Home Cart Sign in  
Chemical Structure| 1257293-79-0 Chemical Structure| 1257293-79-0

Structure of 1257293-79-0

Chemical Structure| 1257293-79-0

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of [ 1257293-79-0 ]

CAS No. :1257293-79-0
Formula : C11H21NO3
M.W : 215.29
SMILES Code : O=C(N1CC(C(C)(O)C)C1)OC(C)(C)C
MDL No. :MFCD22370133
InChI Key :GMOIZAKBLSIACP-UHFFFAOYSA-N
Pubchem ID :59605306

Safety of [ 1257293-79-0 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P280-P301+P312-P302+P352-P305+P351+P338

Application In Synthesis of [ 1257293-79-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1257293-79-0 ]

[ 1257293-79-0 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 610791-05-4 ]
  • [ 1257293-79-0 ]
YieldReaction ConditionsOperation in experiment
96% With methyl magnesium iodide; In tetrahydrofuran; at 20℃; Step A: tert-Butyl 3-(2-hydroxypropan-2-yl)azetidine-l- carboxylate. To a solution of 1-tert-butyl 3-methyl azetidine-l,3-dicarboxylate (900 mg, 4.18 mmol) in THF (25 mL) at 0C was added 3 M methylmagnesium iodide in ether (4.18 mL, 12.54 mmol) dropwise. The reaction was stirred overnight at RT. The reaction was quenched with saturated aqueous ammonium chloride and extracted with EtOAc. The organic layer was concentrated, adsorbed onto a plug of silica gel, and purified by column chromatography, eluting with 20-100% (90:9: 1 DCM/MeOH/NH4OH) / DCM, to provide tert-butyl 3-(2-hydroxypropan-2-yl)azetidine-l-carboxylate as a yellow oil (867 mg, 96 % yield).
  • 2
  • [ 610791-05-4 ]
  • [ 75-16-1 ]
  • [ 1257293-79-0 ]
YieldReaction ConditionsOperation in experiment
95% In tetrahydrofuran; diethyl ether; at 0 - 20℃; for 16h; To a solution of <strong>[610791-05-4]1-(tert-butyl) 3-methyl azetidine-1,3-dicarboxylate</strong> (3.00 g, 13.9 mmol) in anhydrous tetrahydrofuran (30 mL) at 0 C. was added a 3 M solution of methylmagnesium bromide in diethyl ether (11.1 mL, 33.4 mmol). The reaction mixture was allowed to warm to ambient temperature and stirred for 16 h. The reaction mixture and was then diluted with saturated ammonium chloride (20 mL) and extracted with ethyl acetate (2×30 mL). The combined organic layers were washed with brine (20 mL), dried over anhydrous sodium sulfate, and filtered. Concentration of the filtrate in vacuo provided the title compound as a yellow foam (2.85 g, 95% yield): 1H NMR (300 MHz, CDCl3) delta3.89 (dt, J=14.4, 7.3 Hz, 4H), 2.57 (dd, J=10.4, 4.3 Hz, 1H), 1.44-1.43 (m, 9H), 1.19 (s, 6H), OH not observed.
 

Historical Records

Technical Information

Categories

Related Functional Groups of
[ 1257293-79-0 ]

Alcohols

Chemical Structure| 1138331-90-4

A786016 [1138331-90-4]

tert-Butyl 3-(1-hydroxyethyl)azetidine-1-carboxylate

Similarity: 1.00

Chemical Structure| 1638761-21-3

A387485 [1638761-21-3]

tert-Butyl 3-ethyl-3-(hydroxymethyl)azetidine-1-carboxylate

Similarity: 0.96

Chemical Structure| 1330764-31-2

A174664 [1330764-31-2]

tert-Butyl 5-hydroxy-2-azaspiro[3.3]heptane-2-carboxylate

Similarity: 0.94

Chemical Structure| 181269-70-5

A111344 [181269-70-5]

tert-Butyl 4-hydroxy-3-methylpiperidine-1-carboxylate

Similarity: 0.92

Chemical Structure| 955028-90-7

A298578 [955028-90-7]

(3R,4R)-rel-tert-Butyl 4-hydroxy-3-methylpiperidine-1-carboxylate

Similarity: 0.92

Amides

Chemical Structure| 1138331-90-4

A786016 [1138331-90-4]

tert-Butyl 3-(1-hydroxyethyl)azetidine-1-carboxylate

Similarity: 1.00

Chemical Structure| 1935127-58-4

A555968 [1935127-58-4]

tert-Butyl 3-(1-methoxyethyl)azetidine-1-carboxylate

Similarity: 0.98

Chemical Structure| 1638761-21-3

A387485 [1638761-21-3]

tert-Butyl 3-ethyl-3-(hydroxymethyl)azetidine-1-carboxylate

Similarity: 0.96

Chemical Structure| 1330764-31-2

A174664 [1330764-31-2]

tert-Butyl 5-hydroxy-2-azaspiro[3.3]heptane-2-carboxylate

Similarity: 0.94

Chemical Structure| 898271-20-0

A503471 [898271-20-0]

1-Boc-(3-Aminoethyl)azetidine

Similarity: 0.94

Related Parent Nucleus of
[ 1257293-79-0 ]

Azetidines

Chemical Structure| 1138331-90-4

A786016 [1138331-90-4]

tert-Butyl 3-(1-hydroxyethyl)azetidine-1-carboxylate

Similarity: 1.00

Chemical Structure| 1935127-58-4

A555968 [1935127-58-4]

tert-Butyl 3-(1-methoxyethyl)azetidine-1-carboxylate

Similarity: 0.98

Chemical Structure| 1638761-21-3

A387485 [1638761-21-3]

tert-Butyl 3-ethyl-3-(hydroxymethyl)azetidine-1-carboxylate

Similarity: 0.96

Chemical Structure| 1330764-31-2

A174664 [1330764-31-2]

tert-Butyl 5-hydroxy-2-azaspiro[3.3]heptane-2-carboxylate

Similarity: 0.94

Chemical Structure| 898271-20-0

A503471 [898271-20-0]

1-Boc-(3-Aminoethyl)azetidine

Similarity: 0.94