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Chemical Structure| 1264193-15-8 Chemical Structure| 1264193-15-8

Structure of 1264193-15-8

Chemical Structure| 1264193-15-8

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Product Details of [ 1264193-15-8 ]

CAS No. :1264193-15-8
Formula : C9H7BrN2O3
M.W : 271.07
SMILES Code : O=C(C1=NC2=NC=C(Br)C=C2O1)OCC
MDL No. :MFCD27635141

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Application In Synthesis of [ 1264193-15-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1264193-15-8 ]

[ 1264193-15-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 57267-03-5 ]
  • [ 39903-01-0 ]
  • [ 1264193-15-8 ]
YieldReaction ConditionsOperation in experiment
With toluene-4-sulfonic acid; In 1,4-dioxane; for 5h;Reflux; Preparation 10.6-Bromo-oxazolo[4,5-b]pyridine-2-carboxylic acid [00132] 2-Amino-5-bromo-3-hydroxypyridine (200 mg, 1.06 mmol) is dissolved in 3 mL of dioxane, triethoxyacetic acid ethyl ester (0.5 mL) and a catalytic amount of p- toluenesulfonic acid are added. The mixture is heated to reflux for 5 h, then cooled, diluted with DCM and washed with saturated sodium bicarbonate solution. The organic phase is dried over anhydrous sodium sulfate and evaporated to dryness. The residue is purified by flash column chromatography to afford 6-bromo-oxazolo[4,5-b]pyridine-2- carboxylic acid ethyl ester which is dissolved in a mixture of THF (2 mL) and water (0.5 mL). Lithium hydroxide (25 mg, 1 mmol) is added and the mixture is stirred at r.t. for 15 min., then neutralized with diluted hydrochloric acid until pH 7 is reached. The mixture is extracted with EtOAc, the organic phase is dried over anhydrous sodium sulfate and evaporated to dryness to afford sufficiently pure title compound.
 

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