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[ CAS No. 128244-01-9 ] {[proInfo.proName]}

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Product Details of [ 128244-01-9 ]

CAS No. :128244-01-9 MDL No. :MFCD09056754
Formula : C14H20N2 Boiling Point : -
Linear Structure Formula :- InChI Key :YIZAKHJUGTXWTG-UHFFFAOYSA-N
M.W :216.32 Pubchem ID :15634713
Synonyms :

Safety of [ 128244-01-9 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H315-H319-H335 Packing Group:N/A
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Application In Synthesis of [ 128244-01-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 128244-01-9 ]
  • Downstream synthetic route of [ 128244-01-9 ]

[ 128244-01-9 ] Synthesis Path-Upstream   1~1

  • 1
  • [ 24424-99-5 ]
  • [ 128244-01-9 ]
  • [ 646055-62-1 ]
YieldReaction ConditionsOperation in experiment
97.4% With triethylamine In dichloromethane at 20℃; Stirring overnight Di-t-butyl dicarbonate (1.45 g, 6.64 mmol) was added to a solution of 1-benzyl-1,7-diazaspiro[4.4]nonane (1.30 g, 6.01 mmol) and triethylamine (1 mL) in dichloromethane (25 mL), and the mixture was stirred at ambient temperature overnight. The mixture was poured into saturated aqueous sodium bicarbonate (10 mL) and extracted with chloroform (4 x 25 mL). The extracts were dried (K2CO3) and concentrated by rotary evaporation. The residue was column chromatographed on Merck silica gel 60 (70-230 mesh), eluting with, to give 1.85 g (97.4 percent) of viscous, colorless oil, after concentration of selected fractions.
97.4% With triethylamine In dichloromethane at 20℃; Di-t-butyl dicarbonate (1.45 g, 6.64 mmol) was added to a solution of 1-benzyl-l,7-diazaspiro[4.4]nonane (1.30 g, 6.01 mmol) and triethylamine (1 mL) in dichloromethane (25 mL), and the mixture was stirred at ambient temperature overnight. The mixture was poured into saturated aqueous sodium bicarbonate (10mL) and extracted with chloroform (4 x 25 mL). The extracts were dried (K2CO3) and concentrated by rotary evaporation. The residue was column chromatographed on Merck silica gel 60 (70-230 mesh), eluting with, to give 1.85 g (97.4percent) of viscous, colorless oil, after concentration of selected fractions
Reference: [1] Patent: WO2004/5293, 2004, A2, . Location in patent: Page 60
[2] Patent: WO2006/23630, 2006, A2, . Location in patent: Page/Page column 57-58
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