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Chemical Structure| 1258282-48-2 Chemical Structure| 1258282-48-2

Structure of 1258282-48-2

Chemical Structure| 1258282-48-2

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Product Details of [ 1258282-48-2 ]

CAS No. :1258282-48-2
Formula : C15H11ClN2
M.W : 254.72
SMILES Code : NC1=CC=C(C(C2=NC=CC3=C2C=CC=C3)=C1)Cl
MDL No. :MFCD20486516

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Application In Synthesis of [ 1258282-48-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1258282-48-2 ]

[ 1258282-48-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 97-08-5 ]
  • [ 1258282-48-2 ]
  • [ 1258282-42-6 ]
YieldReaction ConditionsOperation in experiment
74% Example 7A solution of 4-chloro-3-nitrobenzene-1-sulfonyl chloride (50 mg, 0.196 mmol) in DCM (4.0 ml_) was added dropwise to a solution of 4-chloro-3-(isoquinolin-1- yl)aniline (50 mg, 0.196 mmol) in DCM (9.8 ml_) at 00C. The reaction mixture was stirred at 0C for 1 h. The reaction was quenched with saturated NaHCO3 solution and the mixture was extracted with EtOAc. The combined extracts were washed with brine, dried over anhydrous Na2SO4 and then concentrated under reduced pressure. The residue was treated with DCM to yield the desired compound (69 mg, 74% yield) as a light yellow solid. 1H NMR (400 MHz, DMSO-d6): delta 11.08 (s, 1 H)1 8.64 (d, J = 6.0 Hz, 1 H), 8.44 (t, J = 1.2 Hz, 1 H), 8.17 (m, 2H), 8.02 (d, J = 1.2 Hz, 2H), 7.95 (m, 1 H), 7.69 (m, 1 H), 7.65 (d, J = 8.8 Hz, 1 H), 7.41 (m, 2H), 7.27 (d, J = 2.8 Hz, 1 H). MS (ESI): Calcd. for C21H14CI2N3O4S: 474, found 474 (M+H)+.
 

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