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Chemical Structure| 127425-72-3 Chemical Structure| 127425-72-3

Structure of 127425-72-3

Chemical Structure| 127425-72-3

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Product Details of [ 127425-72-3 ]

CAS No. :127425-72-3
Formula : C9H6Br2O
M.W : 289.95
SMILES Code : O=C1C(Br)CC2=C1C=CC(Br)=C2

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Application In Synthesis of [ 127425-72-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 127425-72-3 ]

[ 127425-72-3 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 33543-78-1 ]
  • [ 127425-72-3 ]
  • [ 156484-65-0 ]
YieldReaction ConditionsOperation in experiment
With sodium iodide; In ethanol; dichloromethane; a solution of 9.5 g of <strong>[33543-78-1]ethyl imidazole-2-carboxylate</strong>, 9.9 g of 2,5-dibromo-1-indanone and 0.1 g of sodium iodide in 280 ml of ethanol is kept boiling for 16 hours, cooled to 20° C. and dried under reduced pressure (20 mmHg; 2.6 kPa) at 50° C. The product obtained (21 g) is dissolved in 50 ml of dichloromethane and the solution is washed 3 times with a total of 600 ml of distilled water, dried over anhydrous magnesium sulphate and dried under reduced pressure (20 mmHg; 2.6 kPa) at 50° C. The product obtained (12.7 g) is chromatographed on 790 g of neutral silica gel (0.020-0.045 mm) contained in a column 7 cm in diameter, eluding under pressure with a dichloromethane-ethyl acetate mixture (70-30 by volume) and collecting 75-ml fractions. Fractions 70 to 140 are pooled and concentrated to dryness under reduced pressure (15 mmHg; 2 kPa) at 40° C. 3.7 g of ethyl 1-(5-bromo-1-oxo-2-indanyl)imidazole-2-carboxylate are thus obtained which melt at 140° C. The 2,5-dibromo-1-indanone can be prepared as described in European Patent 346107.
 

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