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Chemical Structure| 1260654-33-8 Chemical Structure| 1260654-33-8

Structure of 1260654-33-8

Chemical Structure| 1260654-33-8

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Product Details of [ 1260654-33-8 ]

CAS No. :1260654-33-8
Formula : C6H3Cl2N3
M.W : 188.01
SMILES Code : N#CC1=C(Cl)C=NC(N)=C1Cl
MDL No. :MFCD11847366

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* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1260654-33-8 ]

[ 1260654-33-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 42182-27-4 ]
  • [ 1260654-33-8 ]
YieldReaction ConditionsOperation in experiment
With N-chloro-succinimide; In N,N-dimethyl-formamide; at 55℃; for 3h; Example 132; 4-(4-MethoxyphenyJ)-N7-(2-methylphenyl)-1H-pyrazolo[3,4-c]pyridine-3,7-diamine Step 1:[00226] A solution of <strong>[42182-27-4]2-aminoisonicotinonitrile</strong> (10.98 g, 92 mmol) and N- chlorosuccinimide (25.8 g, 194 mmol) in N:N-dimethylformamide (100 mL) was heated to 55 °C for 3 h. The mixture was concentrated. The residue was stirred vigorously in water (800 mL) and ethyl acetate (600 mL) for 2 h and filtered to remove the insoluble material. The two phases of the filtrate were separated. The aqueous phase was extracted with 1:1 mixture of ethyl acetate-hexanes (2x200 mL). The combined organic extracts were washed with water (2x100 mL), brine (100 mL), dried (MgSO4) and concentrated to give crude 2-amno-3,5-dichIoroisonicotinonitrileas (19 g) with approximately 85percent purity. The crude material was used in the next reaction without purification.
 

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