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Chemical Structure| 1260169-03-6 Chemical Structure| 1260169-03-6

Structure of 1260169-03-6

Chemical Structure| 1260169-03-6

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Product Details of [ 1260169-03-6 ]

CAS No. :1260169-03-6
Formula : C19H26N4O6
M.W : 406.43
SMILES Code : O=C(C1=C2N=CC=CN2N=C1N(C(OC(C)(C)C)=O)C(OC(C)(C)C)=O)OCC
MDL No. :MFCD26940343

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Application In Synthesis of [ 1260169-03-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1260169-03-6 ]

[ 1260169-03-6 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 24424-99-5 ]
  • [ 1260169-02-5 ]
  • [ 1260169-03-6 ]
YieldReaction ConditionsOperation in experiment
31% With N-ethyl-N,N-diisopropylamine;dmap; In acetonitrile; at 20℃; for 3.0h; ethyl 2-(bis(tert-butoxycarbonyl)amino)pyrazolo[l,5-a]pyrimidine-3-carboxylate Di-tert-butyldicarbonate (1.3Og, 5.9 mmol) was added to a solution of ethyl 2-aminopyrazolo[l,5- a]pyrimidine-3-carboxylate (810 mg, 3.9 mmol), 4-dimethylaminopyridine (96 mg, 0.78 mmol), and LambdazetaLambda^-diisopropylethylamine (1.4 niL, 7.8 mmol) in acetonitrile (100 mL). The reaction was stirred at room temperature for 3 hours, then concentrated in vacuo. The residue was partitioned between EtOAc and water, then the layers were separated and the organic layer was washed with brine, then dried over Na2SO/), filtered and concentrated. The residue was purified by silica chromatography, eluting with a 97:3 mixture of DCM: 2M methanolic ammonia solution to afford 370 mg (31%) of ethyl 2-(bis(tert-butoxycarbonyl)amino)pyrazolo[l,5-a]pyrimidine-3- carboxylate. 1H NMR (500 MHz, CDCl3) delta 8.79 (dd, J= 4.2, 1.8, IH), 8.69 (dd, J= 7.0, 1.8, IH), 7.05 (dd, J= 7.0, 4.2, IH), 4.40 (q, J= 7.1, 2H), 1.43 (s, 18H), 1.38 (t, J= 7.1, 3H).
 

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