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Chemical Structure| 1256579-62-0 Chemical Structure| 1256579-62-0

Structure of 1256579-62-0

Chemical Structure| 1256579-62-0

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Product Details of [ 1256579-62-0 ]

CAS No. :1256579-62-0
Formula : C28H29BrN4O2
M.W : 533.46
SMILES Code : N#CC1=CC2=C(C=C1)C3=C(C(C)(C)C4=CC(N5CCC(N6CCOCC6)CC5)=C(Br)C=C4C3=O)N2
MDL No. :MFCD28098313

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Application In Synthesis of [ 1256579-62-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1256579-62-0 ]

[ 1256579-62-0 ] Synthesis Path-Downstream   1~2

  • 2
  • [ 1256579-62-0 ]
  • [ 557-20-0 ]
  • [ 1256580-46-7 ]
YieldReaction ConditionsOperation in experiment
80.14% With palladium diacetate; tricyclohexylphosphine; In N,N-dimethyl acetamide; toluene; at 40 - 45℃; To a solution of 9-bromo-6,6-dimethyl-8-(4-morpholinopiperidin- l -yl)- l l -oxo-6, 1 1 - dihydro-5H-benzo-[b]carbazole-3-carbonitrile (2.0 g) in dimethylacetamide (20 ml), palladium acetate (0.08 g) and tricyclohexylphosphine (0.21 g) was added. The reaction mixture was stirred for 10- 1 5 minutes at ambient temperature followed by addition of diethyl zinc (1 5%w/w solution in toluene, 6.8 ml). The reaction mixture was stirred for 2-3 hours at 40-45 C and then cooled to room temperature followed by quenching with a mixture of hydrochloric acid (0.7 ml) and water (40 ml). The resulting product was filtered and dried at 50-55 C for 1 0- 1 2 hours. Solid thus obtained product was dissolved in methanol: dichloromethane (1 :3, 40 ml), treated with activated carbon and filtered through Celite. The filtrate was distilled at atmospheric pressure and cooled to 0-5 C. The solid was filtered, washed with pre- cooled (0-5 C) methanol (5.0 ml) and dried under vacuum at 50-55 C for 10- 1 2 hours to give 1 .45 g (80.14%) of Alectinib.
 

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