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Chemical Structure| 127555-22-0 Chemical Structure| 127555-22-0

Structure of 127555-22-0

Chemical Structure| 127555-22-0

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Product Details of [ 127555-22-0 ]

CAS No. :127555-22-0
Formula : C10H12N2O
M.W : 176.22
SMILES Code : O=C1C(C)(C)C2=CC=CN=C2N1C
MDL No. :MFCD00889379

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Application In Synthesis of [ 127555-22-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 127555-22-0 ]

[ 127555-22-0 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 5654-97-7 ]
  • [ 74-88-4 ]
  • [ 127555-22-0 ]
YieldReaction ConditionsOperation in experiment
With NaH; In tetrahydrofuran; (2S)-N-methyl-1-phenylpropan-2-amine hydrate; EXAMPLE 5 1,3-Dihydro-1,3,3-trimethyl-2H-pyrrolo [2,3-b]pyridin-2-one (Compound Y) STR82 Add sodium hydride (20.5 g of 60% NaH in oil, 0.51 mole, washed with hexane) portionwise to 1,3-dihydro-2H-pyrrolo[2,3-b]-pyridin-2-one (19.3 g, 0.14 mole) in dry THF (800 mL) under a N2 atmosphere. Stir for 5 minutes at room temperature, and then add iodomethane (30.8 mL, 70.3 g, 0.495 mole). Stir for 16 hours at room temperature. Pour the reaction mixture into ice water (500 mL), and extract with diethyl ether. Dry the organic solution with MgSO4, filter, and rotoevaporate to give an oil. Triturate the oil with hot petroleum ether, filter, and rotoevaporate the filtrate to give a brown soft solid. Purify the crude product by vacuum short path distillation to give a solid (b.p. 73-76 C. at 0.3 mmHg). Recrystallize with petroleum ether to give the title compound (Y) as a white solid (3.3 g, m.p. 59-60 C.).
 

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