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Chemical Structure| 1256944-93-0 Chemical Structure| 1256944-93-0

Structure of 1256944-93-0

Chemical Structure| 1256944-93-0

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Product Details of [ 1256944-93-0 ]

CAS No. :1256944-93-0
Formula : C13H16BF3O3
M.W : 288.07
SMILES Code : OC1=CC(C(F)(F)F)=CC(B2OC(C)(C)C(C)(C)O2)=C1
MDL No. :MFCD16994399

Safety of [ 1256944-93-0 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 1256944-93-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1256944-93-0 ]

[ 1256944-93-0 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1025718-84-6 ]
  • [ 73183-34-3 ]
  • [ 1256944-93-0 ]
YieldReaction ConditionsOperation in experiment
40% With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; In 1,4-dioxane; at 80℃; for 2.0h;Inert atmosphere; [00530] Synthesis of 3-(4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2-yl)-5- (trifluoromethyl)phenol (182): 3-Bromo-5-(trifluoromethyl)phenol (181; 2.5 g, 10 mmol), 4j4;4'j4';5;5,5';5'.0ctamethyl-2,2'-bi(l,3,2-dioxaborolane) (3.8 g, 15 mmol), Pd(dppf)Cl2 (1.1 g, 1.5 mmol), and potassium acetate (2 g, 20 mmol) were added in 50 mL of dioxane and degassed. The reaction mixture was heated at 80 C under nitrogen atmosphere for 2 h. After cooling down to room temperature, the reaction mixture was filtered. The filtrate was concentrated under reduced pressure to give the crude product, which was purified by silica gel chromatography (10% EtO Ac/petroleum ether) to yield 1.2 g of 3-(4,4,5,5-tetramethyl- l,3,2-dioxaborolan-2-yl)-5-(trifluoromethyl)phenol (182) as white solid (40% yield). LCMS: m/z 289.1 , = 1.77 min.
 

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