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Chemical Structure| 1260751-65-2 Chemical Structure| 1260751-65-2

Structure of 1260751-65-2

Chemical Structure| 1260751-65-2

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Product Details of [ 1260751-65-2 ]

CAS No. :1260751-65-2
Formula : C10H8FNO2
M.W : 193.17
SMILES Code : O=C(OCC)C1=CC(F)=CC=C1C#N
MDL No. :MFCD11041402
InChI Key :QMZSRWKQXUGYBE-UHFFFAOYSA-N
Pubchem ID :55265172

Safety of [ 1260751-65-2 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302
Precautionary Statements:P280-P305+P351+P338

Application In Synthesis of [ 1260751-65-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1260751-65-2 ]

[ 1260751-65-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 139911-28-7 ]
  • [ 557-21-1 ]
  • [ 1260751-65-2 ]
YieldReaction ConditionsOperation in experiment
93% With triphenylphosphine;tris-(dibenzylideneacetone)dipalladium(0); In N,N-dimethyl-formamide; at 130.0℃; for 4.0h;Inert atmosphere; Zinc cyanide (26.5 g; 0.225 mol) and Pd2(dba)3 (1.9 g; 3.4 mmol) were added to a solution of <strong>[139911-28-7]ethyl 2-bromo-5-fluorobenzoate</strong> (27.9 g; 0.112 mol) in DMF (71 ml). Triphenyl phosphine (2.9 g; 11 mmol) was added and then the reaction mixture was stirred at 130C under nitrogen atmosphere for 4 hours. The mixture was poured out into H2O (300 ml) and then extracted with EtOAc (200 ml). The organic layer was separated, washed with H2O (2 x 100 ml), brine (100 ml), dried (MgSO4), filtered and the solvent was evaporated. The residue was purified by column chromatography over silica gel (eluent: hexanes/EtOAc (5/1, v/v)). The product fractions were collected and the solvent was evaporated. Yield: 20 g (93%; orange solid).
 

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