfonamido)hexane [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
97%	Stage #1: 2-(trimethylsilyl)ethanesulfonamide With water; pivaloyl chloride; sodium hydroxide In dichloromethane at 20℃; for 1h; Stage #2: cis-3-hexene In dichloromethane at 20℃; for 1h;

Reference： [1]Minakata, Satoshi; Hayakawa, Junpei [Chemical Communications, 2011, vol. 47, # 6, p. 1905 - 1907]

81
[ 125486-96-6 ]
[ 140-88-5 ]
[ 1276115-48-0 ]

Yield	Reaction Conditions	Operation in experiment
73%	Stage #1: 2-(trimethylsilyl)ethanesulfonamide With water; pivaloyl chloride; sodium hydroxide at 20℃; for 1h; Stage #2: ethyl acrylate With iodine at 20℃; for 1h;

Reference： [1]Minakata, Satoshi; Hayakawa, Junpei [Chemical Communications, 2011, vol. 47, # 6, p. 1905 - 1907]

82
[ 1282041-44-4 ]
[ 125486-96-6 ]
[ 1282041-45-5 ]

Yield	Reaction Conditions	Operation in experiment
49%	With I(sym-coll)2ClO₄ In dichloromethane at 0℃; for 2h; Molecular sieve; Inert atmosphere; optical yield given as %ee; enantioselective reaction;

Reference： [1]Chaladaj, Wojciech; Jurczak, Janusz [European Journal of Organic Chemistry, 2011, # 7, p. 1223 - 1226]

83
[ 51450-24-9 ]
[ 125486-96-6 ]
[ 1293911-24-6 ]

Yield	Reaction Conditions	Operation in experiment
85%	With iodine In dichloromethane at -10℃; for 0.5h; Molecular sieve;

Reference： [1]Location in patent: experimental part Gautier, Franois-Moana; Djedaïni-Pilard, Florence; Grandjean, Cyrille [Carbohydrate Research, 2011, vol. 346, # 5, p. 577 - 587]

84
[ 51450-24-9 ]
[ 125486-96-6 ]
3,6-di-O-acetyl-1,2-dideoxy-2-iodo-4-O-(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl)-1-[2-(trimethylsilyl)ethanesulfonamido]-α-D-mannopyranose [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
65%	Stage #1: hexa-O-acetyl-D-lactal; 2-(trimethylsilyl)ethanesulfonamide With N-iodo-succinimide In dichloromethane at -10℃; for 2h; Molecular sieve; Stage #2: With iodine In dichloromethane at -10 - 5℃; Molecular sieve; diastereoselective reaction;

Reference： [1]Location in patent: experimental part Gautier, Franois-Moana; Djedaïni-Pilard, Florence; Grandjean, Cyrille [Carbohydrate Research, 2011, vol. 346, # 5, p. 577 - 587]

85
[ 51450-24-9 ]
[ 125486-96-6 ]
3,6-di-O-acetyl-1,2-dideoxy-2-iodo-4-O-(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl)-1-[2-(trimethylsilyl)ethanesulfonamido]-β-D-mannopyranose [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
50%	With Iodine monochloride In dichloromethane at -10℃; for 2.5h; Molecular sieve;

Reference： [1]Location in patent: experimental part Gautier, Franois-Moana; Djedaïni-Pilard, Florence; Grandjean, Cyrille [Carbohydrate Research, 2011, vol. 346, # 5, p. 577 - 587]

86
[ 13322-90-2 ]
[ 125486-96-6 ]
[ 1293911-34-8 ]

Reference： [1]Carbohydrate Research,2011,vol. 346,p. 577 - 587

87
[ 13322-90-2 ]
[ 125486-96-6 ]
[ 1293911-38-2 ]

Reference： [1]Carbohydrate Research,2011,vol. 346,p. 577 - 587

Purity	Size	Price	VIP Price	USA Stock *0-1 Day	Global Stock *5-7 Days	Quantity
{[ item.p_purity ]}	{[ item.pr_size ]}	{[ getRatePrice(item.pr_usd, 1,1) ]} {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]}	{[ getRatePrice(item.pr_usd, 1,1) ]}	Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_usd,1,item.mem_rate) ]}	{[ item.pr_usastock ]}	Inquiry -	{[ item.pr_chinastock ]}	Inquiry -

CAS No. :	125486-96-6	MDL No. :	MFCD09265152
Formula :	C₅H₁₅NO₂SSi	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	MZASHBBAFBWNFL-UHFFFAOYSA-N
M.W :	181.33	Pubchem ID :	11008553
Synonyms :

Num. heavy atoms :	10
Num. arom. heavy atoms :	0
Fraction Csp3 :	1.0
Num. rotatable bonds :	3
Num. H-bond acceptors :	3.0
Num. H-bond donors :	1.0
Molar Refractivity :	45.69
TPSA :	68.54 Å²

GI absorption :	High
BBB permeant :	Yes
P-gp substrate :	No
CYP1A2 inhibitor :	No
CYP2C19 inhibitor :	No
CYP2C9 inhibitor :	No
CYP2D6 inhibitor :	No
CYP3A4 inhibitor :	No
Log Kp (skin permeation) :	-6.61 cm/s

Log Po/w (iLOGP) :	0.89
Log Po/w (XLOGP3) :	1.12
Log Po/w (WLOGP) :	1.69
Log Po/w (MLOGP) :	-0.09
Log Po/w (SILICOS-IT) :	-1.51
Consensus Log Po/w :	0.42

[ CAS No. 125486-96-6 ] {[proInfo.proName]}

Quality Control of [ 125486-96-6 ]

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Calculated chemistry of [ 125486-96-6 ]

Physicochemical Properties

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Druglikeness

Water Solubility

Medicinal Chemistry

Safety of [ 125486-96-6 ]

Application In Synthesis of [ 125486-96-6 ]

[ 125486-96-6 ] Synthesis Path-Downstream 1~87

Precautionary Statements-General

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Disposal

Physical hazards

Health hazards

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Inquiry

Lipinski :	0.0
Ghose :	None
Veber :	0.0
Egan :	0.0
Muegge :	1.0
Bioavailability Score :	0.55

Log S (ESOL) :	-1.47
Solubility :	6.12 mg/ml ; 0.0337 mol/l
Class :	Very soluble
Log S (Ali) :	-2.15
Solubility :	1.28 mg/ml ; 0.00703 mol/l
Class :	Soluble
Log S (SILICOS-IT) :	-1.52
Solubility :	5.46 mg/ml ; 0.0301 mol/l
Class :	Soluble

PAINS :	0.0 alert
Brenk :	1.0 alert
Leadlikeness :	1.0
Synthetic accessibility :	3.13

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P261-P305+P351+P338	UN#:	N/A
Hazard Statements:	H302-H315-H319-H335	Packing Group:	N/A
GHS Pictogram:

Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling