Alternatived Products of [ 1256823-49-0 ]
Product Details of [ 1256823-49-0 ]
CAS No. : | 1256823-49-0 |
MDL No. : | MFCD17014981 |
Formula : |
C7H8BrNO
|
Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | - |
M.W : |
202.05
|
Pubchem ID : | - |
Synonyms : |
|
Safety of [ 1256823-49-0 ]
Application In Synthesis of [ 1256823-49-0 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 1256823-49-0 ]
- 1
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[ 186593-45-3 ]
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[ 74-88-4 ]
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[ 1256823-49-0 ]
Yield | Reaction Conditions | Operation in experiment |
47% |
With potassium carbonate In N,N-dimethyl-formamide at 20℃; |
15.I Part I - Synthesis of 3 -Bromo-5-methoxy-2-methylpyridine
Into a 100-mL round-bottom flask, was placed a solution of 5-bromo-6-methylpyridin-3-ol (3 g, 16 mmol) in N.N-dimethylformamide (30 mL). Potassium carbonate (3.3 g, 24 mmol) was added, followed by iodomethane (3.4 g, 24 mmol). The mixture was stirred at room temperature overnight then diluted with ethyl acetate (100 mL), washed with water (3 x 100 mL), dried over anhydrous sodium sulfate, and concentrated. The residue was purified on a silica gel column eluting with petroleum ether/ethyl acetate (4: 1) to yield 3- bromo-5-methoxy-2-methylpyridine (1.5 g, 47%). |