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Chemical Structure| 1256824-49-3 Chemical Structure| 1256824-49-3

Structure of 1256824-49-3

Chemical Structure| 1256824-49-3

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Product Details of [ 1256824-49-3 ]

CAS No. :1256824-49-3
Formula : C6H6BrNO
M.W : 188.02
SMILES Code : OC1=C(C)C=C(Br)N=C1
MDL No. :MFCD18255424

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Application In Synthesis of [ 1256824-49-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1256824-49-3 ]

[ 1256824-49-3 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 156118-16-0 ]
  • [ 1256824-49-3 ]
YieldReaction ConditionsOperation in experiment
52% With sulfuric acid; sodium nitrite; In water; at 0 - 20℃; for 24.5h; To a stirred solution of 6-bromo-4- methylpyridin-3 -amine (2.0 g, 10.7 mmol) in aqueous 40% sulfuric acid (20 mL) was added sodium nitrite (1.1 g, 16.1 mmol) at 0 C. The resulting mixture was stirred for 30 min at 0 C and 24 hours at ambient temperature. The resulting mixture was diluted with water (200 mL) and neutralized by potassium carbonate. The resulting mixture was extracted with ethyl acetate (3 x 100 mL). The combined organic layers was washed with brine (2 x 100 mL) and dried over anhydrous sodium sulfate. After filtration, the filtrate was concentrated under reduced pressure and the residue was purified by silica gel column chromatography, eluted with 0.5-1.5% methanol in dichloromethane to afford 6-bromo-4-methylpyridin-3-ol as a light yellow solid: MS (ESI, m/z): 188.0, 190.0 [M + 1]+; 1H MR (300 MHz, OMSO-d6) delta 7.89 (s, 1H), 7.83 (s, 1H), 7.35 (s, 1H), 2.13 (s, 3H).
 

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