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Chemical Structure| 1262396-34-8 Chemical Structure| 1262396-34-8

Structure of 1262396-34-8

Chemical Structure| 1262396-34-8

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Product Details of [ 1262396-34-8 ]

CAS No. :1262396-34-8
Formula : C13H23NO3
M.W : 241.33
SMILES Code : O=C(N(CC1)[C@H](CO)CC21CC2)OC(C)(C)C
MDL No. :MFCD27955896

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* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1262396-34-8 ]

[ 1262396-34-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1262396-32-6 ]
  • [ 1262396-34-8 ]
YieldReaction ConditionsOperation in experiment
86% With borane-THF; In tetrahydrofuran; at 0 - 20℃;Inert atmosphere;Conversion of starting material; Example 17: Preparation of intermediate 18: (S)-5-hvdroxymethyl-6-aza- spiro[2.51octane-6- carboxylic acid tert-butyl esterTo a solution of (S)-6-aza-spiro[2.5]octane-5,6-dicarboxylic acid 6-tert-butyl ester (intermediate 17, 35g, 0.122mol ) in anhydrous THF (300ml) was added BH3/THF (1 M, 360ml, 0.365mol) under nitrogen at 0 C. After the addition was completed, the reaction mixture was warmed to room temperature and stirred at room temperature for overnight. The resulting mixture was evaporated to obtain a crude that was purified by silica gel chromatography (petroleum ether/ethyl acetate from 10/1 to 5/1 ). (S)-5-Hydroxymethyl-6-aza-spiro[2.5]octane-6-carboxylic acid tert- butyl ester was obtained as colourless oil (31 g), yield:86%.1HNMR (CDCI3) d ppm 4.40 (m, 1 H), 4.01 (m, 1 H), 3.66 (m, 1 H), 3.06 (m, 1 H), 2.03 (m, 1 H), 1.87 (m, 1 H), 1.50 (s, 9H), 1.02 (d, 1 H), 0.85 (d, 1 H), 0.27-0.43 (m, 4H);MS Calcd.: 241 ; MS Found: 142 ([M-100+1 ]+).
 

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