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Chemical Structure| 1255207-11-4 Chemical Structure| 1255207-11-4

Structure of 1255207-11-4

Chemical Structure| 1255207-11-4

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Product Details of [ 1255207-11-4 ]

CAS No. :1255207-11-4
Formula : C10H8O3
M.W : 176.17
SMILES Code : O=CCC1=CC2=C(C=C1)C(OC2)=O
MDL No. :MFCD24678327

Safety of [ 1255207-11-4 ]

Application In Synthesis of [ 1255207-11-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1255207-11-4 ]

[ 1255207-11-4 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1255207-11-4 ]
  • [ 138007-24-6 ]
  • tert-butyl 1-(2-(1-oxo-1,3-dihydroisobenzofuran-5-yl)ethyl)piperidine-4-carboxylate [ No CAS ]
YieldReaction ConditionsOperation in experiment
With sodium tris(acetoxy)borohydride; In cis-1,2-Dichloroethylene; for 16h; tert-Butyl piperidine-4-carboxylate (2.84 g, 15.33 mmol) and 2-(1-oxo-1,3- dihydroisobenzofuran-5-yl)acetaldehyde(4.05 g, 22.99 mmol) were dissolved in DCE (120m1) then sodium triacetoxyborohydride (9.75 g, 46.0 mmol) was added and and the mixtue was stirred for 16 hrs. The reaction mixture was poured into aqueous NaHCO3 solution and extractedwith DCM. The organic layer was separated and dried over Na2504, filtered and concentrated. The crude residue was chromatographed through a 330g ISCO Redi-sep column and eluted with 5percent (NHOH: MeOH 1:9) in 95percent DCM to yield tert-butyl 1-(2-(1-oxo-1,3- dihydroisobenzofuran-5-yl)ethyl)piperidine-4-carboxylate. LC-MS (IE, m/z): 346 [M + 1]±; lHNMR (500 MHz, CDC13) oe ppm 7.859 (d, J= 7.9 Hz, 1H), 7.394 (d, J= 8.0 Hz, 1H), 7.352 (s,1H), 5.311 (s, 2H), 2.965 (b, 4H), 2.641 (b, 2H), 2.234 (b, 1H), 2.139 (b, 2H), 1.925(d, J 9.5 Hz, 2H), 1 .788( t, J 11.5 Hz, 2H,) 1.447 (s, 9H).
 

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