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[ CAS No. 1255207-11-4 ] {[proInfo.proName]}

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Chemical Structure| 1255207-11-4
Chemical Structure| 1255207-11-4
Structure of 1255207-11-4 * Storage: {[proInfo.prStorage]}
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Product Details of [ 1255207-11-4 ]

CAS No. :1255207-11-4 MDL No. :MFCD24678327
Formula : C10H8O3 Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 176.17 Pubchem ID :-
Synonyms :

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Application In Synthesis of [ 1255207-11-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1255207-11-4 ]

[ 1255207-11-4 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 1255207-11-4 ]
  • [ 138007-24-6 ]
  • tert-butyl 1-(2-(1-oxo-1,3-dihydroisobenzofuran-5-yl)ethyl)piperidine-4-carboxylate [ No CAS ]
YieldReaction ConditionsOperation in experiment
With sodium tris(acetoxy)borohydride; In cis-1,2-Dichloroethylene; for 16h; tert-Butyl piperidine-4-carboxylate (2.84 g, 15.33 mmol) and 2-(1-oxo-1,3- dihydroisobenzofuran-5-yl)acetaldehyde(4.05 g, 22.99 mmol) were dissolved in DCE (120m1) then sodium triacetoxyborohydride (9.75 g, 46.0 mmol) was added and and the mixtue was stirred for 16 hrs. The reaction mixture was poured into aqueous NaHCO3 solution and extractedwith DCM. The organic layer was separated and dried over Na2504, filtered and concentrated. The crude residue was chromatographed through a 330g ISCO Redi-sep column and eluted with 5percent (NHOH: MeOH 1:9) in 95percent DCM to yield tert-butyl 1-(2-(1-oxo-1,3- dihydroisobenzofuran-5-yl)ethyl)piperidine-4-carboxylate. LC-MS (IE, m/z): 346 [M + 1]±; lHNMR (500 MHz, CDC13) oe ppm 7.859 (d, J= 7.9 Hz, 1H), 7.394 (d, J= 8.0 Hz, 1H), 7.352 (s,1H), 5.311 (s, 2H), 2.965 (b, 4H), 2.641 (b, 2H), 2.234 (b, 1H), 2.139 (b, 2H), 1.925(d, J 9.5 Hz, 2H), 1 .788( t, J 11.5 Hz, 2H,) 1.447 (s, 9H).
  • 2
  • [ 1255207-11-4 ]
  • [ 886779-69-7 ]
  • tert-butyl 4-[2-(1-oxo-1,3-dihydro-2-benzofuran-5-yl)ethyl]-3-(trifluoromethyl)piperazine-1-carboxylate [ No CAS ]
YieldReaction ConditionsOperation in experiment
With sodium cyanoborohydride; In methanol; at 0 - 20℃; for 12.0h; To a solution of (1-oxo-1,3-dihydro-2-benzofuran-5-yl)acetaldehyde (0.495 g, 2.8 mmol) and <strong>[886779-69-7]tert-butyl 3-(trifluoromethyl)piperazine-1-carboxylate</strong> (0.65 g, 2.6 mmol) in methanol (5 ml) at 0 C was added sodium cyanoborohydride (0.21 g, 3.3 mmol) and the reaction stirred 12 hours at RT. The reaction mixture was concentrated and diluted with water. The aqueous was extracted with dichloromethane and the combined organics washed with brine, dried (MgSO4), filtered and concentrated. MPLC chromatography (2 ? 20% EtOAc:hexane) provided tert-butyl 4-[2-(1-oxo-1,3-dihydro-2-benzofuran-5-yl)ethyl]-3-(trifluoromethyl)piperazine-1-carboxylate. LC-MS (IE, m/z): 415.1 [M + 1]+.
  • 3
  • [ 226942-29-6 ]
  • [ 1255207-11-4 ]
  • 5-(2-(6-bromo-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)isobenzofuran-1(3H)-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
73.5% With sodium tris(acetoxy)borohydride; In dichloromethane; at 20℃; for 14h; To a solution of <strong>[226942-29-6]6-bromo-1,2,3,4-tetrahydroisoquinoline</strong> (0.700 g, 3.30 mmol) in DCM (30 mL) was added Intermediate 1-13 (0.640 g, 3.63 mmol) followed by sodium triacetoxyborohydride (1.40 g, 6.60 mmol). The resulting reaction mixture was stirred at ambient temperature for 14 h. The reaction mixture was diluted by water (50 mL) and extracted with DCM (2 x 50 mL). The combined extracts were washed with brine (50mL), dried over anhydrous sodium sulfate and concentrated. The crude was washed withdiethyl ether (2 x 50 mL) to afford Intermediate 6A (1.05 g, 73.5 %) as a brown solid. ?HNIVIR (400 MHz, DMSO-d6) ppm 2.70-2.80 (m, 6 H), 2.99 (t, J= 10 Hz, 2 H), 3.59 (s, 2H), 5.37 (s, 2 H), 7.03 (d, J= 10.8 Hz, 1 H), 7.27 (d, J= 2.4 Hz, 1 H), 7.31 (s, 1 H), 7.50(d, J= 10.4 Hz, 1 H), 7.56 (s, 1 H), 7.76 (d, J= 10.4 Hz, 1 H). LCMS (MethodR):retention time 1.03 mi (M+H) 374.2.
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