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CAS No. : | 1256818-14-0 | MDL No. : | MFCD18256212 |
Formula : | C7H5F2NO2 | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | XBLKYGVQHXXTDM-UHFFFAOYSA-N |
M.W : | 173.12 | Pubchem ID : | 58516113 |
Synonyms : |
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Signal Word: | Warning | Class: | N/A |
Precautionary Statements: | P261-P280-P301+P312-P302+P352-P305+P351+P338 | UN#: | N/A |
Hazard Statements: | H302-H315-H319-H335 | Packing Group: | N/A |
GHS Pictogram: |
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* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
400 mg | With water; sodium hydroxide In methanol at 20℃; | 130 Description 1302-(Difluoromethyl)isonicotinic acid (D130) Description 1302-(Difluoromethyl)isonicotinic acid (D130)NF(iy0HF 0A mixture of methyl 2-(difluoromethyl)isonicotinate (D129, 500 mg), NaOH (1069 mg) in water (10 mL) and MeOH (10 mL) was stirred at RT overnight. The mixture was concentrated and adjusted to pH < 7 with 2 M HC1, then extracted with EtOAc (3 x50 mL). The organic layer was washed with saturated NaHCO3 solution (10 mL), water (10 mL), and brine (10 mL), dried over MgSO4, filtered and concentrated to afford the title compound (400 mg) as white solid. MS (ESI):C7H5F2N02 requires 173; found 174 [M+H]. |