Home Cart Sign in  
Chemical Structure| 1256481-05-6 Chemical Structure| 1256481-05-6

Structure of 1256481-05-6

Chemical Structure| 1256481-05-6

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of [ 1256481-05-6 ]

CAS No. :1256481-05-6
Formula : C9H5F5O2
M.W : 240.13
SMILES Code : FC(F)(F)C(C1=CC(F)=C(OC)C(F)=C1)=O
MDL No. :MFCD11556177

Safety of [ 1256481-05-6 ]

Application In Synthesis of [ 1256481-05-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1256481-05-6 ]

[ 1256481-05-6 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 104197-14-0 ]
  • [ 1256481-05-6 ]
YieldReaction ConditionsOperation in experiment
With hydrogenchloride; In tetrahydrofuran; Example 136 Preparation of 1-(3,5-Difluoro-4-methoxyphenyl)-2,2,2-trifluoroethanone Isopropyl magnesium chloride lithium chloride complex (22.0 mL, 28.02 mmol) was added dropwise to a stirred solution of <strong>[104197-14-0]5-bromo-1,3-difluoro-2-methoxybenzene</strong> (5.0 g, 22.42 mmol) at -5 C. in THF (100 mL) and the reaction mixture was stirred at same temperature for 30 min. Methyl triflouroacetate (3.67 g, 28.69 mmol) was added dropwise and then the reaction mixture was stirred at ambient temperature for 2 h. A 2 N HCl solution (200 mL) was added to quench the reaction and then it was extracted with diethylether. The organic combinded layers were washed with brine dried (Na2SO4), filtered and concentrated to afford the title compound (5.4 g, crude) as a yellow liquid. The material was taken on to next step without further purification. 1H NMR (400 MHz, CDCl3) delta 7.68-7.60 (m, 2H), 4.19 (s, 3H); ESIMS m/z 240.1 ([M]+).
 

Historical Records

Technical Information

Categories